Dodma

HCID 11181107

노트 반응

부분 구조 검색 유사 구조 찾기

기본 정보

CAS: 104162-47-2
표준 SMILES: CCCCCCCC/C=C\CCCCCCCCOCC(CN(C)C)OCCCCCCCC/C=C\CCCCCCCC
InChIKey: GLGLUQVVDHRLQK-WRBBJXAJSA-N
분자식: C41H81NO2
평균 분자량: 620.1 g/mol

이름 및 식별자

우선 이름: Dodma
IUPAC: N,N-dimethyl-2,3-bis[(Z)-octadec-9-enoxy]propan-1-amine
영어명: DODMA
분자식: C41H81NO2
분자량: 620.09

이름 및 동의어

DODMA104162-47-2U587H2R5YRRefChem:10839701,2-dioleyloxy-3-dimethylamino-propaneN,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine1,2-dioleyloxy-3-(dimethylamino)propane2,3-dioleyloxy-1-(dimethylamino)propaneN,N-dimethyl-2,3-bis[(Z)-octadec-9-enoxy]propan-1-amineMFCD222009911-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]-N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine

이름 더 보기

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA)R-DODMAMBN 305A98.0% (TLC)2-amino-2,3-dimethyloleanol1,2-dioleoxy-3-dimethylamino-propane (DODMA)2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC)

C41H81NO2DODMA?starbld0000782SCHEMBL26459MBN-305Aorb1962278GLGLUQVVDHRLQK-WRBBJXAJSA-N{2,3-BIS[(9Z)-OCTADEC-9-EN-1-YLOXY]PROPYL}DIMETHYLAMINE

데이터베이스 식별자

CAS: 104162-47-2
PubChem CID: 11181107
UNII: U587H2R5YR
Nikkaji: J3.757.798G

물성

구조 계산 물성

XLogP: 15.8
극성 표면적: 21.7 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 3
회전 가능 결합 수: 37
무거운 원자 수: 44
형식 전하: 0
복잡도: 573

물리화학적 성질

끓는 점: 649.7 · 649.7±55.0 °C(Predicted)
밀도: 0.869 · 0.869±0.06 g/cm3(Predicted)
저장 조건: -20 °C · -20°C
용해도: Soluble in Ethanol, DMSO, DMF
산도 계수 (pKa): 8.65 · 8.65±0.28(Predicted)
물리적 상태: Liquid
색상: Colorless to light yellow
생물학적 소스: synthetic
BRN: 10139013 · 10139013
InChIKey: GLGLUQVVDHRLQK-WRBBJXAJSA-N
SMILES: C(N(C)C)C(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC

안전 및 규제

안전 데이터

wgk: 3
스토리지 클래스: 10 - Combustible liquids

화학 및 산업

응용 분야 · 2건

개요1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.

용도DODMA is responsible for the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA useful for silencing disease-causing genes in hepatocytes following i.v. administration.