Citraconic Anhydrides (HCID 12012)

개요

Methylmaleic anhydrides.

이름 및 식별자

우선 이름: Citraconic Anhydrides
IUPAC: 3-methylfuran-2,5-dione
현지명: 무수시트라콘산
영어명: Citraconic anhydride
분자식: C5H4O3
분자량: 112.08

이름 및 동의어

Citraconic AnhydridesAnhydride, CitraconicAnhydrides, CitraconicMethylmaleic AnhydridesAnhydrides, Methylmaleic2 Methylmaleic AnhydrideAnhydride, 2-MethylmaleicRefChem:388886Citraconic anhydride616-02-43-methylfuran-2,5-dione2-Methylmaleic anhydride

이름 더 보기

무수시트라콘산시트라콘무수물시트라콘무수물(CITRACONICANHYDRIDE)CTA3-methyl-furan-2,5-dionealpha-methylmaleicanhydridemethyl-maleicanhydrid3-methyl-5-furandioneIndobufen Impurity 53

2,5-Furandione, 3-methyl-METHYLMALEIC ANHYDRIDE3-Methylmaleic anhydrideCitraconic acid anhydrideMonomethylmaleic anhydrideMaleic anhydride, methyl-3-methyl-2,5-dihydrofuran-2,5-dione3-Methyl-2,5-furandione

데이터베이스 식별자

CAS: 616-02-4
PubChem CID: 12012
DTXSID: DTXSID8060660
ChEMBL: CHEMBL398893
UNII: 105NP7PMXX
EC Number: 210-459-0
Nikkaji: J55.438C、J679.309F

물성

구조 계산 물성

XLogP: 0.2
극성 표면적: 43.4 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 3
회전 가능 결합 수: 0
무거운 원자 수: 8
형식 전하: 0
복잡도: 178

실험 및 물리화학적 성질

PolymersPlastics & Rubber -> Acid Anhydrides, Cyclic

SpringerMaterials PropertiesBoiling point

Density1.2469 @ 16 °C/4 °C

Color/FormCOLORLESS LIQUID

SolubilitySOL IN ALCOHOL, ETHER, ACETONE

Boiling Point213-214 °C @ 760 MM HG

물리화학적 성질

녹는점: 6 · 6-10 °C (lit.)
끓는 점: 213 · 213-214 °C (lit.)
밀도: 1.247 g/mL · 1.247 g/mL at 25 °C (lit.)
증기 밀도: 4 · 4 (vs air)
증기압: 1.3 hPa · 1.3 hPa ( 47 °C)
굴절률: 20 · n20/D 1.471(lit.)
인화점: 215 °F · 215 °F
저장 조건: 2 · Inert atmosphere,2-8°C
용해도: 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태: 액체
색상: 투명하고 무색에서 아주 약간 노란색을 띤다.
수용성: 물에서 분해되다
BRN: 1835 · 1835
Dielectric constant: 40.3 · 40.3(20℃)
InChI: 1S/C5H4O3/c1-3-2-4(6)8-5(3)7/h2H,1H3
InChIKey: AYKYXWQEBUNJCN-UHFFFAOYSA-N
SMILES: CC1=CC(=O)OC1=O
LogP: -0.232 · -0.232 (est)
NIST: 2 · 2,5-Furandione, 3-methyl-(616-02-4)
EPA: 2 · 2,5-Furandione, 3-methyl- (616-02-4)

화학적 성질

clear colorless to very slightly yellow liquid

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H311 (23.9%): Toxic in contact with skin [Danger Acute toxicity, dermal]

P233, P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P333+P317, P342+P316, P361+P364, P362+P364, P363, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 222 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory InformationStatus: Active Update: 24-02-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/16743

Hazards SummaryAn irritant; [MSDSonline] See Maleic anhydride. See ACID ANHYDRIDES.

Hazard Classes and CategoriesAcute Tox. 3 (23.9%)

독성 정보

Non-Human Toxicity Excerpts · 2건

... CITRACONIC ACID ANHYDRIDE TESTED FULL STRENGTH BY DROP APPLICATION TO RABBITS EYES CAUSED SEVERE INJURY LIKE THAT CAUSED BY ACETIC ACID.

VARIOUS CHEMICAL GROUPS WERE EVALUATED FOR THEIR SKIN SENSITIZATION POTENTIAL IN THE GUINEA PIG. CITRACONIC ANHYDRIDE SENSITIZED 3 OF 10 GUINEA PIGS.

안전 데이터

wgk: 3
tsca: TSCA listed
rtecs: GE6825000
ridadr: UN 2810 6.1/PG 3
HS 번호: 29171990
risk_code: 23/24/25-36/37/38-42/43-34-24
hazard_code: T
safety_code: 26-36/37/39-45-28A-23-36/37
포장분류: III
위험 등급: 6.1
F 고인화성물질: 10-21
Hazard Classifications: Eye Dam. 1Resp. Sens. 1Skin Corr. 1BSkin Sens. 1
스토리지 클래스: 8A - Combustible corrosive hazardous materials
유해 물질 데이터: 616-02-4(Hazardous Substances Data)

화학 및 산업

용도 및 제조

Uses · 4건

Used as reagent for alkalies, alcohols, and amines; as monomer for specialty unsaturated polyester resins; [HSDB]

REAGENT FOR ALKALIES, ALCOHOLS, AND AMINES

MONOMER FOR SPECIALTY UNSATURATED POLYESTER RESINS

ANALYTICAL REAGENT FOR ALKALIES, ALCOHOLS & AMINES

U.S. Production(1979) AT LEAST 4.54X10+8 GRAMS

Methods of Manufacturing · 2건

PRODUCTION OF CITRACONIC ANHYDRIDE FROM ITACONIC ACID.

VACUUM PYROLYSIS OF CITRIC OR ITACONIC ACID

Formulations/PreparationsGRADES: REAGENT.

General Manufacturing Information2,5-Furandione, 3-methyl-: ACTIVE

응용 분야 · 2건

용도Citraconic anhydride is used as a monomer for specialty unsaturated polyester resins. It is used to prepare bicyclic pyrrolidines, maleimides and co- and terpolymers. It is also used for the protection of N-terminal amino acids. Further, it is involved in the preparation of clothing ping acid and its amide. In addition to this, it is selectively used for the isolation of histidyl peptides.

일반 설명Citraconic anhydride is a reversible blocking agent for the lysine side chain. A major advantage of the citraconic anhydride reaction is that the blocking group can be readily removed without causing protein denaturation[1].

상·하류 제품 정보

상류 원료

하류 제품

Dimethyl methylsuccinate 시트라콘산 3,6-Dichloro-4-methylpyridazine Mono-methyl succinate 숙신산무수물 5-하이드록시-3-메틸-2(5H)-푸라논 메틸(3-),-2-퓨라논 4-메틸-2(5H)-푸라논 2-(3-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid 2,5-푸란디온,3-(broMo메틸)

공급사50 곳

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

常州佳德医药科技有限公司18006124028

韶关高科祥高新材料有限公司15089879907

Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

연결된 노트

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무수시트라콘산

기본 정보

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