데이터를 보충하는 중입니다. 잠시 후 페이지를 새로 고치면 최신 내용을 볼 수 있습니다
기본 정보
- CAS
894804-07-0- 표준 SMILES
CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N- InChIKey
KQMPRSZTUSSXND-UHFFFAOYSA-N- 분자식
- C18H20N4O4
- 평균 분자량
- 356.382 g/mol
- 단동위원소 질량
- 356.14845512
이름 및 식별자
- 우선 이름
- JNK Inhibitor VIII
- IUPAC
- N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
- 영어명
- TCS JNK 6o
- 분자식
- C18H20N4O4
- 분자량
- 356.38
이름 및 동의어
TCS JNK 6oJNK Inhibitor VIIITCS JNK 6o(JNK Inhibitor VIII)JNK INHIBITOR VIII (TCS JNK 6O)JNK Inhibitor VIII, 10 mM in DMSOJNK,inhibit,Inhibitor,JNK Inhibitor VIIIJNK inhibitor VIII - JNK inhibitor compound 6oN-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamideBenzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
데이터베이스 식별자
- CAS
894804-07-0- PubChem CID
- 11624601
- DTXSID
DTXSID20469650- ChEMBL
CHEMBL210618
물성
물리화학적 성질
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- DMSO에 용해됨
- 물리적 상태
- 결정질 고체
- 색상
- White to off-white
- InChI
- 1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
- InChIKey
- KQMPRSZTUSSXND-UHFFFAOYSA-N
- SMILES
- N(c2nc(c(c(c2)N)C#N)OCC)C(=O)Cc1c(ccc(c1)OC)OC
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- WGK 2
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
개요c-Jun amino terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. They have been implicated in neurodegeneration, rheumatoid arthritis, inflammation, cancer, and diabetes. JNK1 and JNK2 are widely expressed throughout the body whereas JNK3 is predominantly distributed in the brain. JNK Inhibitor VIII is an aminopyridine compound that inhibits JNK1, JNK2, and JNK3 with Ki values of 2, 4, and 52 nM, respectively. It has been reported to inhibit the phosphorylation of the JNK substrate c-Jun in HepG2 cells (EC50 = 920 nM) without affecting the expression of IL-6, IL-8, or COX-2.
용도JNK Inhibitor VIII is an inhibitor shown to suppress apoptosis, caspase cleavage, and cytochrome C release.
공급사38 곳
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
山东大有药物研发有限公司[email protected] 15165037910 · [email protected]
InvivoChem中国13549236410 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
관련 반응
0건
현재 필터 조건에 해당하는 반응 기록이 없습니다.
화합물 노트
불러오는 중…