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HCID 11933생성일: 2026년 10월 27일

3,3'-다이클로로벤지딘 이수화염화물

3,3'-다이클로로벤지딘이수화염화물 · 3,3'-다이클로로벤지딘다이하이드로클로라이드 · 3,3'-다이클로로벤지딘 다이하이드로클로라이드 · 3,3'-디클로로벤지딘 염화물 · 3,3'-DICHLOROBENZIDINE 2HCL · 3,3-DICHLOROBENZIDINE DIHYDROCHLORIDE · 33DCBH · 3,3'-Dichlorobenzidi

https://huagongshe.com/ko/chemical/11933

3,3'-다이클로로벤지딘 이수화염화물 분자 구조식

식별자 및 물리적 특성

CAS No.612-83-9
분자식C12H10Cl2N2.2ClH
평균 분자량326 g/mol
단동위원소 질량323.9754591 g/mol
SMILESCl.Cl.Nc1ccc(-c2ccc(N)c(Cl)c2)cc1Cl
InChIKeyBXAONUZFBUNTQR-UHFFFAOYSA-N
PubChem CID11933
ChEMBLCHEMBL1611235
EC No.210-323-0
DTXSIDDTXSID1020433
현지명3,3'-다이클로로벤지딘 이수화염화물

화학 및 물리적 성질

극성 표면적52
수소 결합 공여자 수4
수소 결합 수용자 수2
회전 가능 결합 수1
무거운 원자 수18
형식 전하0
복잡도213
물질 분류Nitrogen Compounds -> Benzidine and DerivativesCarcinogens
냄새mild odor
Color/FormWhite crystalswhite to light-gray powderNeedles
용해도less than 1 mg/mL at 70.7 °F (NTP, 1992)Readily sol in alcoholslightly soluble in water클로로포름(약간), DMSO(약간, 가열), 메탄올(약간, 가열)에 용해됨
DecompositionWhen heated to decomp it emits very toxic fumes of /hydrogen chloride & nitrogen oxides./
Physical Description3,3'-dichlorobenzidine dihydrochloride is a light tan powder. (NTP, 1992)CBIWet SolidWhite to light-gray solid[HSDB] Light tan solid[CAMEO]
녹는점132~137℃
용해도21.5&C에서 <0.1g/100mL
안정성안정적이지만 공기나 빛에 민감할 수 있습니다. 강한 산화제와 호환되지 않습니다.
InChIInChI=1S/C12H10Cl2N2.ClH/c13-9-5-7(1-3-11(9)15)8-2-4-12(16)10(14)6-8/h1-6H,15-16H21H
InChIKeyHXFNXEIKMAEASE-UHFFFAOYSA-N
SMILESClC1=C(C=CC(C2C=CC(N)=C(Cl)C=2)=C1)N.Cl
LogP(분배 계수)3.76 at 20℃
EPA3,3'-Dichlorobenzidine dihydrochloride (612-83-9)

화학적 성질

beige to tan powder

안전 및 규제

GHS 분류DangerH312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]P203, P261, P272, P273, P280, P302+P352, P317, P318, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 156 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
규제 정보Chemical: [1,1'-Biphenyl]-4,4'-diamine, 3,3'-dichloro-, dihydrochlorideHazard Traits - Carcinogenicity[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dichloro-, hydrochloride (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of [1,1'-Biphenyl]-4,4'-diamine, 3,3'-dichloro-, hydrochloride (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)REACH registered substance: 3,3'-dichlorobenzidine dihydrochloride (EC: 210-323-0)The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
기타 안전 정보IMAP assessments - [1,1'-Biphenyl]-4,4'-diamine, 3,3'-dichloro-, dihydrochloride: Environment tier I assessment
운송 라벨(DOT)Class 9
화재 위험Flash point data for this compound are not available but it is probably combustible. (NTP, 1992)
건강 유해성SYMPTOMS: This material may cause allergic skin reactions.
유해성 요약A mutagen and tumorigen[RTECS] Overexposure may cause skin sensitization, caustic burns, and hematuria[Merck Index] Emergency treatment: IrritantsSeverely irritating to eyes[HSDB] May cause skin sensitization[CAMEO] May cause skin sensitizationSeverely restricted for industrial use in the EU[eChemPortal: ESIS] May cause irritationMay cause skin sensitizationTargets the bladder and liver

용도

일반 설명

Light tan powder.

[MSDSonline] See 3,3'-Dichlorobenzidine.
반응성 그룹Salts, Acidic
Special ReportsNational Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. 3,3'-Dichlorobenzidine Dihydrochloride (612-83-9) is listed as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s063dicb.pdf]DHHS/ATSDRToxicological Profile for 3,3'-Dichlorobenzidine (1989) ATSDR/TP-89/09
OSHA StandardsThis section applies to any area in which the 13 carcinogens addressed by this section are manufactured, processed, repackaged, released, handled, or stored, but shall not apply to transshipment in sealed containers, except for the labeling requirements under paragraph (e)(2), (3) and (4) of this section. 3,3'-Dichlorobenzidine (and its salts) is one of the 13 carcinogens.
Reactivity Profile3,3'-DICHLOROBENZIDINE DIHYDROCHLORIDE reacts as a weak acid. May react vigorously with strong oxidizing agents. May generate flammable gases with strong reducing agents.
Air and Water ReactionsInsoluble in water.
NIOSH RecommendationsNIOSH considers 3,3'-dichlorobenzidine to be a potential occupational carcinogen. /3,3'-Dichlorobenzidine (and its salts)/NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /3,3'-Dichlorobenzidine (and its salts)/
소화Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
응급 처치EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
보관 조건Store in cool, dry place. Protection from light and air is recommended for long term storage. /Chemical Carcinogens/PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as /possible/ to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area.
정리 방법USE OF SODIUM HYPOCHLORITE BLEACH SOLUTION TO DECONTAMINATE 3,3'-DICHLOROBENZIDINE (DCB) WAS PARTIALLY EFFECTIVE. AN AQUEOUS SOLUTION OF 5% TETRAPOTASSIUM PYROPHOSPHATE AND 10% SODIUM ETHYL HEXYL SULFATE WHEN BLENDED IN A JET SPRAYER EFFECTIVELY REMOVED DCB FROM THE WORK AREA (90-99% REDUCTION). ONCE REMOVED FROM THE WORKSITE AND COLLECTED IN A CENTRAL LOCATION, IT WAS THEN DETERMINED THAT THE DIAZOTIZATION REACTION (THE ADDITION OF SO4, ICE AND NaNO3) OCCURRED TO ELIMINATE ANY DETECTABLE DCB FROM THE WASHINGS. /3,3'-DICHLOROBENZIDINE/PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes, or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly. ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated. ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators.
비화재 누출 대응SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
처리 방법At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.Incineration: 1500 °F, 0.5 sec for primary combustion2200 °F, 1.0 sec for secondary combustion. The formation of elemental chlorine can be prevented through injection of steam or methane into the combustion process. NOx may be abated through the use of thermal or catalytic devices.PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only.PRECAUTIONS FOR "CARCINOGENS": Total destruction ... by incineration may be only feasiable method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable. ... Most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory.For more Disposal Methods (Complete) data for 3,3'-DICHLOROBENZIDINE DIHYDROCHLORIDE (6 total), please visit the HSDB record page.
Preventive MeasuresRegulations in USA concerning 3,3'-dichlorobenzidine & its salts designate strict procedures to avoid worker contact: Mixtures containing 1.0% or more 3,3'-dichlorobenzidine & its salts must be maintained in isolated or closed systems, employees must observe special personal hygiene rules, & certain procedures must be followed for movement of the material & in case of accidental spills & emergencies ...Employees working with 3,3'-dichlorobenzidine (or its salts) within an isolated system, such as a "glove box" shall wash their hands and arms upon completion of the assigned task and before engaging in other activities not associated with the isolated system.On exit from a regulated area, employees should shower and change ... clothes, leaving protective clothing & equipment at the point of exit to be placed in ... /designated/ containers at the end of the work shift for decontamination or disposal.Storage or consumption of food, storage or use of containers of beverages, storage or application of cosmetics, smoking, storage of smoking materials, tobacco products or other products for chewing, and the chewing of such products are prohibited in regulated areas.For more Preventive Measures (Complete) data for 3,3'-DICHLOROBENZIDINE DIHYDROCHLORIDE (18 total), please visit the HSDB record page.
Isolation and EvacuationExcerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:
Threshold Limit Values (TLV)Exposure by all routes should be carefully controlled to levels as low as possible. Skin. /3,3'-Dichlorobenzidine/A3Confirmed animal carcinogen with unknown relevance to humans. /3,3'-Dichlorobenzidine/
Personal Protective Equipment (PPE)MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.Full body protective clothing and gloves should be employed in handling operations. Full face supplied air respirators of continuous flow or pressure demand type should also be used.PRECAUTIONS FOR "CARCINOGENS": ... dispensers of liq detergent ... Safety pipettes ... for all pipetting. ... In animal laboratory ... protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators ... when working with particulates or gases, & disposable plastic aprons ... gowns ... /should be/ of distinctive color ... .Wear appropriate personal protective clothing to prevent skin contact. /3,3'-Dichlorobenzidine (and its salts)/Wear appropriate eye protection to prevent eye contact. /3,3'-Dichlorobenzidine (and its salts)/For more Personal Protective Equipment (PPE) (Complete) data for 3,3'-DICHLOROBENZIDINE DIHYDROCHLORIDE (7 total), please visit the HSDB record page.
Immediately Dangerous to Life or Health (IDLH)NIOSH considers 3,3'-dichlorobenzidine to be a potential occupational carcinogen. /3,3'-Dichlorobenzidine (and its salts)/
유해 작용Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Medical SurveillancePreplacement and periodic exam should include history of exposure to other carcinogens, smoking, alcohol, medication, and family history. The skin, lung, kidney, bladder, and liver should be evaluatedsputum or urinary cytology may be helpful.PRECAUTIONS FOR "CARCINOGENS": ... In relation specifically to cancer hazards, there are at present no health monitoring methods that may ensure the early detection of preneoplastic lesions or lesions which may prelude them. Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning additional tests that might become useful or mandatory.
Human Toxicity Excerpts... PRONOUNCED STERNUTATORY /SNEEZING/ EFFECT.Gastrointestinal upset was one of the symptoms reported by employees who worked with 3,3'-dichlorobenzidine dihydrochloride (dihydro salt of 3,3'-dichlorobenzidine) ... . However, there is no conclusive evidence that the GI effects, or other symptoms reported by employees, resulted specifically from inhalation of 3,3'-dichlorobenzidine dihydrochloride.DERMAL EXPOSURE TO 3,3'-DICHLOROBENZIDINE BASE HAS CAUSED DERMATITIS IN DYE WORKERS. /3,3'-DICHLOROBENZIDINE/
Non-Human Toxicity Excerpts3,3'-DICHLOROBENZIDINE DIHYDROCHLORIDE AT 50 UG/PLATE & 100 UG/PLATE, WAS MODERATELY MUTAGENIC IN SALMONELLA TYPHIMURIUM STRAINS TA98 & TA100 WITHOUT THE MAMMALIAN ENZYME PREPARATIONHOWEVER, THE MUTAGENICITY WAS INCREASED MARKEDLY WHEN THE S-9 FRACTION WAS ADDED TO THE REACTION MIXTURES. MAMMALIAN ENZYME PREPARATIONS (S-9 FRACTIONS) WERE PREPARED FROM UNINDUCED ADULT MALE BALB/C MICE.The dihydrochloride salt was shown to be a severe eye irritant as opposed to the free basethe Draize test of rabbits produced erythema, chemoses, & corneal opacity with an average score of 84 out of 110 maximally attainable.ALL ANIMAL TESTS OF ACUTE & CHRONIC TOXICITY INDICATE BOTH BASE & /DIHYDROCHLORIDE/ SALT TO BE LOWTHE RAT ORAL LD50 WAS ABOUT 7 G/KGTHAT OF THE HYDROCHLORIDE SALT, 3.82 G/KGFOR THE RABBIT, BETWEEN 0.5 & 1 G/KG. GI CONGESTION & HEMORRHAGING WERE CHIEF AUTOPSY FINDINGS. NINE OF 14 RATS SURVIVED MORE THAN 288 DAYS OF INGESTING 700 MG/KG OF BASE IN OLIVE OIL, 5 DAYS/WK. LIVER DAMAGE & ONE TUMOR WERE ... /FOUND/.A GROUP OF 20 FEMALE SPRAGUE-DAWLEY RATS (40 DAYS OF AGE) WERE GIVEN 10 DOSES OF 3,3'-DICHLOROBENZIDINE DIHYDROCHLORIDE (PURITY & IMPURITIES UNSPECIFIED) EVERY THREE DAYS BY GASTRIC INTUBATION (TOTAL DOSE, 300 MG/RAT, WHICH WAS THE MAXIMUM TOLERATED DOSE). THE OBSERVATION PERIOD WAS NINE MONTHS, WHEN THE SURVIVING ANIMALS WERE KILLED. NO MAMMARY TUMORS WERE OBSERVED IN 15 RATS AUTOPSIED, WHILE 100% OF THE POSITIVE CONTROL GROUP (TREATED WITH 7,12-DIMETHYLBENZ(A)ANTHRACENE) & 3% OF ANIMALS TREATED WITH SESAME OIL ONLY HAD MAMMARY TUMORS ... .For more Non-Human Toxicity Excerpts (Complete) data for 3,3'-DICHLOROBENZIDINE DIHYDROCHLORIDE (7 total), please visit the HSDB record page.
Evidence for CarcinogenicityCLASSIFICATION: B2probable human carcinogen. BASIS FOR CLASSIFICATION: Based on statistically significantly increased tumor incidence in rats, mice and dogs. Additional support is provided by positive evidence of genotoxicity and structural relationship to the known human bladder carcinogen benzidine. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Sufficient. /3,3'-Dichlorobenzidine/Inadequate evidence of carcinogenicity in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans. /3,3'-Dichlorobenzidine/A3Confirmed animal carcinogen with unknown relevance to humans. /3,3'-Dichlorobenzidine/3,3'-Dichlorobenzidine Dihydrochloride: reasonably anticipated to be a human carcinogen.
Probable Routes of Human ExposureInhalation & probably percutaneous absorption.OCCUPATIONAL EXPOSURE TO 3,3'-DICHLOROBENZIDINE DIHYDROCHLORIDE HAS & PROBABLY STILL DOES OCCUR DURING ITS MANUFACTURE & CONVERSION TO DERIVED PIGMENTS. RUBBER WORKERS WERE FORMERLY & MAY STILL BE EXPOSED TO 3,3'-DICHLOROBENZIDINE USED FOR CURING POLYURETHANE ELASTOMERS.Processes in which dried dye is handled have the greatest potential for employee exposure during the manufacture or repackaging of benzidine-based dyes. ... During use of benzidine-based dyes, the greatest potential for exposure would be expected to be among dye-weighers who handle dry powders. /Benzidine-based dyes/
Non-Human Toxicity ValuesLD50 Rat (Sprague-Dawley) oral 3.82 g/kg
청정수법 요건Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Dichlorobenzidene/
수질 위해 등급(WGK)3
TSCA 등재 상태TSCA listed
RTECS 번호DD0550000
운송 번호(UN)UN 3077 9/PG 3
위험 문구(R)45-21-43-50/53
위험 표시T,N
안전 문구(S)53-45-60-61
기존화학 물질KE-10084
유해 물질 데이터612-83-9(Hazardous Substances Data)
함량 및 규제정보물질구분: 유독물질혼합물(제품)함량정보: 3,3'-디클로로벤지딘과 그 염류 및 그 중 하나를 1% 이상 함유한 혼합물
유해화학물질 필터링2005-1-547
중점관리물질 필터링별표1-89