기본 정보
- CAS
83104-85-2- 표준 SMILES
COc1cc(N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)c2nc(COc3cc(C)ccc3N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)ccc2c1- InChIKey
ANRZUBSJAOAXHS-UHFFFAOYSA-N- 분자식
- C38H43N3O18
- 평균 분자량
- 829.8 g/mol
- 단동위원소 질량
- 829.25416153
개요
structure given in first source
이름 및 식별자
- 우선 이름
- Quin2-acetoxymethyl ester
- IUPAC
- acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[[8-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-6-methoxyquinolin-2-yl]methoxy]-4-methylanilino]acetate
- 현지명
- 퀸오전2시
- 영어명
- QUIN 2-AM
- 분자식
- C38H43N3O18
- 분자량
- 829.76
이름 및 동의어
83104-85-2Quin-2 acetoxymethyl esterQuin2-acetoxymethyl esterQuin 2amQuin2-AM8EF0C5H59DDTXSID10232173Glycine, N-(2-((acetyloxy)methoxy)-2-oxoethyl)-N-(2-((8-(bis(2-((acetyloxy)methoxy)-2-oxoethyl)amino)-6-methoxy-2-quinolinyl)methoxy)-4-methylphenyl)-, (acetyloxy)methyl esterRefChem:871867DTXCID10154664Quin-2AMQUIN 2-AM
이름 더 보기
퀸오전2시Quin 2 Am EsterAcetoxymethyl esterquin2-acetoxymethylesterQuin-2, AM *CAS 83104-85-2*QUIN-2 TETRAACETOXYMETHYL ESTER8-Amino-2-[(2-amino-5-methylphenoxy)-methyl]-6-methoxyquinoline-N,N,N',N'-tetraacetic acidTetrakis(acetoxymethyl) 8-amino-2-[(2-amino-5-methylphenoxy)methyl]-6-methoxyquinoline-N,N,N′,N′-tetraacetate2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrakis(acetoxymethyl ester)2-[(2-AMINO-5-METHYLPHENOXY)METHYL]-6-METHOXY-8-AMINO-QUINOLINE-N,N,N',N'-TETRAACETIC ACID TETRAKIS(ACETOXYMETHYL-ESTER)
물성
구조 계산 물성
- XLogP
- 3.9
- 극성 표면적
- 248 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 21
- 회전 가능 결합 수
- 30
- 무거운 원자 수
- 59
- 형식 전하
- 0
- 복잡도
- 1,380
물리화학적 성질
- 밀도
- 1.36 · 1.360
- 인화점
- 113 °C · 113 °C
- 저장 조건
- 20 °C · −20°C
- 용해도
- DMSO: 용해될 수 있다
- 물리적 상태
- 고체
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
안전 데이터
- wgk
- 3
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- F 고인화성물질
- 1-8-10
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.
Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
응용 분야
개요Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 . As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM. It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH. High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells. Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.
용도Quin 2-AM is a cell permeable fluorescent probe for Ca2+ that gives a large shift in the UV absorption spectrum and a 20-fold increase in fluorescence upon Ca2+ binding.
공급사13 곳
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
天津希恩思生化科技有限公司400 638 7771 · [email protected]
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