Dimethyltin dichloride
753-73-1[CH3][Sn]([CH3])([Cl])[Cl]PKKGKUDPKRTKLJ-UHFFFAOYSA-LDimethyltin dichloride is an organotin compound. Tin is a chemical element with the symbol Sn and atomic number 50. It is a natural component of the earth's crust and is obtained chiefly from the mineral cassiterite, where it occurs as tin dioxide. (L307, L309)
753-73-1DTXSID5027304Wet Solid; Liquid
Produced as a solid or aqueous solution; [ECHA - Proposal for Harmonised Classification and Labelling] White crystalline solid; [Alfa Aesar MSDS]
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
Danger
H301: Toxic if swallowed [Danger Acute toxicity, oral]
P203, P260, P262, P264, P270, P271, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P318, P319, P320, P321, P330, P361+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P203, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P320, P321, P330, P361+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Chemical: Stannane, dichlorodimethyl-
Stannane, dichlorodimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Stannane, dichlorodimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Dimethyltin dichloride (EC: 212-039-2)
Dimethyltin dichloride: Does not have an individual approval but may be used under an appropriate group standard
Produced as a mixture with monomethyltin trichloride (CAS# 993-16-8); Teratogenicity observed in rats administered 20 mg/kg on days 7-17 of gestation; [Shepard's Catalog of Teratogenic Agents] Corrosive to rabbit skin; The nervous system is the target of toxicity in 90-day oral studies of rats, with neuropathological lesions observed in one study at doses as low as 25 ppm (1.6/2.2 mg/kg/day); One oral study of rats produced serious teratogenic effects not considered as related to maternal toxicity; Another study of rats demonstrated no teratogenicity; Possible developmental neurotoxicity observed in other studies of rats; [ECHA - Proposal for Harmonised Classification and Labelling] Reacts with water; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion, inhalation, and skin absorption; [Alfa Aesar MSDS] See Trimethyltin chloride and Di-n-butyltin dichloride. See Tin, organic compounds.
Though tin metal is very poorly absorbed, tin compounds may be absorbed via oral, inhalation, or dermal routes, with organotin compounds being much more readily absorbed than inorganic tin compounds. Tin may enter the bloodstream and bind to hemoglobin, where it is distributed and accumulates mainly in the kidney, liver, lung, and bone. Organotin compounds may undergo dealkylation, hydroxylation, dearylation, and oxidation catalyzed by cytochrome P-450 enzymes in the liver. The alkyl products of dealkylation are conjugated with glutathione and further metabolized to mercapturic acid derivatives. Tin and its metabolites are excreted mainly in the urine and feces. (L308)
Used for stabilizing PVC potable water piping, making abrasion resistant glass containers, and as a catalyst for curing electrocoated paints; [Shepard's Catalog of Teratogenic Agents] Used to make other organotin compounds and for glass coating; [OECD: SIDS Dossier]
Painting (Pigments, Binders, and Biocides) [Category: Paint]
All Other Basic Organic Chemical Manufacturing
Stannane, dichlorodimethyl-: ACTIVE
용도Used as a pharmaceutical intermediate. It is employed as a coating, plastic and rubber auxilliary agent. Used as methyl Tin stabilizer intermediates, catalysts for esterification reaction, raw material for glass coating.
불러오는 중…
white crystalline powder
Acute Tox. 3 (100%)
Acute toxicity (ingestion) - category 3
Repr. 2
Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local release of pro-inflammatory cytokines, tumor necrosis factor-_, and/or interleukins. They may also induce apoptosis by direct action on neuronal cells. Organotin compounds stimulate the neuronal release of and/or decrease of neuronal cell uptake of neurotransmitters in brain tissue, including aspartate, GABA, glutamate, norepinephrine, and serotonin. This may be either a contributing factor to or result of the neuronal cell loss. The immunotoxic effects of organotins are characterized by thymic atrophy caused by the suppression of proliferation of immature thymocytes and apoptosis of mature thymocytes. Organotin compounds are believed to exert these effects by suppressing DNA and protein synthesis, inducing the expression of genes involved in apoptosis (such as nur77), and disrupting the regulation of intracellular calcium levels, giving rise to the uncontrolled production of reactive oxygen species, release of cytochrome c to the cytosol, and the proteolytic and nucleolytic cascade of apoptosis. The suppression of proliferation of immature thymocytes further results in the suppression of T-cell-mediated immune responses. Organotins are also endocrine disruptors and are believed to contribute to obesity by inappropriate receptor activation, leading to adipocyte differentiation. Inorganic tin triggers eryptosis, contributing to tin-induced anemia. (L308, A182, A184)