노나-2-6-디엔니트릴

This chemical does not meet GHS hazard criteria for 100% (91 of 91) of all reports.

Not Classified

Aggregated GHS information provided per 91 reports by companies from 1 notifications to the ECHA C&L Inventory.

The existing information was reviewed by the independent Expert Panel for Fragrance Safety and supports the use of 2,6-Nonadienenitrile as described in this safety assessment. Data show that 2,6-nonadienenitrile is not genotoxic. Data on read-across analog E- and Z-2(+3),12-tridecadiennitrile (CAS # 124071-40-5) provided 2,6-nonadienenitrile a calculated Margin of Exposure (MOE) greater than 100 for the repeated dose toxicity endpoint. The reproductive and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure is below the TTC (0.0015 mg/kg/day and 0.47 mg/day, respectively). Data show that there are no safety concerns for skin sensitization under the current declared levels of use. 2,6-nonadienenitrile is not expected to be phototoxic/photoallergenic based on an evaluation of the ultraviolet/visible (UV/Vis) spectra.

The existing information was reviewed by the independent Expert Panel for Fragrance Safety and supports the use of 2,6-nonadienenitrile as described in this safety assessment. It was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are less than 1.