2-Cyanoethyl tetraisopropylphosphorodiamidite (HCID 128153)

이름 및 식별자

우선 이름: 2-Cyanoethyl tetraisopropylphosphorodiamidite
IUPAC: 3-bis[di(propan-2-yl)amino]phosphanyloxypropanenitrile
영어명: 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite
분자식: C15H32N3OP
분자량: 301.41

이름 및 동의어

102691-36-1Cetipd2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamiditePhosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester2-CYANOETHYL TETRAISOPROPYLPHOSPHORODIAMIDITEDTXSID8075176RefChem:862807DTXCID50327333-((Bis(diisopropylamino)phosphino)oxy)propanenitrileBis(diisopropylamino)(2-cyanoethoxy)phosphine2-CYANOETHYL N,N,N',N'-TETRAISOPROPYLPHOSPHORODIAMIDITEP-Reagent

이름 더 보기

3-Bis(diisopropylamino)phosphanyloxypropanenitrileTHERAPEUTIC GRADE PHOS REAGENTTETRAISOPROPYLPHOSPHORODIAMIDITE94.0%(GC&

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphordiamiditeMFCD00012213C15H32N3OPPhosphorodiamidous acid, N,N,N',N'-tetrakis(1-methylethyl)-, 2-cyanoethyl ester2-Cyanoethyl N,N,N',N'-Tetraisopropylphosphoramidite3-bis[di(propan-2-yl)amino]phosphanyloxypropanenitrile3-(bis(diisopropylamino)phosphinooxy)propanenitrile3-((Bis(diisopropylamino)phosphino)oxy)-propanenitrile

데이터베이스 식별자

CAS: 102691-36-1
PubChem CID: 128153
DTXSID: DTXSID8075176
UNII: 8P2H5F3TEA
EC Number: 600-337-9
Nikkaji: J738.473D

물성

구조 계산 물성

XLogP: 3.3
극성 표면적: 39.5 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 4
회전 가능 결합 수: 9
무거운 원자 수: 20
형식 전하: 0
복잡도: 273

물리화학적 성질

끓는 점: 100 °C0.5 · 100 °C0.5 mm Hg(lit.)
밀도: 0.949 g/mL · 0.949 g/mL at 25 °C(lit.)
굴절률: 20 · n20/D 1.470(lit.)
인화점: 141 °F · 141 °F
저장 조건: -20 °C · -20°C
용해도: Acetonitrile (Slightly), Benzene, Chloroform (Sparingly), Methanol (Slightly)
물리적 상태: 액체
산도 계수 (pKa): 6.78 · 6.78±0.70(Predicted)
색상: 무색의
BRN: 3590103 · 3590103
안정성: 가열되면 폭발함
InChI: 1S/C15H32N3OP/c1-12(2)17(13(3)4)20(19-11-9-10-16)18(14(5)6)15(7)8/h12-15H,9,11H2,1-8H3
InChIKey: RKVHNYJPIXOHRW-UHFFFAOYSA-N
SMILES: CC(C)N(C(C)C)P(OCCC#N)N(C(C)C)C(C)C
LogP: 4.04 at · 4.04 at 20℃
EPA: Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester (102691-36-1)

화학적 성질

Clear to Cloudy Colourless Liquid

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H226 (97.2%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P280, P284, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P321, P330, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P370+P378, P403, P403+P235, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 179 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 2건

Status: Active Update: 01-08-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25176

Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesFlam. Liq. 3 (97.2%)

안전 데이터

wgk: 3
ridadr: UN 1993 3/PG 3
HS 번호: 29299000
risk_code: 5-36/37/38-42/43-36/38
hazard_code: Xi,Xn
safety_code: 3-26-36-24/25-23-45-36/37
포장분류: I
위험 등급: 8
F 고인화성물질: 10-21-34
위험 참고 사항: Irritant/May Explode on Heating
Hazard Classifications: Acute Tox. 4 OralAquatic Chronic 3Flam. Liq. 3Skin Sens. 1B
스토리지 클래스: 3 - Flammable liquids

화학 및 산업

응용 분야 · 2건

개요2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite is a colorless viscous liquid, which is soluble in most organic solvents. It is a widely used phosphitylating reagent for the preparation of various phosphorylated biomolecules, such as nucleoside carbohydrate conjugates, phospholipids and glycopeptides. In particular, this reagent is highly effective for automated solid-phase DNA/RNA oligonucleotide synthesis. It has shown great utility in the coupling of nucleobases or carbohydrates via their phosphotriesters in the presence of activators such as 1H-tetrazole, in moderate yields under mild conditions.This compound is cheaper and more stable than 2-cyanoethyl N,N-diisopropylchlorophosphorodiamidite (the other commonly used phosphinylating reagent)[1].

용도Reagent for synthesizing phosphitylated nucleotides.1

상·하류 제품 정보

상류 원료

하류 제품

세프티부텐 anionic starch DMT-DCYTIDINE(N6-BENZOYL)시아노에틸인산염)DMT-dG(dmf) Phosphoramidite Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-(1,7-octadiyn-1-yl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite], (S)- (9CI)DMT-dA(bz) Phosphoramidite 3'-DA CEP 5'-DMT-3'-O-TBDMS-N1-Me-Pseudouricdine-CE-Phosphoramidite 4-티오두CEP (2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-5-(3-(2,2,2-TRIFLUOROACETAMIDO)PROP-1-YNYL)-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE DMT-2'O-Methyl-rU Phosphoramidite

공급사50 곳

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

T&W GROUP021-61551611 13296011611 · [email protected]

北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]

연결된 노트

불러오는 중…

2-Cyanoethyl tetraisopropylphosphorodiamidite

기본 정보