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기본 정보
- CAS
677772-84-8- 표준 SMILES
O=S(=O)(NC1CCC(c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1)C(F)(F)F- InChIKey
WDZVWDXOIGQJIO-UJKQEGAGSA-N- 분자식
- C19H17ClF5NO4S2
- 평균 분자량
- 517.92 g/mol
이름 및 식별자
- 우선 이름
- MRK 560
- 영어명
- MRK 560
- 분자식
- C19H17ClF5NO4S2
- 분자량
- 517.92
이름 및 동의어
MRK 560MRK-560MRK560MRK-560, 10 mM in DMSOWDZVWDXOIGQJIO-UJKQEGAGSA-NN-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamideMethanesulfonamide, N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-N-((1s,4s)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamideMRK-560,Jurkat cells,DND-41,Aβ peptides,MRK560,MRK 560,Gamma secretase,γ-secretase,T-ALL,Inhibitor,inhibit,Alzheimer’s disease,HPB-ALL
데이터베이스 식별자
- CAS
677772-84-8- PubChem CID
- 11577204
- ChEMBL
CHEMBL1091513、CHEMBL372199- EC Number
- 112-628-3
물성
물리화학적 성질
- 끓는 점
- 580.1 · 580.1±60.0 °C(Predicted)
- 밀도
- 1.57 · 1.57±0.1 g/cm3(Predicted)
- 저장 조건
- 4 °C · Store at 4°C
- 용해도
- 51.79 mg/ml · <51.79mg/ml in DMSO; <25.9mg/ml in ethanol
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 5.97 · 5.97±0.40(Predicted)
- 색상
- 하얀색
화학 및 산업
응용 분야
개요MRK-560 is a potent inhibitor of γ-secretase (IC50 = 0.65 nM). In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-β (1-40) (Aβ40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Aβ40 levels in rats (ED50s = 6 and 10 mg/kg, respectively). It also decreases brain-soluble Aβ40 and Aβ42 levels and recovers hippocampal long-term potentiation in the Tg2576 transgenic mouse model of Alzheimer''s disease.
용도MRK 560 acts as a y-secretase inhibitor that is orally bioavailable and potent and may be used in a therapeutic strategy to counter low amyloid (β) production in Alheimer’s disease.
공급사24 곳
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
上海瀚香生物科技有限公司177-54423994 17754423994 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
南京杜莱生物技术有限公司025-84699383-8003;025-846993838003-8003 18013301590 · [email protected]
上海喀露蓝科技有限公司18149758185 18149758185 · [email protected]
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