Silver acetate

Silver acetate is a white crystalline plates. Light sensitive. Density 3.26 g / cm3.

Liquid; Other Solid

White to slightly gray solid; Soluble in 100 parts cold water; [Merck Index] Solubility in water = 10 g/L; [ChemIDplus] Beige powder; [Aldrich MSDS]

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 57 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Chemical: Acetic acid, silver(1+) salt

Acetic acid, silver(1+) salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, silver(1+) salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Silver acetate: Does not have an individual approval but may be used under an appropriate group standard

Sensitive to light; [Merck Index] No evidence of developmental toxicity or teratogenicity in rats dosed by gavage on gestation days 6-19 (even at doses maternally toxic); NOAEL for maternal toxicity was 10 mg/kg/day and 100 mg/kg/day for developmental toxicity; [NTP] Dust is irritating to eyes, nose, and throat; Solid irritates skin and eyes; [CHRIS] Caused effects to metabolism and plasma proteins in 4-day intermittent study of rats (641 mg/kg); [RTECS] A skin and strong eye irritant; May cause argyria; [Aldrich MSDS] See Silver.

10 mg Ag/m3 (NIOSH, 2024)

10.0 [mg/m3], as Ag

Silver itself is not toxic to humans, but most silver salts are. In large doses, silver and compounds containing it can be absorbed into the circulatory system and become deposited in various body tissues, leading to argyria, which results in a blue-grayish pigmentation of the skin, eyes, and mucous membranes. Argyria is rare, and although, so far as known, this condition does not otherwise harm a person's health, it is disfiguring and usually permanent. Mild forms of argyria are sometimes mistaken for cyanosis. (L809)

Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions and intracellular ion concentrations, respectively. Silver nanoparticles are believed to disrupt the mitochondrial respiratory chain, causing oxidative stress, reduced ATP synthesis, and DNA damage. (L808, A243, A244, A245, A246)

Exposure to high levels of silver for a long period of time may result in a condition called arygria, a blue-gray discoloration of the skin and other body tissues. Argyria is a permanent effect but does not appear to be harmful to health. Exposure to high levels of silver in the air has resulted in breathing problems, lung and throat irritation, and stomach pains. Skin contact with silver can cause mild allergic reactions such as rash, swelling, and inflammation in some people. (L808)

Silver and its compounds can be absorbed via inhalation, while silver compounds can also be absorbed orally and dermally. It distributes throughout the body in the blood, particularily to the liver. Insoluble silver salts are transformed into soluble silver sulfide albuminates, bind to amino or carboxyl groups in RNA, DNA, and proteins, or are reduced to metallic silver by ascorbic acid or catecholamines. Metallic silver is oxidized and may deposit in the tissues, causing arygria. Silver is eliminated primarily in the faeces. (L808)

Used in liquid ammonia (oxidizing agent); [Merck Index] Used in anti-smoking remedies; [EPA REDs] Used as a laboratory reagent and oxidizing agent; [Hawley]

Silver acetate is commonly used as a pesticide. It also produces a repulsive taste when combined with cigarette smoke, so it is used in chewing gum and lozenges to aid the cessation of smoking. (L813)

All Other Chemical Product and Preparation Manufacturing

Acetic acid, silver(1+) salt (1:1): ACTIVE