기본 정보
- CAS
71138-97-1- 표준 SMILES
CC(=O)O.CC(O)CO.CO.O=C(O)CCC(=O)O- InChIKey
ZUAAPNNKRHMPKG-UHFFFAOYSA-N- 분자식
- C10H22O9
- 평균 분자량
- 286.28 g/mol
개요
structure given in first source
이름 및 식별자
- 우선 이름
- Hypromellose Acetate Succinate
- IUPAC
- acetic acid;butanedioic acid;methanol;propane-1,2-diol
- 현지명
- 하이드록시프로필메틸셀룰로오스아세테이트/석시네이트
- 영어명
- Hydroxypropyl methyl cellulose acetate succinate
- 분자식
- C10H22O9
- 분자량
- 0
이름 및 동의어
Hypromellose acetate succinate71138-97-1UNII-24P2YXD2PWUNII-36BGF0E889hydroxypropylmethylcellulose acetate succinateUNII-6N003M473WHypromellose acetate succinate [NF]RefChem:147500HpmcasHypromellose ASLF; Affinisol HPMCAS 912GHydroxypropyl methylcellulose acetate succinateacetic acid;butanedioic acid;methanol;propane-1,2-diol
이름 더 보기
하이드록시프로필메틸셀룰로오스아세테이트/석시네이트하이드록시프로필메틸셀룰로오스아세테이트숙시네이트acetic acid, methanol, propane-1,2-diol, succinic acidHPMCAS AS-MFacetic acid, methanolacidhydroxypropylmethylacidesterHypromellose Acetate Succinate(HPMCAS)Hypromellose Acetate Succinate (100 mg)Hypromellose Acetate Succinate (1335279)Acetate hydroxypropyl methylcellulose succinate
SCHEMBL15366423C10H22O9FH167007acetic acid;methanol;propane-1,2-diol;succinic acidCellulose,2-hydroxypropylmethylehter,acetatehydrogenbutanedioateCellulose, 2-hydroxypropyl methyl ether, acetate hydrogen butanedioate
물성
구조 계산 물성
- 극성 표면적
- 173 Ų
- 수소 결합 공여자 수
- 6
- 수소 결합 수용자 수
- 9
- 회전 가능 결합 수
- 4
- 무거운 원자 수
- 19
- 형식 전하
- 0
- 복잡도
- 146
물리화학적 성질
- 녹는점
- 203 °C · >203°C (dec.)
- 저장 조건
- -20 °C · Hygroscopic, -20°C Freezer, Under inert atmosphere
- 용해도
- Practically insoluble in ethanol (95%), hexane, unbuffered water, and xylene. On the addition of acetone, or a mixture of ethanol (95%) and dichloromethane (1 : 1), a clear or turbid viscous solution is produced. Hypromellose acetate succinate also forms a clear or turbid solution in buffers of pH greater than 4.5 with the rank order of solubility for the various grades increasing with the ratio of acetyl over succinoyl substitution. The exact pH value at which the polymer starts to swell and dissolve depends on the buffer type and ionic strength, although the rank order for the different grades is independent of the buffer used. No solvent has been found to completely dissolve hypromellose acetate succinate polymer; the resulting clear or turbid solutions significantly scatter light in both static and dynamic light scattering experiments, indicating that the polymer may exist as colloids or aggregates. The data is collated from the Shin-Etsu Chemical Co. Ltd and the research work of the authors (R Chen, BC Hancock, and RM Shanker).
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
- 안정성
- 흡습성
- 주요 응용
- 제약
- 화장품 원료 기능
- 필름 형성제
- LogP
- -0.591 · -0.591 (est)
화학적 성질
soluble in organic solvents, including acetone, methanol, aqueous ethanol
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (25 of 25) of all reports.
Not Classified
Aggregated GHS information provided per 25 reports by companies from 1 notifications to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesNot Classified
안전 데이터
- wgk
- WGK 3
- HS 번호
- 3912390000
- 기존화학 물질
- 2010-3-4896
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
용도Hypromellose Acetate Succinate HPMCAS;is a pharmaceutical compound comprising enzalutamide.
제조 방법
생산 방법Hypromellose acetate succinate is produced by the esterification of hypromellose with acetic anhydride and succinic anhydride, in a reaction medium of a carboxylic acid, such as acetic acid, and using an alkali carboxylate, such as sodium acetate, as catalyst. The fibrous reaction product is precipitated out by adding a large volume of water to the reaction medium. Purification is achieved by thorough washing with water. The granular grade of hypromellose acetate succinate that is so obtained can be pulverized to a fine powder if required.
상·하류 제품 정보
상류 원료
공급사98 곳
国药集团化学试剂有限公司86-21-63210123 · [email protected]
江西益众化工有限公司15307925109 15350027073 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
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