CAS 73231-34-2 Florfenicol (HCID 114811)

개요

Florfenicol is a carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture. It has a role as an antimicrobial agent. It is a secondary carboxamide, a secondary alcohol, a sulfone, an organochlorine compound and an organofluorine compound. It is functionally related to a dichloroacetic acid.

이름 및 식별자

우선 이름: Florfenicol
IUPAC: 2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
영어명: FLORFENICOL
분자식: C12H14Cl2FNO4S
분자량: 358.21

이름 및 동의어

Florfenicol73231-34-2Nuflor(-)-FlorfenicolSch-25298Sch 25298Nuflor gold2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamideDTXSID9045500Acetamide, 2,2-dichloro-N-((1S,2R)-1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)-D-threo-2,2-Dichloro-N-(alpha-(fluoromethyl)-beta-hydroxy-p-(methylsulfonyl)phenethyl)acetamide9J97307Y1H

이름 더 보기

FLORFENICALFLEROXACINLACTATEAQUAFENorfenicoLAquafen NuflorFlorfenicol APIFlorfenicol98%MinFlorfenicol, 98.5%

NSC-759287Acetamide, 2,2-dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]-DTXCID7025500CHEBI:87185OSURNIA COMPONENT FLORFENICOLZELERIS COMPONENT FLORFENICOL2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamideAquaflor

데이터베이스 식별자

CAS: 73231-34-2、76639-94-6
PubChem CID: 114811
DTXSID: DTXSID9045500
ChEMBL: CHEMBL1241590
ChEBI: CHEBI:87185
UNII: 9J97307Y1H
EC Number: 620-107-1、642-986-0
Nikkaji: J128.612I

물성

구조 계산 물성

XLogP: 0.8
극성 표면적: 91.9 Å²
수소 결합 공여자 수: 2
수소 결합 수용자 수: 5
회전 가능 결합 수: 6
무거운 원자 수: 21
형식 전하: 0
복잡도: 447

실험 및 물리화학적 성질

Drugs · 3건

Pharmaceuticals -> Antibiotics

Pharmaceuticals -> Antibiotics (Amphenicols)

Pharmaceuticals -> Anti infectives for systemic use -> Antibacterials for systemic use

LogP0.96

Animal Drugs · 2건

Active Ingredients (Florfenicol) -> FDA Greenbook

Pharmaceuticals -> UK Veterinary Medicines Directorate List

Collision Cross Section · 3건

170.7 Å² [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

169.78 Å² [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

170.95 Å² [M+Na]+

물리화학적 성질

녹는점: 153 °C · 153°C
물리적 상태: 고체

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 4% (4 of 101) of reports.

Danger

H361 (92.1%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

P203, P260, P264, P270, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 101 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.

유해성 정보

Regulatory InformationFlorfenicol: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and Categories · 2건

Acute Tox. 4 (50%)

Repr. 2 (92.1%)

안전 데이터

wgk: 3
HS 번호: 29419090
safety_code: 24/25

화학 및 산업

약리 정보

ATC Code · 2건

QJ - Antiinfectives for systemic use

MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.

용도 및 제조

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

응용 분야

용도anticholinergic, antiparkinsonian

공급사100 곳

湖北永阔科技有限公司027-59223108 15972152991 · [email protected]

湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]

湖北万得化工有限公司15377098680 15377098680 · [email protected]

湖北威德利化学试剂有限公司181-6332-1995 18062128043 · [email protected]

武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]

화합물 노트

불러오는 중…

Florfenicol

기본 정보

개요