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기본 정보
- CAS
32886-97-8- 표준 SMILES
CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](N=CN3CCCCCC3)[C@H]2SC1(C)C- InChIKey
NPGNOVNWUSPMDP-HLLBOEOZSA-N- 분자식
- C21H33N3O5S
- 평균 분자량
- 439.578 g/mol
- 단동위원소 질량
- 439.21409216
이름 및 식별자
- 우선 이름
- Pivmecillinam
- IUPAC
- [(2,2-Dimethylpropanoyl)oxy]methyl (2S,5R,6R)-6-{[(azepan-1-yl)methylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
- 영어명
- PIVMECILLINAM
- 분자식
- C21H33N3O5S
- 분자량
- 439.57
이름 및 동의어
AMDINOCILLIN PIVOXILPIVMECILLINAMPIVAMDINOCILLINPivmecillinam MonomerPIVMECILLINAM USP/EP/BP[(2,2-Dimethylpropanoyl)oxy]methyl (2S,5R,6R)-6-[(1-azepanylmethylene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate(2S,5β)-6α-[[(Hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid [2,2-dimethyl-1-oxopropoxy]methyl ester4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (2S,5R,6R)-PIVMECILLINAM IMPURITY CMETHYLENE 2,2-DIMETHYLPROPANOATE (2RS,4S)-2-[[[(HEXAHYDO-1H-AZEPIN-1-YL)METHYLENE]AMINO]METHYL]-5,5-DIMETHYLTHIAZOLIDIN-4-CARBOXYLATE EPP(CRM STANDARD)
데이터베이스 식별자
- CAS
32886-97-8- PubChem CID
- 115163
- DTXSID
DTXSID7048538- ChEMBL
CHEMBL1525183、CHEMBL1616433、CHEMBL1650818- ChEBI
CHEBI:51210- UNII
- 1WAM1OQ30B
- EC Number
- 251-276-6
- Nikkaji
물성
물리화학적 성질
- 녹는점
- 118 · 118-119 C
- 끓는 점
- 581 · 581.0±60.0 °C(Predicted)
- 밀도
- 1.3 · 1.30±0.1 g/cm3(Predicted)
- 저장 조건
- -20 °C · -20°C
- 용해도
- 5 mg/mL, · DMSO: 용해성5mg/mL, 투명(가온)
- 산도 계수 (pKa)
- 8.11 · 8.11±0.60(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- rtecs
- XI0185000
- 독성
- LD50 in mice, rats (mg/kg): 475-480, 465 i.v.; 1736-1930, 1935-2100 s.c.; 3020, 9500-10000 orally (Sato)
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-37/39
화학 및 산업
응용 분야
개요Pivmecillinam was found by a series of studies at Leo in 1969. It is a derivative of 6βformamidinopenicillanic acid and shows strong activity against gram-negative bacilli. Pivmecillinam is hydrolyzed by intestinal esterase and acts similarly to mecillinam after oral administration. Mecillinam shows weaker activity than ampicillin against gram-positive cocci but much stronger activity against a wide range of gramnegative bacilli.
용도Antibacterial.
상·하류 제품 정보
상류 원료
공급사21 곳
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