Ethyl Glycolate (HCID 12184)

개요

Based on the available information included in this report, the CIR Expert Panel concludes that Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations less than or equal to 10%, at final formulation pH greater than or equal to 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations less than or equal to 30%, at final formulation pH greater than or equal to 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection...Ethyl Glycolate...

이름 및 식별자

우선 이름: Ethyl Glycolate
IUPAC: ethyl 2-hydroxyacetate
영어명: Ethyl glycolate
분자식: C4H8O3
분자량: 104.1

이름 및 동의어

Ethyl glycolate623-50-7Ethyl hydroxyacetateHydroxyacetic acid ethyl esterGLYCOLIC ACID, ETHYL ESTEREthyl glycollateNSC 8835Acetic acid, 2-hydroxy-, ethyl esterC306E91WFKAI3-03541NSC-8835EINECS 210-798-4

이름 더 보기

HOCH2COOC2H5EthylGlycolate>Ethyl glycolate,95%Ethyl glycolate 98%Ethyl glycolate ,98%ETHYL2-HYDROXYACETATE

BRN 17437664-03-00-00580 (Beilstein Handbook Reference)RefChem:596202Acetic acid, hydroxy, ethyl esterAcetic acid, 2hydroxy, ethyl esterethyl 2-hydroxyacetateAcetic acid, hydroxy-, ethyl esterMFCD00021970

데이터베이스 식별자

CAS: 623-50-7
PubChem CID: 12184
DTXSID: DTXSID5060772
UNII: C306E91WFK
EC Number: 210-798-4
Nikkaji: J53.999F

물성

구조 계산 물성

XLogP: -0.2
극성 표면적: 46.5 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 3
회전 가능 결합 수: 3
무거운 원자 수: 7
형식 전하: 0
복잡도: 60

실험 및 물리화학적 성질

Chemical ClassesOther Classes -> Esters, Other

CosmeticsCosmetic ingredients (Ethyl Glycolate) -> CIR (Cosmetic Ingredient Review)

SpringerMaterials PropertiesSchoenflies notation

Physical DescriptionClear colorless liquid; [Acros Organics MSDS]

물리화학적 성질

녹는점: 300 °C · >300 °C
끓는 점: 158 · 158-159 °C (lit.)
밀도: 1.1 g/mL · 1.1 g/mL at 25 °C (lit.)
굴절률: 20 · n20/D 1.419(lit.)
인화점: 143 °F · 143 °F
저장 조건: Sealed in dry,Room Temperature
용해도: 에 용해됨클로로포름, 메탄올 (약간 용해됨)
산도 계수 (pKa): 13.14 · 13.14±0.10(Predicted)
물리적 상태: 액체
색상: 무색의
냄새: Peculiar ethereal, weedy-winey odour, often classified as "Spearmint-like".
수용성: 50 C · 물, 알코올, 아세톤, 아세테이트에 매우 잘 녹고 에틸 에테르에 약간 녹고 탄화수소 용매에 거의 녹지 않으며 중합은 50C 이상에서 발생합니다.
InChI: 1S/C4H8O3/c1-2-7-4(6)3-5/h5H,2-3H2,1H3
InChIKey: ZANNOFHADGWOLI-UHFFFAOYSA-N
SMILES: CCOC(=O)CO
NIST: Acetic acid, hydroxy-, ethyl ester(623-50-7)
EPA: Acetic acid, hydroxy-, ethyl ester (623-50-7)

화학적 성질

clear colorless liquid

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 45 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazards SummaryA mild eye irritant in guinea pigs; Causes general anesthesia, muscle weakness, and cyanosis in intraperitoneal lethal-dose studies of rats (LDLo = 1,500 mg/kg); [RTECS] An irritant; [Acros Organics MSDS]

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

독성 정보

Adverse EffectsNeurotoxin - Acute solvent syndrome

Toxicity Summary · 2건

Based on the available information included in this report, the CIR Expert Panel concludes that Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations less than or equal to 10%, at final formulation pH greater than or equal to 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations less than or equal to 30%, at final formulation pH greater than or equal to 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection...Ethyl Glycolate...

Safe for use in cosmetics, with qualifications

안전 데이터

wgk: 3
tsca: TSCA listed
rtecs: MC5410000
ridadr: 1993
HS 번호: 29181990
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36/37/39-37/39
포장분류: III
위험 등급: 3.2
기존화학 물질: KE-20319
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
스토리지 클래스: 10 - Combustible liquids

화학 및 산업

용도 및 제조

UsesCIR ingredient: Ethyl Glycolate

General Manufacturing InformationAcetic acid, 2-hydroxy-, ethyl ester: ACTIVE

응용 분야 · 2건

용도Ethyl glycolate, is an important building block for the preparation of agrochemicals and medicinal compounds. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dye stuff. It is also used in synthetic chemistry, discovery process and R&D. It also can be used as solvents.

일반 설명Ethyl glycollate is an ester. Microwave spectra of ethyl glycollate and its deuterated species has been reported.

제조 방법

생산 방법The corresponding acid occurs in unripe Grapes. Ethyl glycolate is produced from Ethylene glycol by oxidation to Glycoiiic acid, followed by esterification.

상·하류 제품 정보

상류 원료

하류 제품

Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)Fluroxypyr 글리세롤폼알 Ethyl nitroacetate (2,4-dinitro-phenoxy)-acetic acid ethyl ester 3H-1,2,4-Triazole-3-thione, 2,4-dihydro-5-(hydroxymethyl)-4-methyl- (9CI)2-트리플루오로메탄술포닐옥시아세트산에틸에스테르 에틸3-aMino-6-broMo-1-벤조푸란-2-카르복실레이트 N-사이클로헥실글리신 아세트산,(2,3-디클로로페녹시)-,에틸에스테르 ethyl 2-((4-methoxybenzyl)oxy)acetate

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

韶远科技（上海）有限公司021-50795510 4000665055 · [email protected]

연결된 노트

불러오는 중…

Ethyl Glycolate

기본 정보

개요