S-니트로소글루타티온

S-Nitrosoglutathione

HCID 104858CAS 57564-91-7

기본 정보

표준 SMILES
N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(=O)O)C(=O)O
InChIKey
HYHSBSXUHZOYLX-WDSKDSINSA-N
분자식
C10H16N4O7S
평균 분자량
336.32 g/mol
단동위원소 질량
336.07396985

개요

S-nitrosoglutathione is a glutathione derivative that is glutathione in which the hydrogen attached to the sulfur has been replaced by a nitroso group. It has a role as a bronchodilator agent, a platelet aggregation inhibitor, a nitric oxide donor and a signalling molecule. It is a nitrosothio compound and a glutathione derivative. It is a conjugate acid of a S-nitrosoglutathione(2-).

이름 및 식별자

우선 이름
S-Nitrosoglutathione
IUPAC
(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-nitrososulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
현지명
S-니트로소글루타티온
영어명
S-NITROSOGLUTATHIONE
분자식
C10H16N4O7S
분자량
336.32

이름 및 동의어

57564-91-7gsnoS-nitrosoglutathioneNitrosoglutathioneSNOGGlutathione thionitriteN-(N-L-gamma-Glutamyl-S-nitroso-L-cysteinyl)glycine78RRI89ZTODTXSID1040613Glycine, N-(N-L-gamma-glutamyl-S-nitroso-L-cysteinyl)-RVC 588 (PEPTIDE)(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-(nitrososulfanyl)ethyl]carbamoyl}butanoic acid
이름 더 보기
S-니트로소글루타티온GNSORVC 588GSNO, SNOGS-NitrosoglutationeS-Nitrosylglutathione
CHEBI:50091(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-nitrososulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acidS-Nitroso-GSH(2S)-2-amino-4-(((1R)-1-((carboxymethyl)carbamoyl)-2-(nitrososulfanyl)ethyl)carbamoyl)butanoic acid(2S)-2-amino-5-(((2R)-1-(carboxymethylamino)-3-nitrososulfanyl-1-oxopropan-2-yl)amino)-5-oxopentanoic acidRefChem:180705DTXCID401526730637-341-5

데이터베이스 식별자

CAS
57564-91-7
PubChem CID
104858
DTXSID
DTXSID1040613
ChEMBL
CHEMBL63507
ChEBI
CHEBI:50091
UNII
78RRI89ZTO
EC Number
637-341-5
Nikkaji
J361.904D

물성

구조 계산 물성

XLogP
-4.8
극성 표면적
214 Ų
수소 결합 공여자 수
5
수소 결합 수용자 수
10
회전 가능 결합 수
10
무거운 원자 수
22

실험 및 물리화학적 성질

Physical DescriptionSolid

물리화학적 성질

녹는점
170 °C · >170°C (dec.)
밀도
1.68 · 1.68
굴절률
1.6 · 1.6000 (estimate)
저장 조건
-20 °C · -20°C
용해도
DMSO(약간 용해됨), 물(약간 용해됨)
물리적 상태
분홍색 고체

화학적 성질

Pink Powder

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

안전 데이터

wgk
3
rtecs
MC0558000
risk_code
36/37/38
hazard_code
Xi
safety_code
26-36
스토리지 클래스
11 - Combustible Solids

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 6건

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

Agents that cause an increase in the expansion of a bronchus or bronchial tubes.

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.

Drugs used to cause dilation of the blood vessels.

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.

A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)

응용 분야 · 3건

개요S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.

용도S-Nitrosoglutathione (GSNO) has been used:as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.

일반 설명A utility carrier of nitric oxide. Breaks down at physiological pH to produce nitric oxide. Causes smooth muscle relaxation and inhibits platelet aggregation. Induces apoptosis in mouse thymocytes. Note: 1 set = 5 x 2.5 mg.

공급사50 곳

湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
上海康朗生物科技有限公司021-61998208 18217752821 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]

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