기본 정보
- CAS
494-79-1- 표준 SMILES
Nc1nc(N)nc(Nc2ccc([As]3SCC(CO)S3)cc2)n1- InChIKey
JCYZMTMYPZHVBF-UHFFFAOYSA-N- 분자식
- C12H15AsN6OS2
- 평균 분자량
- 398.3 g/mol
- 단동위원소 질량
- 397.996471
개요
Melarsoprol is a member of triazines.
이름 및 식별자
- 우선 이름
- Melarsoprol
- IUPAC
- [2-[4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl]-1,3,2-dithiarsolan-4-yl]methanol
- 현지명
- 멜라소폴
- 영어명
- melarsoprol
- 분자식
- C12H15AsN6OS2
- 분자량
- 398.345
이름 및 동의어
MELARSOPROL494-79-1Mel BMelarsoprolumRP 3854[2-[4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl]-1,3,2-dithiarsolan-4-yl]methanolRP-3854DTXSID90862033ZF3786Q2E81,3,2-Dithiarsolane-4-methanol, 2-(4-((4,6-diamino-1,3,5-triazin-2-yl)amino)phenyl)-(2-(4-((4,6-diamino-1,3,5-triazin-2-yl)amino)phenyl)-1,3,2-dithiarsolan-4-yl)methanolMelarsenoxidBAL
이름 더 보기
멜라소폴RP3854Melarsoprol (Mixture of DiastereoMers)2-[4-(4,6-Diamino-1,3,5-triazine-2-ylamino)phenyl]-1,3,2-dithiarsolane-4-methanol[2-[4-[(4,6-diamino-s-triazin-2-yl)amino]phenyl]-1,3,2-dithiarsolan-4-yl]methanol2-[4-[(4,6-Diamino-1,3,5-triazin-2-yl)amino]phenyl]-1,3,2-dithiarsolane-4-methanol1,3,2-Dithiarsolane-4-methanol, 2-[4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl]-
Melarsenoxid BAL(2-{4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl}-1,3,2-dithiarsolan-4-yl)methanolRefChem:156313DTXCID00810863P01CD01207-793-4ArsobalMelarsoprolum [INN-Latin]
물성
구조 계산 물성
- 극성 표면적
- 174 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 9
- 회전 가능 결합 수
- 4
- 무거운 원자 수
- 22
- 형식 전하
- 0
- 복잡도
- 353
실험 및 물리화학적 성질
Human DrugsMedicines for the treatment of 2nd stage African trypanosomiasis
물리화학적 성질
- 저장 조건
- 2 · 2-8°C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨, 가열)
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
- InChI
- 1S/C12H15AsN6OS2/c14-10-17-11(15)19-12(18-10)16-8-3-1-7(2-4-8)13-21-6-9(5-20)22-13/h1-4,9,20H,5-6H2,(H5,14,15,16,17,18,19)
- InChIKey
- JCYZMTMYPZHVBF-UHFFFAOYSA-N
- SMILES
- NC1=NC(N)=NC(NC2=CC=C(C=C2)[As]3SCC(S3)CO)=N1
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H301+H331 (33.3%): Toxic if swallowed or if inhaled [Danger Acute toxicity, oral; acute toxicity, inhalation]
P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 3 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory InformationRestricted substance: Melarsoprol
Hazard Classes and CategoriesAcute Tox. 3 (100%)
안전 데이터
- wgk
- WGK 3
- Hazard Classifications
- Acute Tox. 3 InhalationAcute Tox. 3 OralAquatic Acute 1Aquatic Chronic 1
- 스토리지 클래스
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
화학 및 산업
약리 정보
ATC Code
P - Antiparasitic products, insecticides and repellents
QP - Antiparasitic products, insecticides and repellents
P01CD01
MeSH Pharmacological ClassificationAgents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.
응용 분야
개요Knowingly or unknowingly, arsenic-containing drugs have been used for treatment of parasitic conditions for thousands of years. In the late 1800s and early 1900s, Paul Ehrlich introduced the use of trivalent arsenicals. Melarsoprol, an organoarsenical, came into use in the late 1940s, and it remains the first-choice drug in the treatment of trypanosomiasis. Until 1990, it also was the only treatment for late-stage sleeping sickness.
용도Melarsoprol is a drug used for the treatment of African trypanosomes, a sleeping sickness in humans, a disease that is typically fatal without chemotherapy.
공급사18 곳
湖北瑞玛标物科技有限公司15787879035 15787875101 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
怀化市冰峰化工有限公司0745-2866851 17711757908 · [email protected]
湖北广奥生物科技有限公司027-02702759223056 18162699093 · [email protected]
上海陶素生化科技有限公司021-33632979 · [email protected]
陕西缔都医药化工有限公司029-81024372 17792795018 · [email protected]
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