Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
푸미트레모긴A
푸미트레모긴A · FUMITREMORGENA · Fumitremorgin A · A Fumitremorgin A · Fumitremorgin A / Fumitremorgen A · 5H,12H-3,4-Dioxa-5a,11a,15a-triazacyclooct[lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione, 1,10,10a,14,14a,15b-hexahydro-10a-hydroxy-7-methoxy-2,2-dimethyl-10-[(3-methyl-2-buten-1-yl)oxy]-5-(2-methyl-1-propen-1-yl)-, (5R,10S,10aR,14aS,15bS)-
식별자 및 물리적 특성
| CAS No. | 12626-18-5 |
|---|---|
| 분자식 | C32H41N3O7 |
| 평균 분자량 | 579.7 g/mol |
| 단동위원소 질량 | 579.29445066 g/mol |
| SMILES | COc1ccc2c3c4n(c2c1)[C@@H](C=C(C)C)OOC(C)(C)C[C@@H]4N1C(=O)[C@@H]2CCCN2C(=O)[C@]1(O)[C@H]3OCC=C(C)C |
| InChIKey | ACGHJVZDNQZJOV-BMOJZYMJSA-N |
| PubChem CID | 107713 |
| ChEBI | CHEBI:72766 |
| DTXSID | DTXSID30925479 |
| 현지명 | 푸미트레모긴A |
화학 및 물리적 성질
| XLogP | 3.8 |
|---|---|
| 극성 표면적 | 103 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 7 |
| 회전 가능 결합 수 | 5 |
| 무거운 원자 수 | 42 |
| 형식 전하 | 0 |
| 복잡도 | 1,150 |
| 끓는 점 | 762.1±60.0 °C(Predicted) |
| 밀도 | 1.34±0.1 g/cm3(Predicted) |
| pKa(산도 계수) | 10.53±0.70(Predicted) |
안전 및 규제
| Treatment | To control severe tremors caused by tremorgenic mycotoxins, methocarbamol should be administered. Generalized seizures may be treated with diazepam followed by methocarbamol or a barbiturate such as pentobarbital sodium. Gastric lavage should be performed and activated charcoal administered to limit further absorption of toxins. (A744) |
|---|---|
| 건강 영향 | Tremorgenic mycotoxins affect central nervous system activity. They cause a neurological disease of cattle known as "staggers syndrome". (A2976) |
| 노출 경로 | Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) |
| 독성 요약 | Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. (A2974, A2975, A2976) |
| Signs and Symptoms | Tremorgenic mycotoxins affect central nervous system activity, inducing neurologic symptoms including mental confusion, paralysis, tremors, seizures, and death. They cause a neurological disease of cattle known as "staggers syndrome", which is characterized by muscle tremors and hyperexcitability. Fumitremorgin A exposure has also been shown to cause bradycardia, arrhythmia, and hypertension. (A2974, A3025) |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
용도
출처
A tremorgenic toxin isolated as a metabolite of AspergillusJurnigatus. It is highly toxic.