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기본 정보
- CAS
114289-47-3- 표준 SMILES
CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC- InChIKey
WAFNZAURAWBNDZ-UHFFFAOYSA-N- 분자식
- C23H39NO4
- 평균 분자량
- 393.568 g/mol
- 단동위원소 질량
- 393.28790873
이름 및 식별자
- 우선 이름
- 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
- IUPAC
- 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
- 현지명
- 2,2-디메틸-N-(2,4,6-트리메톡시페닐)도데칸아미드
- 영어명
- 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
- 분자식
- C23H39NO4
- 분자량
- 393.56
이름 및 동의어
2,2-디메틸-N-(2,4,6-트리메톡시페닐)도데칸아미드CI 976PD 128042CI-976 (PD 128042)PD 128042, 10 mM in DMSON-(2,4,6-Trimethoxyphenyl)-2,2-dimethyldodecanamide2,2-DIMETHYL-N-(2,4,6-TRIMETHOXYPHENYL)DODECANAMIDE2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)-dodecanamidDodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-inhibit,oral,PD128042,PD 128042,CI-976,Diacylglycerol acyltransferase,PD-128042,Acyltransferase,transferase,secretory,LPAT,acyl-CoA:cholesterol acyltransferase,mono- acylglycerol acyltransferase,endocytic membrane trafficking pathway,ACAT,CI976,Diglyceride acyltransferase,Inhibitor
데이터베이스 식별자
- CAS
114289-47-3- PubChem CID
- 122327
- DTXSID
DTXSID00150690- ChEMBL
CHEMBL22373- ChEBI
CHEBI:95040- UNII
- 8653IQ20EA
- EC Number
- 635-231-1
- Nikkaji
- J367.021J
물성
물리화학적 성질
- 저장 조건
- 2 · 2-8°C
- 용해도
- 10 mg/mL · DMSO: >10mg/mL
- 물리적 상태
- 고체
- 색상
- White to off-white
- InChI
- InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
- InChIKey
- WAFNZAURAWBNDZ-UHFFFAOYSA-N
- SMILES
- C(NC1=C(OC)C=C(OC)C=C1OC)(=O)C(C)(C)CCCCCCCCCC
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- Hazard Classifications
- Aquatic Chronic 4
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
개요Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol O-acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption. CI-976 is a potent, selective inhibitor of ACAT-1 (IC50 = 73 nM). It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia. CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits.
용도CI-976 (2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide) is a selective inhibitor of Acyl-coenzyme A: cholesterol Acyltransferase 1 (ACAT-1), a sterol O-acetyltransferase that catalyzes information of fatty acid-cholesterol esters. Orally bioavailable and decreses plasma total cholesterol
공급사46 곳
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武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
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United Life Science
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