기본 정보
- CAS
82-88-2- 표준 SMILES
CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12- InChIKey
ISFHAYSTHMVOJR-UHFFFAOYSA-N- 분자식
- C19H19N
- 평균 분자량
- 261.4 g/mol
- 단동위원소 질량
- 261.15174961
개요
Phenindamine is an indene.
이름 및 식별자
- 우선 이름
- Phenindamine
- IUPAC
- 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
- 영어명
- phenindamine
- 분자식
- C19H19N
- 분자량
- 261.36
이름 및 동의어
PhenindamineThephorin82-88-2FenindaminaPhenindaminum772BQ8KSSTNU-15042,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridine1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-DTXSID00234521H-Indeno[2,1-c]pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno[2,1-c]pyridine
이름 더 보기
phenindamine USP/EP/BPPhenindamine Hydrogen Tartrate2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine1H-Indeno2,1-cpyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-
2-METHYL-9-PHENYL-1H,2H,3H,4H,9H-INDENO[2,1-C]PYRIDINE2-methyl-9-phenyl-1H,2H,3H,4H,9H-indeno(2,1-c)pyridineRefChem:172693DTXCID403452R06AX042,3,4,9-tetrahydro-2-methyl-9-phenyl-lH-indeno-(2,1-c)pyridine201-443-4Fenindamina [INN-Spanish]
데이터베이스 식별자
- CAS
82-88-2- PubChem CID
- 11291
- DTXSID
DTXSID0023452- ChEMBL
물성
구조 계산 물성
- XLogP
- 3.1
- 극성 표면적
- 3.2 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 1
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 20
- 형식 전하
- 0
- 복잡도
- 391
실험 및 물리화학적 성질
Solubility2.77e-02 g/L
Human Drugs
Breast Feeding; Lactation; Milk, Human; Antihistamines
Pharmaceuticals
Melting Point91 °C
Physical DescriptionSolid
물리화학적 성질
- 녹는점
- 90 · 90-91°
- 밀도
- 1.17 · 1.17
- 산도 계수 (pKa)
- 8.11 · pKa 8.11±0.08(H2O,t undefined,I=0.30(NaCl)) (Uncertain)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Regulatory Information1H-Indeno2,1-cpyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-: Does not have an individual approval but may be used under an appropriate group standard
독성 정보
Toxicity Summary
Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Signs and SymptomsSymptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
화학 및 산업
약리 정보
ATC Code
R - Respiratory system
QR - Respiratory system
Pharmacodynamics
Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Allergies are caused by an excessive type 1 hypersensitivity response of the body to allergens, mediated by inappropriate histamine signalling. By inhibiting the binding of histamine, antihistamines decrease the normal histamine response from cells, consequently decreasing allergic symptoms.
Mechanism of Action
Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
MeSH Pharmacological Classification
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Cellular LocationsMembrane
Metabolite PathwaysPhenindamine H1-Antihistamine Action
용도 및 제조
UsesUsed to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.
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