Propyl sulfone

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Emergency treatment: Divinyl sulfone; Divinyl sulfone causes lacrimation in exposed workers; It can cause burns to eyes and skin; Inhalation causes mucous membrane irritation, and ingestion causes GI irritation; Causes kidney damage in high-dose animal experiments; [HSDB] A moderate eye and mild to moderate skin irritant; Inhalation may cause headache, nausea, and vomiting; [Phillips 66 MSDS]

Following oral administration of (35S)-dipropyl sulfone to male Wistar rats (4.24 mmol/kg body wt), the only radioactive component subsequently found in the blood and bile was the sulfone. Biliary excretion played an important role in the elimination of this compound, with 16% of the dose excreted during the first twenty-four hours and 33% passing through the bile duct over a two day period. Bile/plasma concentration ratios remained constant during the first day (c. 46-fold), suggesting that a concentration process was taking place and that active transport of this low molecular weight compound into the bile was occurring.