트리프록시스토로빈

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Keep container tightly closed in a dry and well-ventilated place.

Store in a cool, dry place and in such a manner as to prevent cross contamination with other pesticides, fertilizers, food, and feed. Store in original container and out of the reach of children, preferably in a locked storage area.

Store in a well-ventilated, secure area out of reach of children and domestic animals. Do not eat, drink, smoke, or apply cosmetics; wash thoroughly after handling.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

If the container is leaking or material spilled for any reason or cause, carefully sweep material into a pile. ... Do not walk through spilled material. ... In spill or leak incidents, keep unauthorized people away.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Wastes resulting from the use of this product may be disposed of on site or at an approved facility.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.

Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

For more Preventive Measures (Complete) data for Trifloxystrobin (6 total), please visit the HSDB record page.

Tolerances are established for residues of trifloxystrobin, including its metabolites and degradates, in or on the commodities in the table below. Compliance with the tolerance levels specified below is to be determined by measuring only the sum of trifloxystrobin, benzeneacetic acid, (E,E)-a-(methoxyimino)-2-[[[[1-[3-(trifluoromethyl) phenyl]ethylidene] amino]oxy]methyl]-, methyl ester, and the free form of its acid metabolite CGA-321113, (E,E)-methoxyimino-[2-[1-(3-trifluoromethyl-phenyl)-ethylideneaminooxymethyl]-phenyl]acetic acid, calculated as the stoichiometric equivalent of trifloxystrobin, in or on the commodity.[Table#6883]

Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves.

Body Protection: Complete suit protecting against chemicals. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator. For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Protective clothing: Long-sleeved shirt and long pants. Shoes plus socks. Waterproof gloves.

LD50; Species: Colinus virginianus (Bobwhite quail) oral >2000 mg/kg

LD50; Species: Anas platyrhynchos (Mallard duck) oral >2250 mg/kg

LD50; Species: Apis mellifera (Honey Bee) adult; topical, general >200 ug/bee[USEPA, Office of Pesticide Programs; Pesticide Ecotoxicity Database (2000) on alpha-(Methoxyimino)-2-[[[(E)-[1-

LC50; Species: Lepomis macrochirus (Bluegill sunfish) weight 0.51 g; Conditions: freshwater, flow through; Concentration: 54 ppb for 96 hr (95% confidence interval: 48-61 ppb) /96.4% purity/[USEPA, Office of Pesticide Programs; Pesticide Ecotoxicity Database (2000) on alpha-(Methoxyimino)-2-[[[(E)-[1-

For more Ecotoxicity Values (Complete) data for Trifloxystrobin (18 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 351.5 to 6300(2,3), indicate that trifloxystrobin is expected to have moderate to no mobility in soil(SRC). Volatilization of trifloxystrobin from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.2X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 2.55X10-8 mm Hg(4), and water solubility, 6.1X10-1 mg/L(4). Trifloxystrobin is degraded in soil under certain environmental conditions via abiotic and biotic processes; reported environmental half-lives range from 1.8 to 5 days(3,5).

AQUATIC FATE: Based on a classification scheme(1), Koc values of 351.5 to 6300(2,3), indicate that trifloxystrobin may adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 2.2X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 2.55X10-8 mm Hg(5), and water solubility, 6.1X10-1 mg/L(5). According to a classification scheme(6), a BCF of 540(7), suggests bioconcentration in aquatic organisms is high(SRC). Under certain environmental conditions trifloxystrobin is degraded in water via abiotic and biotic processes, reported environmental half-lives range from 1.8 to 5 days(3,8).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trifloxystrobin, which has a vapor pressure of 2.55X10-8 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase trifloxystrobin may be removed from the air by wet and dry deposition(SRC). Trifloxystrobin contains chromophores that absorb at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

Trifloxystrobin was detected in 1 out of 173 agricultural product samples from a local market in Japan at a concentration of 15.2 ng/g(1). Trifloxystrobin has been reported to occur in wheat, apple, cucumber, sugar beet, and other rotational crops up to 1 ug/kg, with an average between 81 to 115% remaining after 18 months of storage(2). In the United States in 1998, oranges treated with trifloxystrobin had residues of 0.04 to 0.20 mg/kg in the fruit samples 26 to 30 days after application; grapefruit had residues of 0.03 to 0.09 mg/kg in the fruit samples 30 to 36 days after application; lemons had residues of less than 0.02 to 0.15 mg/kg in the fruit samples 28 to 37 days after application; pome fruits (apples and pears) had residues of 0.03 to 0.37 mg/kg in the fruit samples 13 to 21 days after application; cherries had residues of 0.27 to 0.63 mg/kg in the fruit samples 1 to 2 days after application(2).

Residues of trifloxystrobin were detected at concentrations less than 0.10 ppm in commercial hop samples taken from Idaho, Oregon, and Washington in 2006 and 2007(1). In an FDA total diet study analyzing foods in 4 market basket studies from the fiscal year 2012, trifloxystrobin was detected in 9 of 159 food items considered to be infant and toddler foods at a range of 0.0001 to 0.0009 ppm and in 24 of 912 food items other than infant and toddler foods at a range of 0.0001 to 0.016 ppm(2). In an FDA total diet study analyzing foods in 4 market basket studies from the fiscal year 2013, trifloxystrobin was detected in 44 of 1,070 food items at a range of 0.0001 to 0.013 ppm(3).

IDENTIFICATION AND USE: Trifloxystrobin is a white powder. It is used as agricultural fungicide. HUMAN EXPOSURE AND TOXICITY: Trifloxystrobin is harmful if absorbed through skin. Prolonged or frequently repeated skin contact may cause allergic reactions in some individuals. ANIMAL STUDIES: Trifloxystrobin was considered to be of low acute toxicity by the oral route in mice and rats, by the dermal route in rabbits, and by the inhalation route in rats. Trifloxystrobin was not selectively neurotoxic following acute gavage or subchronic dietary administration in rats. There were no treatment-related effects upon the mating, fertility, or litter size in rats. It was not mutagenic in S. typhimurium strains TA98, TA100, TA102, TA1535, or TA1357, or in E. coli strain WP2 uvrA with and without metabolic activation. ECOTOXICITY STUDIES: Trifloxystrobin is toxic to nontarget aquatic organisms. Trifloxystrobin could affect the activities of antioxidant enzymes, disrupt photosynthesis in Chlorella vulgaris, and damage cellular structure. Trifloxystrobin is highly toxic to fish embryos. It is very toxic to Daphnia magna and can cause harm to D. magna at environmentally relevant concentrations. Trifloxystrobin was very highly toxic to sheepshead minnows.

/AQUATIC SPECIES/ Contamination of aquatic systems is a major environmental stress that can interfere with predator-prey interactions, altering prey or predator behavior differentially. We determined toxicity parameters of the fungicide trifloxystrobin (TFS) and examined its effects on predation rate, using a fish predator (Synbranchus marmoratus) and four anuran tadpole species as prey (Rhinella arenarum, Physalaemus santafecinus, Leptodactylus latrans, and Elachistocleis bicolor). TFS was not equally toxic to the four tadpole species, E. bicolor being the most sensitive species, followed by P. santafecinus, R. arenarum, and L. latrans. Predation rates were evaluated using different treatments that combined predator and prey exposed or not to this fungicide. TFS would alter the outcome of eel-tadpole interaction by reducing prey movements; thus, prey detection would decrease and therefore tadpole survival would increase. In addition, eels preyed selectively upon non-exposed tadpoles avoiding the exposed ones almost all throughout the period evaluated. Predation rate differed among prey species; such differences were not due to TFS exposure, but to interspecific differences in behavior. The mechanism that would explain TFS-induced reduction in predation rates remains unclear; however, what is clear is that sublethal TFS concentrations have the potential to alter prey behavior, thereby indirectly altering predator-prey interactions. In addition, we consider that predator-prey relationships are measurable responses of toxicant exposure and provide ecological insight into how contaminants modify predator-prey interactions.

/AQUATIC SPECIES/ ... To investigate fungicide toxicity, Hyalella azteca amphipods were exposed to 2 fungicide formulations, Headline and Stratego, and their active strobilurin ingredients, pyraclostrobin and trifloxystrobin. Water-only exposures resulted in similar median lethal concentration (LC50; 20-25 ug/L) values for formulations and strobilurin ingredients, suggesting that toxicity is due to strobilurin ingredients. These values were below concentrations that could occur following spray drift over embedded cropland wetlands. When fungicides were added to overlying water of sediment-water microcosms, toxicity was reduced by 500% for Headline and 160% for Stratego, compared with water-only exposures, based on the total amount of fungicide added to the systems. In addition, when fungicides were added to sediment prior to the addition of water, the reduction in toxicity was even greater, with no toxicity occurring at environmentally relevant levels. Differences in toxicity among exposure groups were explained by dissipation from water as toxicity values based on measured water concentrations were within 20% between all systems. The present study reinforces previous studies that Headline and Stratego are toxic to nontarget aquatic organisms. However, the presence of sediment is likely to ameliorate some toxicity of fungicide formulations, especially if spraying occurs prior to wetland inundation.

EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPA; ICSS Dashboard Application; Available from, as of December 8, 2016: http://actor.epa.gov/dashboard/]

Trifloxystrobin has reported values for log Koc = 3.8 (Koc = 6300) and log Koc = 3.5 (Koc = 2709)(1,2). Using US EPA guideline studies and soils from India and Germany (silty clay, clay, and sandy loam), desorption of trifloxystrobin ranged from 8.0 to 13.1%; Koc values ranged from 351.5 to 811.8(3). According to a classification scheme(4), these Koc values suggests that trifloxystrobin is expected to have moderate to no mobility in soil.

Tolerances are established for residues of trifloxystrobin, including its metabolites and degradates, in or on the commodities in the table below. Compliance with the tolerance levels specified below is to be determined by measuring only the sum of trifloxystrobin, benzeneacetic acid, (E,E)-a-(methoxyimino)-2-[[[[1-[3-(trifluoromethyl) phenyl]ethylidene] amino]oxy]methyl]-, methyl ester, and the free form of its acid metabolite CGA-321113, (E,E)-methoxyimino-[2-[1-(3-trifluoromethyl-phenyl)-ethylideneaminooxymethyl]-phenyl]acetic acid, calculated as the stoichiometric equivalent of trifloxystrobin, in or on the commodity.[Table#6884]

Timeline: Registration review decision and begin post-decision follow-up. Estimated Date: 2018.

Pesticide Fact Sheet: Name of Chemical: Trifloxystrobin; Reason for Issuance: New Chemical Registration, Date Issued: September 20, 1999.

Used as broad-spectrum fungicide for cereals, fruits, vegetables, and ornamentals; [HSDB]

Farming (Pesticides) [Category: Industry]

For trifloxystrobin (USEPA/OPP Pesticide Code: 129112) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Fungicide, seed treatment/protectant

This is a man-made compound that is used as a pesticide.

Trifloxystrobin Technical (Bayer Cropscience LP): Active ingredient: Trifloxystrobin 98.89%.

Flint Fungicide (Bayer Cropscience LP): Active ingredient: Trifloxystrobin 50.0%.

Stratego Fungicide (Bayer Cropscience LP): Active ingredient: Trifloxystrobin 11.4%; Propiconazole 11.4%.

Gem (Bayer Cropscience LP): Active ingredient: Trifloxystrobin 25.0%.

For more Formulations/Preparations (Complete) data for Trifloxystrobin (37 total), please visit the HSDB record page.