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기본 정보
- CAS
117690-79-6- 표준 SMILES
CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1- InChIKey
WCGXJPFHTHQNJL-UHFFFAOYSA-N- 분자식
- C19H28N4O3
- 평균 분자량
- 360.458 g/mol
- 단동위원소 질량
- 360.21614076
이름 및 식별자
- 우선 이름
- LY 255283
- IUPAC
- 1-(5-Ethyl-2-hydroxy-4-{[6-methyl-6-(2H-tetrazol-5-yl)heptyl]oxy}phenyl)ethan-1-one
- 영어명
- 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
- 분자식
- C19H28N4O3
- 분자량
- 360.45
이름 및 동의어
LY 255283CGS 23356LY255283 ，S2959LY255283, 10 mM in DMSOLY255283, BLT2 receptor antagonist5'-Ethyl-2'-hydroxy-4'-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOLE-5-YL)HEPTYL]OXY]PHENYL]-ETHANONEparcnchyma,LTB4,Leukotriene Receptor,inhibit,BLT2,LY255283,lung,Inhibitor,LY-255283
데이터베이스 식별자
- CAS
117690-79-6- PubChem CID
- 122023
- DTXSID
DTXSID30151872- ChEMBL
CHEMBL15766- ChEBI
CHEBI:93616- UNII
- H037W1I5AL
- Nikkaji
- J302.384B
물성
물리화학적 성질
- 녹는점
- 160 · 160-162 °C
- 끓는 점
- 573.4 · 573.4±60.0 °C(Predicted)
- 밀도
- 1.157 · 1.157±0.06 g/cm3(Predicted)
- 저장 조건
- 4 °C · Store at +4°C
- 용해도
- 20 mg/mL · DMSO: >20mg/mL
- 산도 계수 (pKa)
- 5.11 · 5.11±0.10(Predicted)
- 물리적 상태
- 가루
- 색상
- 황백색에서 밝은 노란색까지
- InChI
- 1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23)
- InChIKey
- WCGXJPFHTHQNJL-UHFFFAOYSA-N
- SMILES
- CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c2nnn[nH]2
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 2
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
개요Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years. The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100 nM. LY255283 exhibits IC50 values of ~950 nM and >10 μM at human recombinant BLT2 and BLT1 receptors, respectively. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 μM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260 nM.
용도LY-255283 is a selective, competitive BLT2 receptor antagonist used in the treatment of chronic myeloid leukemia.
공급사22 곳
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]
Nantong HI-FUTURE Biology Co., Ltd.+86-18051384581 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
上海瀚香生物科技有限公司177-54423994 17754423994 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
广州爱纯医药科技有限公司020-39119399 18927568969 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
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