기본 정보
- CAS
644-26-8- 표준 SMILES
CCC(C)(CN(C)C)OC(=O)c1ccccc1- InChIKey
FDMBBCOBEAVDAO-UHFFFAOYSA-N- 분자식
- C14H21NO2
- 평균 분자량
- 235.32 g/mol
- 단동위원소 질량
- 235.15722891
개요
Stovaine is a benzoate ester.
이름 및 식별자
- 우선 이름
- Amylocaine
- IUPAC
- [1-(dimethylamino)-2-methylbutan-2-yl] benzoate
- 현지명
- 1-다이메틸아미노메틸-1-메틸프로필벤조에이트
- 영어명
- 1-[(dimethylamino)methyl]-1-methylpropyl benzoate
- 분자식
- C14H21NO2
- 분자량
- 235.32
이름 및 동의어
AmylocaineStovaine644-26-8QRW683O56T1-(DIMETHYLAMINO)-2-METHYL-2-BUTANOL BENZOATEDTXSID6047862(1-((dimethylamino)methyl)-1-methyl-propyl) benzoate[1-[(dimethylamino)methyl]-1-methyl-propyl] benzoateRefChem:557965DTXCID2027838211-411-1Amyleine
이름 더 보기
1-다이메틸아미노메틸-1-메틸프로필벤조에이트1-다이메틸아미노메틸-1-메틸프로필벤조에이트(아밀로카인)및그염류아밀로카인1-[(디메틸아미노)메틸]-1-메틸프로필벤조에이트Stovain2-Butanol, 1-(dimethylamino)-2-methyl-, 2-benzoateBenzoic acid 1-[(dimethylamino)methyl]-1-methylpropyl ester
Amylocaine [BAN]1-(Dimethylamino)-2-methylbutan-2-yl benzoate[1-(dimethylamino)-2-methylbutan-2-yl] benzoateEINECS 211-411-1Amylocaine (BAN)1-[(Dimethylamino)methyl]-1-methylpropyl benzoate1-((Dimethylamino)methyl)-1-methylpropyl benzoate2-Butanol, 1-(dimethylamino)-2-methyl-, benzoate
데이터베이스 식별자
- CAS
644-26-8- PubChem CID
- 10767
- DTXSID
DTXSID6047862
물성
구조 계산 물성
- XLogP
- 3
- 극성 표면적
- 29.5 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 17
- 형식 전하
- 0
- 복잡도
- 247
실험 및 물리화학적 성질
Human DrugsPharmaceuticals
물리화학적 성질
- 끓는 점
- 377.72 °C · 377.72°C (rough estimate)
- 밀도
- 1.0247 · 1.0247 (rough estimate)
- 굴절률
- 1.5385 · 1.5385 (estimate)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- 독성
- LDLo ivn-rat: 25 mg/kg PHREA7 12,262,32
화학 및 산업
약리 정보
Protein BindingA lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
Pharmacodynamics
Like all other local anesthetics, amylocaine acts as a membrane stabilizing drug that reversibly decreases the rate of depolarization and depolarization of excitable membranes. In this way, the conduction of neuronal signals for certain bodily movements can be blocked. In particular, when administered for spinal anesthesia, the resultant anesthesia can typically extend from the chest to the legs.
Mechanism of Action
In particular, amylocaine, much like other local anesthetics, bind and blockade voltage gated sodium channels located in the excitable membranes of various sensory receptors. Once blocked, the influx of sodium across the channels and membrane is inhibited. Because the influx of sodium is necessary to facilitate neuronal action potentials and signal conduction across sensory receptor membranes, the influx inhibition subsequently prevents the body reactions that would normally result from the neuronal signals.
Biological Half-LifeA lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
Metabolism/MetabolitesA lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
Absorption, Distribution and Excretion
A lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
A lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
A lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
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