기본 정보
- CAS
130495-35-1- 표준 SMILES
COc1ccc(CCCOC(Cn2ccnc2)c2ccc(OC)cc2)cc1.Cl- InChIKey
FWLPKVQUECFKSW-UHFFFAOYSA-N- 분자식
- C22H27ClN2O3
- 평균 분자량
- 402.9 g/mol
- 단동위원소 질량
- 402.1710204
개요
SKF-96365 hydrochloride is the hydrochloride salt of SKF-96365. It is a TRP channel blocker. It has a role as an autophagy inducer, a TRP channel blocker, an antineoplastic agent, a calcium channel blocker, a platelet aggregation inhibitor, a GABA antagonist and an apoptosis inducer. It contains a SKF-96365 free base(1+).
이름 및 식별자
- 우선 이름
- Skf 96365
- IUPAC
- 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole;hydrochloride
- 현지명
- SKF96365염산염
- 영어명
- SKF 96365 hydrochloride
- 분자식
- C22H27ClN2O3
- 분자량
- 402.91
이름 및 동의어
130495-35-1SKF-96365SKF96365SK&F 963651-(2-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole hydrochloride33BI32858PSK&F-963651H-Imidazole, 1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-, monohydrochlorideRefChem:9318391-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole1-(2-(4-Methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)imidazoleSkf 96365
이름 더 보기
SKF96365염산염CS-2170SKF 96365 HCISKF-96365, HCSKF-96365, HClSK AND F 96365SKF 96365 hydrochlorSKF 96365, TRP channel blocker
SKF 96365 HYDROCHLORIDESKF-96365 hydrochloride1-(2-(4-Methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-1H-imidazole hydrochlorideSKF-96365 (hydrochloride)MFCD002364071-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole;hydrochloride1H-Imidazole, 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-, hydrochloride (1:1)1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole hydrochloride
물성
구조 계산 물성
- 극성 표면적
- 45.5 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 10
- 무거운 원자 수
- 28
- 형식 전하
- 0
- 복잡도
- 393
물리화학적 성질
- 녹는점
- 119 °C · 119 °C
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 2 O: · H2O: >20 mg/mL
- 물리적 상태
- 고체
- 색상
- 하얀색
- 수용성
- 100 mM까지 · 물에 100mM까지 용해됨
- 안정성
- 1 · 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 증류수에 용해된 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- InChI
- 1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H
- InChIKey
- FWLPKVQUECFKSW-UHFFFAOYSA-N
- SMILES
- Cl.COc1ccc(CCCOC(Cn2ccnc2)c3ccc(OC)cc3)cc1
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
안전 데이터
- wgk
- 3
- HS 번호
- 2933.29.4300
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
응용 분야
용도SKF 96365 Hydrochloride is a novel inhibitor of receptor-mediated calcium entry.
일반 설명Inhibits receptor-mediated Ca2+ entry in stimulated platelets (IC50 = 8-12 μM in intact platelets), neutrophils, and endothelial cells (IC50 = 30 μM for human endothelial cells) at concentrations that do not affect internal Ca2+ release. Also inhibits voltage-gated Ca2+ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.
공급사81 곳
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
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