N,N'-디아세틸벤지딘

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms. ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal. ... The plastic bag should be sealed immediately. ... The sealed bag should be labelled properly. ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated. ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... Summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": Total destruction ... by incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable. ... Most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": HEPA (high-efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for 4,4'-DIACETYLBENZIDINE (6 total), please visit the HSDB record page.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... Clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Operations connected with synth & purification ... should be carried out under well ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": Vertical laminar-flow biological safety cabinets may be used for containment of in vitro procedures ... provided that the exhaust air flow is sufficient to provide an inward air flow at the face opening of the cabinet, & contaminated air plenums that are under positive pressure are leak-tight. Horizontal laminar-flow hoods or safety cabinets, where filtered air is blown across the working area towards the operator, should never be used. ... Each cabinet or fume cupboard to be used ... should be tested before work is begun (eg, with fume bomb) & label fixed to it, giving date of test & avg air-flow measured. This test should be repeated periodically & after any structural changes. /Chemical Carcinogens/

For more Preventive Measures (Complete) data for 4,4'-DIACETYLBENZIDINE (9 total), please visit the HSDB record page.

Cough.

Redness.

PRECAUTIONS FOR "CARCINOGENS": ... In relation specifically to cancer hazards, there are at present no health monitoring methods that may ensure the early detection of preneoplastic lesions or lesions which may prelude them. Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning additional tests that might become useful or mandatory. /Chemical Carcinogens/

N,N'-Diacetylbenzidine

Group 2B: Possibly carcinogenic to humans

Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals

1987

1987

... 10 MALE & 10 FEMALE HOLTZMAN RATS ... RECEIVED DIET CONTAINING 429 MG/KG /OF DIET/ FOR 8 MO ... 8 MALES & 8 FEMALES DIED FROM ... GLOMERULONEPHRITIS. EXPT WAS TERMINATED @ 10 MO. 2 MALES DEVELOPED SQUAMOUS-CELL CARCINOMAS OF EAR-DUCT AFTER 5 & 7 MO. ... NO EAR-DUCT TUMORS OCCURRED IN 45 UNTREATED CONTROLS THAT SURVIVED UP TO 8 MO.

OF 17 MALE & 23 FEMALE RATS OF RAPPOLOV NURSERY ... GIVEN WEEKLY SUBCUTANEOUS INJECTIONS EACH OF 15 MG ... FOR 9 MO ... 13 ... WERE STILL ALIVE @ APPEARANCE OF FIRST TUMORS 2 MALE HAD HEPATOMAS, & 3 MALES & 1 FEMALE HAD CARCINOMAS OF BOTH LIVER & ZYMBAL GLAND. OF 25 CONTROLS INJECTED WITH SUNFLOWER OIL, 1 DEVELOPED SARCOMA ... IN LIVER ...

OF 6 FEMALE WISTAR RATS ... INJECTED ONCE SUBCUTANEOUS WITH 100 MG ... IN AQ SUSPENSION, 3 DEVELOPED TUMORS OF MAMMARY GLAND & 1 SKIN TUMOR ... NO TUMORS ... IN CONTROLS ...

AMONG 18 FEMALE RATS ... GIVEN 1 IP INJECTION OF 100 MG/ANIMAL ... 12 TUMORS OF EXTERNAL AUDITORY CANAL, 6 MAMMARY TUMORS (INCL ADENOCARCINOMAS) & 2 SKIN CARCINOMAS OCCURRED IN 11 ANIMALS. ... NO TUMORS WERE SEEN IN 30 CONTROL RATS ... .

For more Non-Human Toxicity Excerpts (Complete) data for 4,4'-DIACETYLBENZIDINE (19 total), please visit the HSDB record page.

Processes in which dried dye is handled have the greatest potential for employee exposure during the manufacture or repackaging of benzidine-based dyes. ... During use of benzidine-based dyes, the greatest potential for exposure would be expected to be among dye-weighers who handle dry powders. /Benzidine-based dyes/

Used as a research chemical and to prepare 3,3'-Dichlorobenzidine and 3,3'-Dinitrobenzidine; [HSDB]

USED TO PREPARE 3,3'-DICHLOROBENZIDINE AND 3,3'-DINITROBENZIDINE

RESEARCH CHEM (EG, CHEM INT FOR SUBSTITUTED BENZIDINES)

(1977) NOT PRODUCED COMMERCIALLY IN USA

(1979) NOT PRODUCED COMMERCIALLY IN USA

Acetamide, N,N'-[1,1'-biphenyl]-4,4'-diylbis-: ACTIVE

... HAS BEEN INVESTIGATED IN JAPAN FOR USE AS AN INTERMEDIATE IN MFR OF DIAMINOAZOBENZIDINE, RAW MATERIAL FOR AZO DYES; HOWEVER, THE PRODUCTION OF BENZIDINE & ITS DERIVATIVES HAS BEEN PROHIBITED IN JAPAN SINCE 1973.