Snc 80

HCID 123924
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기본 정보

CAS
156727-74-1
표준 SMILES
C=CCN1C[C@H](C)N([C@H](c2ccc(C(=O)N(CC)CC)cc2)c2cccc(OC)c2)C[C@H]1C
InChIKey
KQWVAUSXZDRQPZ-UMTXDNHDSA-N
분자식
C28H39N3O2
평균 분자량
449.6 g/mol
단동위원소 질량
449.3042275

개요

4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane.

이름 및 식별자

우선 이름
Snc 80
IUPAC
4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
영어명
SNC 80
분자식
C28H39N3O2
분자량
449.63

이름 및 동의어

Snc 80156727-74-1Snc-80SNC804-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamideL842QB22SW4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamideNIH-108154-((R)-((2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl)-(3-methoxyphenyl)methyl)-N,N-diethylbenzamideRefChem:931887DTXSID60456624-[(R)-[(2S,5R)-2,5-Dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide
이름 더 보기
NIH 10815SNC80, delta opioid receptor agonist(+)-4-[(Ar)-alpha-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAM(+)-4-[(aR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide(+)-4-[(AR)-ALPHA-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE
UNII-L842QB22SWCHEMBL134704-[(R)-[(2S,5R)-2,5-DIMETHYL-4-(PROP-2-EN-1-YL)PIPERAZIN-1-YL](3-METHOXYPHENYL)METHYL]-N,N-DIETHYLBENZAMIDENSC7074844-((2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide (2S-(1(S*),2alpha,5beta))-NCGC00024777-02Benzamide, 4-((2,5-dimethyl-4-(2-propenyl)-1-piperazinyl)(3-methoxyphenyl)methyl)-N,N-diethyl-, (2S-(1(S*),2alpha,5bet))-Benzamide, 4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethyl-

데이터베이스 식별자

CAS
156727-74-1
PubChem CID
123924
DTXSID
DTXSID6045662
ChEMBL
CHEMBL13470
ChEBI
CHEBI:109556
UNII
L842QB22SW
Nikkaji
J601.902A

물성

구조 계산 물성

XLogP
4.9
극성 표면적
36 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
4
회전 가능 결합 수
9
무거운 원자 수
33

물리화학적 성질

녹는점
122 · 122-123°C
끓는 점
564.8 · 564.8±50.0 °C(Predicted)
밀도
1.04 · 1.040
저장 조건
Store at RT
용해도
DMSO: 용해될 수 있다
물리적 상태
고체

화학적 성질

Crystalline Solid

안전 및 규제

안전 데이터

wgk
3
스토리지 클래스
11 - Combustible Solids

화학 및 산업

응용 분야 · 2건

개요SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor. It effectively activates μ/δ receptor heteromers (EC50 = 52.8 nM) but not κ/δ or μ/κ heteromers. SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.

용도A highly selective and potent non-peptide -agonist, 2000-fold selective over u-receptors

상·하류 제품 정보

공급사38 곳

武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]

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