스타놀론

Dihydrotestosterone

HCID 10635CAS 521-18-6

기본 정보

표준 SMILES
C[C@]12CCC(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12
InChIKey
NVKAWKQGWWIWPM-ABEVXSGRSA-N
분자식
C19H30O2
평균 분자량
290.4 g/mol
단동위원소 질량
290.2245802

개요

17beta-hydroxy-5alpha-androstan-3-one is a 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5. It has a role as an androgen, a mouse metabolite, a human metabolite and a Daphnia magna metabolite. It is a 3-oxo-5alpha-steroid, a 17beta-hydroxy steroid and a 17beta-hydroxyandrostan-3-one. It derives from a hydride of a 5alpha-androstane.

이름 및 식별자

우선 이름
Dihydrotestosterone
IUPAC
(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
현지명
스타놀론
영어명
Stanolone
분자식
C19H30O2
분자량
290.45

이름 및 동의어

STANOLONEAndrostanolonedihydrotestosterone521-18-6AnabolexAndractimAndroloneNeodrol4-DihydrotestosteroneAnaboleenProteinaStanaprol
이름 더 보기
스타놀론안드로스타놀론안드로스타놀론스타놀론DHT5α-Dihydrotestosterone5α-DHT5α-androstan-17β-ol-3-oneStanolon
Protona5alpha-DihydrotestosteroneCristerona MB17beta-Hydroxy-5alpha-androstan-3-oneAndrostanolona5alpha-Androstan-17beta-ol-3-one5-alpha-DihydrotestosteroneTestosterone, dihydro-

데이터베이스 식별자

CAS
521-18-6
PubChem CID
10635
DTXSID
DTXSID9022364
ChEMBL
CHEMBL27769
ChEBI
CHEBI:16330
UNII
08J2K08A3Y
EC Number
208-307-3
Nikkaji
J39.503J

물성

구조 계산 물성

XLogP
3.7
극성 표면적
37.3 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
2
회전 가능 결합 수
0
무거운 원자 수
21

실험 및 물리화학적 성질

Chemical ClassesHormone
Drugs · 3건

DEA NFLIS-Drug Category -> Steroids

DEA Schedule III Controlled Substance -> Anabolic steroids

Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds

LipidsLipids -> Sterol Lipids [ST] -> Steroids [ST02] -> C19 steroids (androgens) and derivatives [ST0202]
SpringerMaterials PropertiesChemical shift
LogP3.55
Human DrugsPharmaceuticals

물리화학적 성질

녹는점
178 · 178-183 °C
끓는 점
372.52 °C · 372.52°C (rough estimate)
밀도
1.032 · 1.0320 (rough estimate)
굴절률
1.4709 · 1.4709 (estimate)
인화점
9 ℃ · 9℃
저장 조건
2 · 2-8°C

화학적 성질

White Crystalline Solid

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H351 (98.3%): Suspected of causing cancer [Warning Carcinogenicity]

P203, P280, P318, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 60 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 2건

DEA schedule III controlled substance

Status: Cease Manufacture Update: 31-10-2012 https://echa.europa.eu/registration-dossier/-/registered-dossier/12136

Hazard Classes and CategoriesCarc. 2 (98.3%)

독성 정보

Exposure RoutesBioavailability is very low (0-2%) following oral administration.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Drug Induced Liver Injury · 4건

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

ANDROSTANOLONE

DILI Positive

DOI:10.1016/j.drudis.2019.09.022

USGS Health-Based Screening Levels for Evaluating Water-Quality · 3건

Dihydrotestosterone

Hormone

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

안전 데이터

wgk
3
rtecs
BV8052000
ridadr
UN1230 - class 3 - PG 2 - Methanol, solution
risk_code
61-40-39/23/24/25-23/24/25-11
hazard_code
Xn,T,F
safety_code
53-36/37/39-45-36/37-16

화학 및 산업

약리 정보

ATC Code · 4건

A - Alimentary tract and metabolism

G - Genito urinary system and sex hormones

QA - Alimentary tract and metabolism

QG - Genito urinary system and sex hormones

MeSH Pharmacological Classification · 1건

Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.

Absorption, Distribution and ExcretionBioavailability is very low (0-2%) following oral administration.
Tissue LocationsAdipose Tissue
Cellular LocationsCytoplasm
Metabolite PathwaysAndrogen and Estrogen Metabolism

용도 및 제조

UsesDihydrotestosterone is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation.
Use ClassificationPharmaceuticals
응용 분야 · 3건

개요Stanolone is well known as dihydrotestosterone (DHT), which is an endogenous androgen sex steroid and hormone. It is an agonist of the androgen receptor (AR). It plays important physiological role in sexual differentiation, maturation of the penis and scrotum, hair, sebum production and development and maintenance of the prostate gland and seminal vesicles. It is mainly used for the treatment of male hypogonadism, androgen deficiency of severe illness, androgen deficiency of ageing and microphallus in infancy.

용도Stanolone is a potent androgenic metabolite of testosterone that It is Controlled substance. It was created for the treatment of muscle wasting disease, and osteoporosis. It is a powerful anabolic steroid, which is similar to the body's naturally produced Dihydrotestosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid.

일반 설명Dihydrotestosterone (Item No. 15874) is an analytical reference standard categorized as an anabolic androgenic steroid. Anabolic steroids, including dihydrotestosterone, have been used to enhance physical performance in athletes. Dihydrotestosterone is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.

공급사50 곳

Shanghai Biolang Biotechnology Co., Ltd.+86-15970428662 +86-13397199602 · [email protected]
Hong Kong Tiansheng New Material Trading Co., Ltd+8617320695765 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
Hebei shuoxi biotechnology co. LTD+8613081092107
河北展药生物科技有限公司15369953316 +8615369953316 · [email protected]
추가 설명 · 1건

정의ChEBI: Stanolone is a 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5. It has a role as an androgen, a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a 17beta-hydroxy steroid, a 17beta-hydroxyandrostan-3-one and a 3-oxo-5alpha-steroid. It derives from a hydride of a 5alpha-androstane.

관련 반응

11건

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