메틸이소시아나이드

메틸이소시아나이드 · METHYL ISONITRILE · CH3NC · Isocyanomethane · METHANE,ISOCYANO · METHYL ISOCYANIDE

https://huagongshe.com/ko/chemical/11646

식별자 및 물리적 특성

CAS No.	593-75-9
분자식	C2H3N
평균 분자량	41.05 g/mol
단동위원소 질량	41.0265491 g/mol
SMILES	[C-]#[N+]C
InChIKey	ZRKSVHFXTRFQFL-UHFFFAOYSA-N
PubChem CID	11646
ChEBI	CHEBI:44177
EC No.	209-806-9
DTXSID	DTXSID3075040
현지명	메틸이소시아나이드

화학 및 물리적 성질

XLogP	0
극성 표면적	4.4
수소 결합 공여자 수	0
수소 결합 수용자 수	1
회전 가능 결합 수	0
무거운 원자 수	3
형식 전하	0
복잡도	29.3
SpringerMaterials Properties	Schoenflies notation
녹는점	-45°C
끓는 점	81.65°C (estimate)
밀도	0.7424
굴절률	1.3427
저장 조건	Refrigerator, Under inert atmosphere
용해도	클로로포름, 메탄올(약간)에 용해됨
물리적 상태	기름
색상	연한 주황색에서 주황색으로
용해도	91g/L(15℃)
비열	Cp(gas): 1.29 J/(g·K), at 25℃
EPA	Methyl isocyanide (593-75-9)

안전 및 규제

GHS 분류	WarningH302 (95%): Harmful if swallowed [Warning Acute toxicity, oral]P260, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P319, P321, P330, P362+P364, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard Classes and Categories	Acute Tox. 4 (95%)
Treatment	Antidotes to cyanide poisoning include hydroxocobalamin and sodium nitrite, which release the cyanide from the cytochrome system, and rhodanase, which is an enzyme occurring naturally in mammals that combines serum cyanide with thiosulfate, producing comparatively harmless thiocyanate. Oxygen therapy can also be administered. (L97)
건강 영향	Exposure to high levels of cyanide for a short time harms the brain and heart and can even cause coma, seizures, apnea, cardiac arrest and death. Chronic inhalation of cyanide causes breathing difficulties, chest pain, vomiting, blood changes, headaches, and enlargement of the thyroid gland. Skin contact with cyanide salts can irritate and produce sores. (L96, L97)
노출 경로	Oral (L96)inhalation (L96)dermal (L96)
독성 요약	Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also known produce some of its toxic effects by binding to catalase, glutathione peroxidase, methemoglobin, hydroxocobalamin, phosphatase, tyrosinase, ascorbic acid oxidase, xanthine oxidase, succinic dehydrogenase, and Cu/Zn superoxide dismutase. Cyanide binds to the ferric ion of methemoglobin to form inactive cyanmethemoglobin. (L97)
Signs and Symptoms	Cyanide poisoning is identified by rapid, deep breathing and shortness of breath, general weakness, giddiness, headaches, vertigo, confusion, convulsions/seizures and eventually loss of consciousness. (L96, L97)

용도

Isocyanomethane can be used as porous embolization microspheres comprising drugs.