1,2,3,5-Tetrachlorobenzene

log Kow= 4.66

4.68

less than 0.1 mg/mL at 67.1 °F (NTP, 1992)

SOL IN HOT WATER, ETHER, BENZENE; SLIGHTLY SOL IN ALCOHOL; VERY SOL IN CARBON DISULFIDE, PETROLEUM ETHER

In water, 5.1 mg/l at 25 °C.

greater than 235 °F (NTP, 1992)

Flash point > 113 °C

475 °F at 760 mmHg (NTP, 1992)

246 °C

122 to 126 °F (NTP, 1992)

51 °C

1 mmHg at 136.8 °F ; 5 mmHg at 192 °F; 760 mmHg at 475 °F (NTP, 1992)

0.07 [mmHg]

0.073 mm Hg at 25 °C

1,2,3,5-tetrachlorobenzene appears as white crystals or off-white solid. (NTP, 1992)

Colorless solid; [HSDB] White or off-white solid; [CAMEO]

This chemical does not meet GHS hazard criteria for 2.3% (1 of 44) of reports.

Warning

H302 (97.7%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 44 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

A decrease in the number of fetuses was the only significant effect observed at the highest dose level (200 mg/kg) in a study with pregnant rats (no teratogenic effects or histopathological changes in mothers or fetuses); Caused histological changes to liver and kidney in 13 week feeding study with rats; Effects in two month feeding study include altered liver function, prothrombin index, blood cholesterol, and adrenal hypertrophy; [HSDB] May cause irritation to skin, eyes, nose, throat, and respiratory tract; Long term exposure may cause kidney and liver injury; [CHEMINFO] Effects to the liver in short term gavage studies with rats include porphyria, enlargement, and focal necrosis; Histopathological changes observed to kidney and liver in 90 day feeding study with rats; [INCHEM]

USEPA; Ambient Water Quality Criteria Doc: Chlorinated Benzenes (1980) EPA 440/5-80-028

USEPA; Health Assessment Document: Chlorinated Benzenes (1985) EPA-600/8-84-015

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1,2,3,5-Tetrachlorobenzene is included on this list.

Simple aromatic halogenated organic compounds, such as 1,2,3,5-TETRACHLOROBENZENE, are very unreactive. Halogenated organics generally become less reactive as more of their hydrogen atoms are replaced with halogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. This chemical may react with oxidizers. (NTP, 1992).

Acute Tox. 4 (97.7%)

Hazardous to the aquatic environment (Acute) - Category 1

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

1,2,3,5-Tetrachlorobenzene has been detected in 13 of 108 samples of human adipose tissue at a mean concn of 30 ng/g(1). Combined trichlorobenzene and tetrachlorobenzene isomers were detected in human adipose tissue in Slovenia at a concn of 60 ng/g and in human hair samples at 40 ng/g(2). 1,2,3,5-Tetrachlorobenzene was identified, not quantified, in the adipose tissue of non-occupationally exposed individuals in Germany(3). 1,2,3,5-Tetrachlorobenzene was detected at an avg concn in human blood of 5.1 ng/g and adipose tissue at 0.41 ng/g(4).

Since TeCB's can increase cytochrome p450 levels, ... it appears to induce metabolic enzymes. /This/ induction of microsomal enzyme activity has been shown to enhance the metabolism of a wide variety of drugs, pesticides and other xenobiotics. Exposure to TeCB could therefore result in decreased pharmacologic and/or toxicologic activity of numerous compounds. /In the event/ that chemical agents are metabolized to more active or toxic reactive intermediates ... exposure to TeCB would result in enhanced activity and/or toxicity of these agents. /Tetrachlorobenzenes/

LC50 Bluegill sunfish 57.8 mg/l/24 hr; 11.5 mg/l/48hr; 6.42 mg/l/96hr.

LC50 Sheepshead Minnow > 7.5 mg/l/24 hr; 5.59 mg/l/48hr; 3.67 mg/l/96hr.

TERRESTRIAL FATE: Based on a recommended classification scheme(1), and log Koc values in the range of 3.2-4.2(2,3), 1,2,3,5-tetrachlorobenzene is expected to have low mobility in soil(SRC). Volatilization of 1,2,3,5-tetrachlorobenzene is expected from moist soil surfaces given its Henry's Law constant of 1.6X10-3 atm-cu m/mole at 25 °C(4), but adsorption may attenuate this process(SRC). Volatilization of 1,2,3,5-tetrachlorobenzene from dry soil surfaces is not expected(SRC) based on a vapor pressure of 0.07 mm Hg at 25 °C(4). A half-life of 45 days in sewage sludge amended soil suggests that biodegradation of 1,2,3,5-tetrachlorobenzene will be slow(5).

AQUATIC FATE: Based on a recommended classification scheme(1), and a log Koc value of 3.9(2) measured in sediment, 1,2,3,5-tetrachlorobenzene is expected to adsorb to suspended solids and sediment in water(SRC). 1,2,3,5-Tetrachlorobenzene is expected to volatilize from water surfaces(3,SRC) given its Henry's Law constant of 1.6X10-3 atm-cu m/mole at 25 °C(4), but adsorption may attenuate this process(SRC). Estimated volatilization half-lives for a model river and model lake are 5 and 150 hours, respectively when neglecting adsorption(3,SRC). The volatilization half-life from a model pond is 36 days when adsorption is considered(5). According to a classification scheme(6), BCF values in the range of 1,300 to 3,600 measured in fish(7-9), suggest that bioconcentration in aquatic organisms is high(SRC). A half-life of 19 days in an acclimated anaerobic sediment slurry suggests that biodegradation of 1,2,3,5-tetrachlorobenzene will be slow(10). When irradiated with light greater than 285 nm, this compound was degraded 66 percent in 40 hrs in a water solution(11), suggesting that photolysis in surface waters may be important(SRC).

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1,2,3,5-Tetrachlorobenzene is included on this list.

1,2,3,5-TETRACHLOROBENZENE WAS IDENTIFIED AS METABOLITE OF PENTACHLOROPHENOL.

CANTHATCH WHEAT SEEDS WERE TREATED WITH LINDANE-(14)C (480 PPM) & PLANTED, TOTAL (14)C RESIDUES WERE DETERMINED IN 19-DAY-OLD SEEDLINGS, 1,2,3,5-TETRACHLOROBENZENE WAS IDENTIFIED IN ROOT SAMPLES.

YIELDS 2,3,4,6-TETRACHLOROPHENOL IN RABBIT. /FROM TABLE/

Lindane administered to hen pheasants resulted in tetrachlorobenzene being identified ... as part of the array of metabolites found in eggs and chicks as well as in the body tissues of hens. /Tetrachlorobenzenes/

For more Metabolism/Metabolites (Complete) data for 1,2,3,5-TETRACHLOROBENZENE (7 total), please visit the HSDB record page.

Three tetrachlorobenzene (TCB) congeners (1,2,3,4- 1,2,3,5- and 1,2,4,5-Tetrachlorobenzene were administered daily by gavage to pregnant Sprague-Dawley rats at levels of 50, 100, or 200 mg/kg from day 6-15 of gestation. Residues of all three congeners were found in maternal and fetal tissues but generally the amounts of the 1,2,4,5- isomer were about 100 times higher than the other two.

Used as an intermediate for herbicides and defoliants; as an insecticide; as an impregnant for moisture resistance; for electrical insulation; for temporary protection in packing; Not commercially produced in the US; [HSDB] Used for electrical insulating fluids in transformers; A break-down product of the pesticide Lindane; [CHEMINFO]

Farming (Pesticides) [Category: Industry]

RESEARCH CHEMICAL

INTERMEDIATE FOR HERBICIDES & DEFOLIANTS; INSECTICIDE; IMPREGNANT FOR MOISTURE RESISTANCE; ELECTRICAL INSULATION

TEMPORARY PROTECTION IN PACKING

(1977) NOT PRODUCED COMMERCIALLY IN US

(1979) NOT PRODUCED COMMERCIALLY IN US

PRODUCED AS BY-PRODUCT IN MFR OF 1,2,4,5-TETRACHLOROBENZENE BY CHLORINATION OF 1,2,4-TRICHLOROBENZENE OVER ALUMINUM AMALGAM; CHLORINATION OF 1,3,5-TRICHLOROBENZENE OVER ALUMINUM AMALGAM

Obtained by chlorination of 1,3,5-trichlorobenzene