기본 정보
- CAS
91037-65-9- 표준 SMILES
NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O- InChIKey
NNRFRJQMBSBXGO-CIUDSAMLSA-N- 분자식
- C15H27N7O8
- 평균 분자량
- 433.42 g/mol
- 단동위원소 질량
- 433.19211085
개요
Arg-Gly-Asp-Ser peptide is an organic molecular entity. It has a role as an anti-inflammatory agent.
이름 및 식별자
- 우선 이름
- Fibronectin tetrapeptide
- IUPAC
- (3S)-3-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid
- 영어명
- Arg-Gly-Asp-Ser
- 분자식
- C15H27N7O8
- 분자량
- 433.42
이름 및 동의어
Arg-gly-asp-ser91037-65-9Rgds peptideFibronectin tetrapeptideArginyl-glycyl-aspartyl-serineAC6UDA2MFCL-Serine, L-arginylglycyl-L-alpha-aspartyl-RefChem:113929RGDSH-Arg-Gly-Asp-Ser-OHMFCD00076452CHEMBL265628
이름 더 보기
RGDS - 5 mgRGDS 1/2ACOH 2H2OL-ARG-GLY-ASP-SERArg-Gly-Asp-Ser-OHRGDS/ARG-GLY-ASP-SERFIBRONECTIN INHIBITOR
C15H27N7O8(3S)-3-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acidHY-12290C77102Q27273860(S)-3-[2-((S)-2-Amino-5-guanidino-pentanoylamino)-acetylamino]-N-((R)-1-carboxy-2-hydroxy-ethyl)-succinamic acidL-Arginylglycyl-L-alpha-aspartyl-L-serineUNII-AC6UDA2MFC
데이터베이스 식별자
- CAS
91037-65-9- PubChem CID
- 107775
- DTXSID
DTXSID50920002- ChEMBL
CHEMBL265628
물성
구조 계산 물성
- XLogP
- -7.3
- 극성 표면적
- 273 Ų
- 수소 결합 공여자 수
- 9
- 수소 결합 수용자 수
- 10
- 회전 가능 결합 수
- 14
- 무거운 원자 수
- 30
- 형식 전하
- 0
- 복잡도
- 665
물리화학적 성질
- 녹는점
- 183 · 183-187℃
- 밀도
- 1.65 · 1.65±0.1 g/cm3(Predicted)
- 저장 조건
- -20 °C · -20°C
- 용해도
- 21.65 mg/mL · ≥21.65 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO
- 산도 계수 (pKa)
- 2.84 · 2.84±0.10(Predicted)
- 물리적 상태
- 백색 내지 회백색 분말
- 색상
- White to off-white
- 생물학적 소스
- synthetic
- 수용성
- 1 mg/ml로 · 1mg/ml로 물에 용해됨
- InChIKey
- NNRFRJQMBSBXGO-CIUDSAMLSA-N
- SMILES
- N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
응용 분야
용도Arg-Gly-Asp-Ser has been used:to study its effects on cell attachment in ratsto analyse the interaction of fibrinogen with erythrocytes occurs through integrin related receptorto pretreat the cells, to assess the role of integrin in the cell attachment processto test its competition with platelet-secreted, nanosheet-adsorbed proteins for binding to glycoprotein IIIa (GPIIIa)
일반 설명The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor 1 (TGF1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstratedto mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages
상·하류 제품 정보
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