Azathioprine Sodium
기본 정보
- CAS
55774-33-9- 표준 SMILES
Cn1cnc([N+](=O)[O-])c1Sc1ncnc2[n-]cnc12.[Na+]- InChIKey
WISNYKIQFMKSDQ-UHFFFAOYSA-N- 분자식
- C9H6N7NaO2S
- 평균 분자량
- 299.25 g/mol
- 단동위원소 질량
- 299.02013792
개요
Azathioprine Sodium is the sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.
이름 및 식별자
- 우선 이름
- Azathioprine Sodium
- IUPAC
- sodium 6-(3-methyl-5-nitroimidazol-4-yl)sulfanylpurin-9-ide
- 영어명
- Azathioprine sodium
- 분자식
- C5H5N5NaS
- 분자량
- 190.18147
이름 및 동의어
Azathioprine sodium55774-33-9Imuran injectionAzathioprine sodium saltAM94R510MS1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-, sodium saltRefChem:58528Azathioprine Sodium [USP]sodium;6-(3-methyl-5-nitroimidazol-4-yl)sulfanylpurin-9-ideSodium 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)purin-9-ideUNII-AM94R510MSstarbld0014273
이름 더 보기
Trifluralin Impurity 26-(3-methyl-5-nitroimidazol-4-yl)sulfanylpurin-9-ide
orb1740381CHEMBL1200400SCHEMBL30647265WISNYKIQFMKSDQ-UHFFFAOYSA-NAzathioprine Sodium - API StandardsAZATHIOPRINE SODIUM [WHO-DD]AZATHIOPRINE SODIUM SALT [MI]AZATHIOPRINE SODIUM [ORANGE BOOK]
데이터베이스 식별자
- CAS
55774-33-9- PubChem CID
- 11529527
- ChEMBL
CHEMBL1200400- UNII
- AM94R510MS
물성
구조 계산 물성
- 극성 표면적
- 129 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 2
- 무거운 원자 수
- 20
- 형식 전하
- 0
- 복잡도
- 354
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- BCS Class
- 4 · 4
화학 및 산업
약리 정보
FDA Pharmacological Classification
AZATHIOPRINE SODIUM
Purine Antimetabolite [EPC]; Purines [CS]; Nucleosides [CS]; Nucleic Acid Synthesis Inhibitors [MoA]
MeSH Pharmacological Classification
Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)
Antimetabolites that are useful in cancer chemotherapy.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Drugs that are used to treat RHEUMATOID ARTHRITIS.
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