Flavone (HCID 10680)

개요

Flavone is the simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2. It has a role as a metabolite and a nematicide.

이름 및 식별자

우선 이름: Flavone
IUPAC: 2-phenylchromen-4-one
현지명: 플라본
영어명: FLAVONE
분자식: C15H10O2
분자량: 222.24

이름 및 동의어

FLAVONE525-82-62-Phenyl-4H-chromen-4-one2-Phenylchromone2-Phenyl-4-chromoneAsmacoril2-Phenyl-4H-1-benzopyran-4-oneChromocorCromaril2-phenylchromen-4-onePhenylchromone2-Phenyl-4-benzopyron

이름 더 보기

플라본Wild chrysanthemum extractDA603494166III

Cromarile2-Phenyl-gamma-benzopyroneFlavon2-Phenylbenzopyran-4-one2-Phenyl-4H-benzopyran-4-oneDTXSID2022048NSC-190282-phenyl-1,4-benzopyrone

데이터베이스 식별자

CAS: 525-82-6
PubChem CID: 10680
DTXSID: DTXSID2022048
ChEMBL: CHEMBL275638
ChEBI: CHEBI:42491
UNII: S2V45N7G3B
EC Number: 208-383-8
Nikkaji: J53.111A

물성

구조 계산 물성

XLogP: 3.6
극성 표면적: 26.3 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 2
회전 가능 결합 수: 1
무거운 원자 수: 17
형식 전하: 0
복잡도: 326

실험 및 물리화학적 성질

DrugsPharmaceuticals -> Listed in ZINC15

LipidsPolyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]

SpringerMaterials PropertiesChemical shift

LogP · 2건

3.56

3.49

Melting Point100 °C

Physical DescriptionSolid

물리화학적 성질

녹는점: 94 · 94-97 °C (lit.)
끓는 점: 185 °C · 185 °C / 1mmHg
밀도: 1.1404 · 1.1404 (rough estimate)
굴절률: 1.66 · 1.6600 (estimate)
저장 조건: Sealed in dry,Room Temperature
용해도: 38.3 mg/mL · >38.3 mg/mL in EtOH; >52.3 mg/mL in DMSO
물리적 상태: 결정성 분말
색상: 하얀색
수용성: 아세톤(25 mg/ml), 메탄올, 알코올 및 클로로포름에 용해됩니다. 물에 불용성.
Merck: 14 · 14,4092
BRN: 157598 · 157598
InChI: InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H
InChIKey: VHBFFQKBGNRLFZ-UHFFFAOYSA-N
SMILES: C1(C2=CC=CC=C2)OC2=CC=CC=C2C(=O)C=1
LogP: 3.56 · 3.560
EPA: Flavone (525-82-6)

화학적 성질

white crystalline powder

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

독성 정보

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

안전 데이터

wgk: 2
tsca: TSCA listed
rtecs: DJ3100630
HS 번호: 29329990
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36
위험 참고 사항: Irritant
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

약리 정보

Tissue LocationsFibroblasts

Cellular LocationsMembrane

용도 및 제조

UsesIn studies, quercetin is found to be the most active of the flavonoids, and many medicinal plants owe much of their activity to their high quercetin content.

General Manufacturing Information4H-1-Benzopyran-4-one, 2-phenyl-: INACTIVE

응용 분야

용도Flavone is a potentially useful biochemical for cytochrome P450 studies.

상·하류 제품 정보

상류 원료

Benzenemethanol, 2-hydroxy-α-(2-phenylethynyl)-2-Propyn-1-one, 1-[2-(acetyloxy)phenyl]-3-phenyl-2-Propyn-1-one, 1-(2-hydroxyphenyl)-3-phenyl-3-Methoxyflavone (E)-2'-하이드록시칼콘 에티일벤젠 메틸알콜 carbon monoxide

하류 제품

beta-Phenylpropiophenone α-Naphthoflavone Enzymaticallv modified rutin monopotassium and tripotassium glycyrrhi-mate CACAO PIGMENT 1-(2-히드록시페닐)-3-페닐-1,3-프로판디온 5-Hydroxyflavone 크로몬

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

郑州阿尔法化工有限公司+86-18530059196 · [email protected]

湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]

上海达立康医药科技有限公司18658316824

추가 설명 · 1건

정의One of a group of flavonoid plant pigments existing as colorless needles, that are insoluble in water and melting at 100C. It fluoresces violet in concentrated sulfuric acid. It can be synthesized. Treatment with alcoholic alkali yields flavanone. The fla

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개요