트라이메틸아민(트리메틸아민)
N,N-디메틸메타나민 · N,N-디메틸메탄아민N,N-DIMETHYLMETHANAMINE · 트라이메틸아민(트리메틸아민) · 트리메틸아민 · 트리메틸아민30% · N,N-디메틸메탄아민 · 트라이메틸아민 · Methylamine, N,N-dimethyl-
식별자 및 물리적 특성
| CAS No. | 75-50-3 |
|---|---|
| 분자식 | C3H9N |
| 평균 분자량 | 59.11 g/mol |
| 단동위원소 질량 | 59.07349929 g/mol |
| SMILES | CN(C)C |
| InChIKey | GETQZCLCWQTVFV-UHFFFAOYSA-N |
| PubChem CID | 1146 |
| ChEMBL | CHEMBL439723 |
| ChEBI | CHEBI:18139 |
| EC No. | 200-875-0 |
| DTXSID | DTXSID2026238 |
| 현지명 | 트라이메틸아민(트리메틸아민) |
화학 및 물리적 성질
| XLogP | 0.3 |
|---|---|
| 극성 표면적 | 3.2 |
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 1 |
| 회전 가능 결합 수 | 0 |
| 무거운 원자 수 | 4 |
| 형식 전하 | 0 |
| 복잡도 | 8 |
| 물질 분류 | Nitrogen Compounds -> Amines, AliphaticFlammable agents - 4th degree |
| 의약품 | Pharmaceuticals -> Metabolite of Levocarnitine |
| pH | Strong basea strong base (pH 9.8) |
| SpringerMaterials Properties | 15N nuclear magnetic resonance spectrum |
| 향료 | Fragrance Ingredient (Trimethylamine) -> IFRA transparency List |
| LogP(분배 계수) | log Kow = 0.160.2-0.3 |
| 냄새 | Pungent, fishy, ammoniacalFishy, amine odorA fish-like odor at low concentrations changing to an ammonia-like odor at higher concentrations.썩어가는 생선 냄새, 썩은 달걀 냄새, 쓰레기 냄새, 소변 냄새가 납니다. |
| 맛 | Old fishSaline taste |
| 식품 첨가물 | FLAVORING AGENT OR ADJUVANT -> FDA Substance added to food |
| 밀도 | 0.633 at 68 °F (USCG, 1999) - Less dense than waterwill float0.6356 (NTP, 1992) - Less dense than water0.6709 at 0 °C/4 °CSaturated liquid density= 40.890 lb/cu ft @ 35 °CSaturated vapor density= 0.29910 lb/cu ft @ 70 °CRelative density (water = 1): 0.6 (liquid)0.63 g/mL at 20 °C (lit.) |
| 향미제 | EU Flavoring substances |
| Viscosity | 5.1564X10-4 Pa.sec at 200 K |
| 녹는점 | -117 °C (lit.) |
| 끓는 점 | 3-4 °C (lit.) |
| 증기 밀도 | 2.09 (vs air) |
| 증기압 | 430 mm Hg ( 25 °C) |
| 굴절률 | n20/D 1.357 |
| FEMA | 3241 | TRIMETHYLAMINE |
| 인화점 | 38 °F |
| 저장 조건 | Store at +5°C to +30°C. |
| 용해도 | 물에 매우 잘 녹고, 알코올, 에테르, 벤젠, 톨루엔, 자일렌, 에틸벤젠, 클로로포름에 약간 녹습니다. 최대 허용 농도: TLV 10ppm(24mg/m3) 및 STEL 15ppm(36mg) /m3) (ACGIH 1986) |
| 물리적 상태 | 액체 |
| pKa(산도 계수) | pKb (25°): 4.13 |
| 색상 | 무색의 |
| 향취 유형 | 비린내 |
| 생물학적 소스 | synthetic |
| 폭발한계 | 11.6% |
| 후각 역치 | 0.000032ppm |
| 용해도 | 물에 불용성, 8.9e+005mg/L. |
| 비열 | Cp(liquid): 2.33 J/(g·K)Cp(gas): 1.55 J/(g·K), at 25℃ |
| Merck | 14,9710 |
| JECFA Number | 1610 |
| BRN | 956566 |
| 헨리 상수 | 9.9×10-2 mol/(m3Pa) at 25℃, Burkholder et al. (2019) |
| 유전율 | 2.9(4℃) |
| 안정성 | Stable. Incompatible with a wide variety of materials, including bases, acids, oxidizing agents, brass, zinc, magnesium, aluminium, mercury, mercury oxides, acid chlorides, acid anhydrides. Hygroscopic. Highly flammable. Readily forms explosive mixtures with air. |
| InChI | 1S/C3H9N/c1-4(2)3/h1-3H3 |
| InChIKey | GETQZCLCWQTVFV-UHFFFAOYSA-N |
| SMILES | CN(C)C |
| LogP(분배 계수) | 0.06 |
| EPA | Trimethylamine (75-50-3) |
화학적 성질
Trimethylamine is compressed gas or liquid. Flammable gas. Shipped as a compressed gas, it may be present in an aqueous solution. It has a strong, fishy, ammoniacal odor. The Odor Threshold is 0.00011-0.87 ppm. Warning: The Odor Threshold range is so broad that odor alone should not be used as a warning of potentially hazardous exposures.
안전 및 규제
| GHS 분류 | DangerH220: Extremely flammable gas [Danger Flammable gases]P203, P210, P222, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P377, P381, P403, P403+P233, P405, and P501 (click each P-code to see the statement)H224: Extremely flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) |
|---|---|
| 규제 정보 | Chemical: Methanamine, N,N-dimethyl-Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)Methanamine, N,N-dimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methanamine, N,N-dimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 08-09-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14936Trimethylamine, anhydrous: HSNO Approval: HSR001014 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| 운송 라벨(DOT) | Flammable GasFlammable Liquid Corrosive |
| 화재 위험 | FLAMMABLE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. Vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back. (USCG, 1999)Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:· Flammable/combustible material.· EXTREMELY FLAMMABLE.Extremely flammable. Gives off irritating or toxic fumes (or gases) in a fire. Gas/air mixtures are explosive.Extremely flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive. |
| 화재 가능성 | Flammable gas.A very dangerous fire hazard when exposed to heat or flame. |
용도
용도
소독제 원료 따위로 쓰인다.
출처
TMA is widely distributed in the environment as a normal constituent of animal and plant tissue and as a result of its formation during the decay of organic matter in plants, animals, fish, sewage and animal waste (Graedel 1978; Hippe et al 1977; Oremland et al 1982). The amine is formed primarily as the result of microbial degradation of the plant and animal constituents betaine and choline and from bacterial reduction of trimethylamine oxide, a common constituent of aquatic organisms. It also occurs naturally in a variety of foodstuffs and in tobacco smoke and these are the most likely sources of human exposure (HSDB 1988).Numerous strains of bacteria isolated from various sources have been found capable of growing on TMA (HSDB 1988). Degradation products formed under anaerobic conditions include dimethylamine, formaldehyde, formate and C02, while under aerobic conditions, TMA is converted to dimethylamine, ammonia and methane.
용도
Trimethylamine is used as a warning agent for natural gas, a synthetic flavor (fish) ingredient, and in the synthesis of photochemicals, choline salts, flotation agents, dyes, pesticides, ion-exchange resins, cationic starches, and intense sweeteners (HSDB 2006). Organic synthesis, especially of choline salts, warning agent for natural gas, manufacture of disinfectants, flotation agent, insect attractant, quaternary ammonium compounds, plastics.
일반 설명
A colorless gas with a fishlike odor at low concentrations changing to ammonia-like odor at higher concentrations. Shipped as a liquid under its own vapor pressure. Contact with the unconfined liquid can cause frostbite from evaporative cooling or chemical type burns. The gasis corrosive and dissolves in water to form flammable, corrosive solutions. Gas is an asphyxiate by the displacement of air. Produces toxic oxides of nitrogen during combustion. Prolonged exposure to heat can cause the containers to rupture violently and rocket. Long-term inhalation of low concentrations or short -term inhalation of high concentrations has adverse health effects.
제조 및 합성 방법
제조 방법
Trimethylamine can be synthesized from paraformaldehyde and ammonium chloride, by the reaction of formic acid, formaldehyde, and ammonia, and by interaction of methanol and ammonia with a catalyst at high temperature.
생산 방법
Trimethylamine (TMA) is produced by several methods: from the reaction of ammonia and methanol; from paraformaldehyde and ammonium chloride; by the action of formaldehyde and formic acid on ammonia; and by the interaction of methanol and ammonia over a catalyst at high temperature (Hawley 1981; HSDB 1988). TMA is sold as an aqueous solution or as a liquefied gas (Windholz et al 1983) in which the aqueous solution is available as 25, 30, and 40% and anhydrous as 99% minimum. The impurities consist of ammonia at no more than 0.2% by weight of solution and formaldehyde at no more than 0.3% by wt. of solution (Rick 1985). U.S. production was estimated to be approximately 15,322 tons in 1984 (HSDB 1988).