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에코티오페이트요오드화물

Echothiophate Iodide

HCID 10547
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
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기본 정보

CAS
513-10-0
표준 SMILES
CCOP(=O)(OCC)SCC[N+](C)(C)C.[I-]
InChIKey
OVXQHPWHMXOFRD-UHFFFAOYSA-M
분자식
C9H23INO3PS
평균 분자량
383.23 g/mol
단동위원소 질량
383.0181

개요

Ecothiopate iodide is the iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, an antiglaucoma drug and a miotic. It is an iodide salt and a quaternary ammonium salt. It contains an ecothiopate.

이름 및 식별자

우선 이름
Echothiophate Iodide
IUPAC
2-diethoxyphosphorylsulfanylethyl(trimethyl)azanium iodide
현지명
에코티오페이트요오드화물
영어명
Ecothiopate iodide
분자식
C9H23INO3PS
분자량
383.227051

이름 및 동의어

Echothiophate iodideECOTHIOPATE IODIDE513-10-0EchodideEcothiophate iodideEcothiopati iodidumPhospholine iodideIodure d'ecothiopateIoduro de ecotiopato217-miDiethoxyphosphoryl-thiocholine iodideEchothiophate iodide (USP)
이름 더 보기
에코티오페이트요오드화물ECHOTHIOPHATEEcothiopate217MIEcostigmineECOTHIOPHATEPHOSPHOLINEIODIDEEchothiopate iodide
2-Diethoxy-phosphinylthioethyl-trimethylammonium iodideBA9QH3P00TEthanaminium, 2-((diethoxyphosphinyl)thio)-N,N,N-trimethyl-, iodideN-(2-(Diethoxyphosphinylthio)ethyl)trimethylammonium iodideO,O-Diethyl S-2-trimethylammonium ethylphosphonothiolate iodideDTXSID1022976S-(2-(N,N,N-Trimethylammonio)ethyl) O,O-diethylphosphorothiolate iodide(2-Mercaptoethyl)trimethylammonium iodide S-ester with O,O-diethyl phosphorothioate

데이터베이스 식별자

CAS
513-10-0
PubChem CID
10547
DTXSID
DTXSID1022976

물성

구조 계산 물성

극성 표면적
60.8 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
5
회전 가능 결합 수
8
무거운 원자 수
16
형식 전하
0
복잡도
208

실험 및 물리화학적 성질

Human Drugs · 3건

Breast Feeding; Lactation; Cholinesterase Inhibitors; Miotics; Parasympathomimetics

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

물리화학적 성질

녹는점
138 ° · 138° (Tammelin); mp 124-124.5° (Fitch)
저장 조건
-20 °C · Store at -20°C
용해도
DMSO: Slightly Soluble; Methanol: Slightly Soluble; Water: Slightly Soluble
물리적 상태
고체
안정성
흡습성
EPA
2 · Ethanaminium, 2-[(diethoxyphosphinyl)thio]-N,N,N-trimethyl-, iodide (513-10-0)

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

독성 정보

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

안전 데이터

ridadr
3249
포장분류
II
위험 등급
6.1(a)

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 3건

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.

Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

응용 분야 · 2건

용도Cholinergic (ophthalmic).

용도Echothiophate is a phosphorylthiocholine with pharmacological action analogous to that of isofluorophate; however, spontaneous reduction of phosphorylated enzyme occurs faster after using isofluorophate. It is used in various forms of glaucoma.

상·하류 제품 정보

상류 원료

요오드 메탄나트륨클로로인산디에틸에스테르

공급사11 곳

관련 반응

0건
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화합물 노트

불러오는 중…

이 페이지에서기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
ChEMBL
CHEMBL1200367
ChEBI
CHEBI:59849
UNII
BA9QH3P00T
EC Number
208-152-1
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추가 설명

정의ChEBI: The iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.