기본 정보
- CAS
607-30-7- 표준 SMILES
ONc1cccc2ccccc12- InChIKey
CWFINLADSFPMHF-UHFFFAOYSA-N- 분자식
- C10H9NO
- 평균 분자량
- 159.18 g/mol
- 단동위원소 질량
- 159.06841391
개요
N-hydroxynaphthalen-1-amine is a N-substituted amine. It is functionally related to a 1-naphthylamine.
이름 및 식별자
- 우선 이름
- N-hydroxy-1-naphthalenamine
- IUPAC
- N-naphthalen-1-ylhydroxylamine
- 현지명
- N-히드록시-1-나프틸아민
- 영어명
- N-hydroxy-1-naphthylamine
- 분자식
- C10H9NO
- 분자량
- 159.18
이름 및 동의어
1-NAPHTHYLHYDROXYLAMINEN-Hydroxy-1-naphthylamineN-Hydroxy-1-naphthalenamine1-Hydroxyaminonaphthalenealpha-Naphthylhydroxylamine607-30-7N-1-NaphthylhydroxylamineHydroxylamine, N-1-naphthyl-1-Naphthalenamine, N-hydroxy-5O045G232PDTXSID40209510RefChem:76546
이름 더 보기
N-히드록시-1-나프틸아민N-(1-Naphtyl)hydroxylamine(Z)-naphthalen-1(8aH)-one oxiMe
DTXCID90132001N-Hydroxy-1-aminonaphthaleneN-(naphthalen-1-yl)hydroxylamineN-naphthalen-1-ylhydroxylamineN-hydroxynaphthalen-1-amineCCRIS 1175HSDB 2142BRN 2638939
데이터베이스 식별자
- CAS
607-30-7- PubChem CID
- 11828
- DTXSID
DTXSID40209510- ChEMBL
CHEMBL261899- ChEBI
CHEBI:34871- UNII
- 5O045G232P
- Nikkaji
- J2.985H
물성
구조 계산 물성
- XLogP
- 2.4
- 극성 표면적
- 32.3 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 12
- 형식 전하
- 0
- 복잡도
- 149
실험 및 물리화학적 성질
Chemical ClassesNitrogen Compounds -> Naphthylamines
물리화학적 성질
- 녹는점
- 79 °C · 79°C
- 끓는 점
- 284.68 °C · 284.68°C (rough estimate)
- 밀도
- 1.1202 · 1.1202 (rough estimate)
- 굴절률
- 1.546 · 1.5460 (estimate)
- 산도 계수 (pKa)
- 9 · 9.00±0.30(Predicted)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Hazards SummaryA strong eye and mucous membrane irritant; A corrosive substance that may cause damage to skin; [HSDB] Tumorigenic; [RTECS] See beta-Naphthylamine and alpha-Naphthylamine.
독성 정보
Adverse EffectsDermatotoxin - Skin burns.
Human Toxicity Excerpts
...CORROSIVE TO SKIN & HIGHLY IRRITANT TO EYES & MUCOUS MEMBRANES. REPEATED EXPOSURE MAY ENHANCE ALLERGIC REACTION PARTICULARLY OF BACK OF HANDS & FOREARMS FROM 1-2 WK TO 2-5 YR AFTER COMMENCEMENT OF EXPOSURE & CASES OF ECZEMA...FOLLOWING PROLONGED CONTACT. ... NO CASES OF SYSTEMIC POISONING...IN WORKERS. /HYDROXYLAMINE/
/HYDROXYLAMINE IS/ ABOUT EQUIPOTENT TO NITRITE AS METHEMOGLOBIN FORMER, BUT IT HAS GREATER TENDENCY TO PRODUCE SULFHEMOGLOBIN, HEINZ BODIES & OTHER IRREVERSIBLE RED CELL DAMAGE. /PRC: N-1-NAPHTHYLHYDROXYLAMINE IS NOT EXPECTED TO CAUSE EXTENSIVE METHEMOGLOBIN WHEN COMPARED TO HYDROXYLAMINE./ ... SYSTEMIC POISONING CHARACTERIZED BY CYANOSIS, CONVULSIONS & COMA. /HYDROXYLAMINE/
Non-Human Toxicity Excerpts
/HIGH CONCN/ IN ANIMALS...CAUSES CONVULSIONS FOLLOWED BY PARALYSIS & DEATH FROM CESSATION OF BREATHING... CHRONIC ABSORPTION OF MODERATE DOSES (1 MG/KG) MAY LEAD TO SLIGHT ANEMIA. /HYDROXYLAMINE/
...INHIBITOR OF CATALASE &...WHEN ADMIN PARENTERALLY, 40 MG CAUSING CONVULSIONS, NYSTAGMUS & DEATH IN RABBIT. LOCAL APPLICATION OF 10% SOLN...TO RABBIT EYES...CAUSED MODERATE INFLAMMATION OF CONJUNCTIVA. /HYDROXYLAMINE/
HYDROXYLAMINE ELEVATES BRAIN GABA /GAMMA-AMINOBUTYRIC ACID/ LEVELS IN RATS. /HYDROXYLAMINE/
CHEMICAL SYNTHESIS OF 1-NAPHTHYLHYDROXYLAMINE SHOWED THAT THIS COMP IS TUMORIGENIC IN /RATS/ & MORE POTENT THAN 2-NAPHTHYLHYDROXYLAMINE. NEITHER COMPD INDUCES BLADDER TUMORS IN /RATS/ BUT BOTH CAUSE LIVER TUMORS.
For more Non-Human Toxicity Excerpts (Complete) data for 1-NAPHTHYLHYDROXYLAMINE (6 total), please visit the HSDB record page.
안전 데이터
화학 및 산업
약리 정보
Mechanism of ActionTHE CARCINOGEN N-HYDROXY-1-NAPHTHYLAMINE REACTED WITH NUCLEIC ACID & PROTEIN UNDER SLIGHTLY ACIDIC CONDITIONS (PH5) TO FORM COVALENTLY BONDED DERIV WITH 3 TO 20 NAPHTHYL RESIDUES/1000 MONOMER UNITS.
공급사2 곳
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
上海指月生物科技有限公司13918644899 · [email protected]
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