세포탁심 나트륨

Cefotaxime Sodium

HCID 10695961CAS 64485-93-4
부분 구조 검색유사 구조 찾기

기본 정보

표준 SMILES
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(COC(C)=O)CS[C@H]12)c1csc(N)n1.[Na+]
InChIKey
AZZMGZXNTDTSME-JUZDKLSSSA-M
분자식
C16H16N5NaO7S2
평균 분자량
477.5 g/mol
단동위원소 질량
477.03888413

개요

Cefotaxime sodium is a cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups. It contains a cefotaxime(1-).

이름 및 식별자

우선 이름
Cefotaxime Sodium
IUPAC
sodium (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
현지명
세포탁심 나트륨
영어명
Cefotaxime sodium
분자식
C16H18N5NaO7S2
분자량
479.46

이름 및 동의어

CEFOTAXIME SODIUMCEFOTAXIME SODIUM SALT64485-93-4Sodium cefotaximePretor(+)-Cefotaxime sodium saltHR 756DTXSID4046991RU 24756HR-756258J72S7TZHR756
이름 더 보기
세포탁심나트륨세포탁심나트륨(CEFOTAXIMESODIUM)ctxCEFOTAXIME SODIUM STERILECLAFORANCEFOTAXIME NA-SALTCefotaxime free acidCEFOTAXIM SODIUM SALTCefotaxime Sodium (350 mg)Cefotaxime for peak identification
Ru-24756NSC-756666Sodium 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanateCHEBI:3498DTXCID201476109Cefotaxime and dextrose 2.4% in plastic containerCefotaxime and dextrose 3.9% in plastic containerCLAFORAN IN DEXTROSE 5% IN PLASTIC CONTAINER

데이터베이스 식별자

CAS
64485-93-4
PubChem CID
10695961
DTXSID
DTXSID4046991
ChEMBL
CHEMBL1010
ChEBI
CHEBI:3498
UNII
258J72S7TZ
EC Number
264-915-9

물성

구조 계산 물성

극성 표면적
230 Ų
수소 결합 공여자 수
2
수소 결합 수용자 수
12
회전 가능 결합 수
8
무거운 원자 수
31

실험 및 물리화학적 성질

Solubility68.2 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs · 2건

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

물리화학적 성질

녹는점
162 · 162-163 C
굴절률
61 ° · 61 ° (C=1, H2O)
저장 조건
2 · Keep in dark place,Inert atmosphere,2-8°C
용해도
2 O: · H2O: pH 4.3-6.2의 수용액은 2-8 ℃에서 최대 3주 동안 안정합니다.
물리적 상태
가루
색상
흰색에서 노란색으로

화학적 성질

White to pale yellow crystalline powder

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H317 (99.2%): May cause an allergic skin reaction [Warning Sensitization, Skin]

P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 132 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory InformationCefotaxime sodium: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Sens. 1 (99.2%)

독성 정보

Drug Induced Liver Injury · 6건

Drug Induced Liver Injury Rank (DILIrank 2.0)

Cefotaxime sodium

vLess-DILI-concern

5

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

안전 데이터

wgk
2
rtecs
XI0250000
HS 번호
29419000
risk_code
42/43
hazard_code
Xn,Xi
safety_code
22-36/37-60-45-37-24

화학 및 산업

약리 정보

FDA Pharmacological Classification · 2건

CEFOTAXIME INJECTION

Cephalosporin Antibacterial [EPC]; Cephalosporins [CS]

MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
응용 분야 · 3건

개요Cefotaxime was synthesized by Hoechst and Roussel-Uclaf in 1977. It was the first derivative of cephalosporin to introduce the methoxyimino and aminothiazole groups at the 7 position of the cephem nucleus. Although it shows unexpectedly low oral absorption, its excellent activity against a wide range of gram-positive and gram-negative organisms, including Serratia, Enterobacter, Citrobacter, and anaerobes, guided research and development of the newer synthetic cephems, the so-called thirdgeneration cephalosporins.

용도Cefotaxime sodium salt acts as a beta-lactamase resistant antibiotic. It is used as an effective antibacterial against gram-negative bacteria, with the notable exception of pseudomonas and penicillin-resistant strains of streptococcus pneumoniae. It is used to treat infections of the bones, joints, skin, respiratory tract and blood stream.

일반 설명Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

상·하류 제품 정보

하류 제품

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海如吉生物科技发展有限公司+86-21-65211385-8001 36031160 · [email protected]
北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]

추가 설명

정의ChEBI: A cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups.

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