기본 정보
- CAS
315703-52-7- 표준 SMILES
CCOc1ccc(Nc2nc(-c3c(C)nc4ccccn34)cs2)cc1- InChIKey
ROYXIPOUVGDTAO-UHFFFAOYSA-N- 분자식
- C19H18N4OS
- 평균 분자량
- 350.4 g/mol
- 단동위원소 질량
- 350.12013238
개요
structure in first source
이름 및 식별자
- 우선 이름
- JK184
- IUPAC
- N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine
- 영어명
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- 분자식
- C19H18N4OS
- 분자량
- 350.44
이름 및 동의어
315703-52-7JK184RefChem:150500683-690-1N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amineJK 184JK-184N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amineN-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamineMFCD01044465CHEMBL514622N-(4-ETHOXYPHENYL)-4-{2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-YL}-1,3-THIAZOL-2-AMINE
이름 더 보기
CS-2369JK184 (JK-184JK184, 10 mM in DMSOHh Signaling Antagonist VIIJK 184, Hedgehog signaling inhibitorHH SIGNALING ANTAGONIST VIIJK-184,inhibit,JK 184,JK184,Inhibitor,HedgehogHh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem
2-Thiazolamine, N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-N-(4-Ethoxyphenyl)-4-(2-methylimida zo[1,2-a]pyridin-3-yl)-2-thiazolamineN-(4-Ethoxyphenyl)-4-(2-methylimidazo-[1,2-a]pyridin-3-yl)thiazol-2-amineHh Signaling Antagonist VII, JK1842-Thiazolamine, N-(4-ethoxyphenyl)-4-(2-methylimidazo(1,2-a)pyridin-3-yl)-Oprea1_052741Oprea1_737598MLS006010845
물성
구조 계산 물성
- XLogP
- 5.1
- 극성 표면적
- 79.7 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 25
- 형식 전하
- 0
- 복잡도
- 432
물리화학적 성질
- 저장 조건
- 2 · Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- 20 mg/mL · DMSO: ≥20mg/mL
- 물리적 상태
- 가루
- 색상
- 황백색부터 연한 갈색까지
- InChI
- 1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)
- InChIKey
- ROYXIPOUVGDTAO-UHFFFAOYSA-N
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H302 (97.4%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P264+P265, P270, P280, P301+P317, P305+P354+P338, P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 4 (97.4%)
안전 데이터
- wgk
- 3
- risk_code
- 22-41
- hazard_code
- Xn
- safety_code
- 26-36
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
용도JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]
공급사63 곳
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
上海微佳禾生物科技有限公司17502176150; 17502176150 · [email protected]
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
Hangzhou Sage Chemical Co., Ltd.+86057186818502 13588463833 · [email protected]
河南阿尔法化工有限公司0371-55013243 15324716602 · [email protected]
InvivoChem中国13549236410 · [email protected]
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