Pazopanib Hydrochloride
기본 정보
- CAS
635702-64-6- 표준 SMILES
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O.Cl- InChIKey
MQHIQUBXFFAOMK-UHFFFAOYSA-N- 분자식
- C21H24ClN7O2S
- 평균 분자량
- 474 g/mol
- 단동위원소 질량
- 473.1400719
개요
Pazopanib hydrochloride is a hydrochloride salt prepared from equimolar amounts of pazopanib and hydrochloric acid. Used for treatment of kidney cancer. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, an angiogenesis modulating agent and a vascular endothelial growth factor receptor antagonist. It contains a pazopanib(1+).
이름 및 식별자
- 우선 이름
- Pazopanib Hydrochloride
- IUPAC
- 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride
- 영어명
- Pazopanib Hydrochloride
- 분자식
- C21H24ClN7O2S
- 분자량
- 473.98
이름 및 동의어
Pazopanib hydrochloride635702-64-6pazopanib HClUNII-33Y9ANM545pazopanib monohydrochloridePazopanib (as hydrochloride)5-((4-((2,3-DIMETHYL-2H-INDAZOL-6-YL)(METHYL)AMINO)PYRIMIDIN-2-YL)AMINO)-2-METHYLBENZENESULFONAMIDE HYDROCHLORIDE33Y9ANM545CHEBI:71217DTXSID70212956NSC7377545-((4-((2,3-Dimethyl-2H-indazol-6-yl)methylamino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide monohydrochloride
이름 더 보기
Pazopanib HCICS-462ArMala786034GW-786034BGW786034 HClVotrient HCl
5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide hydrochlorideBenzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-, monohydrochloridePAZOPANIB HYDROCHLORIDE (MART.)PAZOPANIB HYDROCHLORIDE [MART.]5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide hydrochloride5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide monohydrochlorideRefChem:55813DTXCID00135447
물성
구조 계산 물성
- 극성 표면적
- 127 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 32
- 형식 전하
- 0
- 복잡도
- 717
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 290 °C · >290°C (dec.)
- 저장 조건
- Hygroscopic, Refrigerator, under inert atmosphere
- 용해도
- 아세토니트릴(약간), DMSO(약간)에 용해됨
- 물리적 상태
- 노란색 가루.
- 색상
- 흰색에서 황백색까지
- 안정성
- 흡습성
- InChIKey
- MQHIQUBXFFAOMK-UHFFFAOYSA-N
- SMILES
- CC1N(N=C2C=C(N(C3C=CN=C(NC4C=CC(C)=C(S(=O)(=O)N)C=4)N=3)C)C=CC=12)C.Cl
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H351 (16.7%): Suspected of causing cancer [Warning Carcinogenicity]
P203, P260, P264, P270, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 6 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesCarc. 2 (16.7%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Pazopanib hydrochloride
vMost-DILI-concern
8
Box warning
DOI:10.1016/j.drudis.2016.02.015
안전 데이터
- 신호 어
- Warning
- 유해·위험 문구
- 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302
화학 및 산업
약리 정보
FDA Pharmacological Classification
PAZOPANIB HYDROCHLORIDE
Protein Kinase Inhibitors [MoA]; Cytochrome P450 2D6 Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]; Cytochrome P450 2C8 Inhibitors [MoA]; Kinase Inhibitor [EPC]
응용 분야
개요Pazopanib Hydrochloride is the hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is an oral second-generation multitarget TKI developed by GSK and approved for marketing by the FDA in 2009 and the EMA in 2010. It targets the VEGFR, platelet-derived growth factor receptor, and c-kit, key proteins responsible for tumor growth and survival. It is used to treat patients with advanced RCC and advanced soft tissue sarcoma who have experienced chemotherapy. Pazopanib Hydrochloride has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, a tyrosine kinase inhibitor, and an angiogenesis-modulating agent.
상·하류 제품 정보
상류 원료
관련 반응
0건
현재 필터 조건에 해당하는 반응 기록이 없습니다.
화합물 노트
불러오는 중…