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디메틸틴 디 클로라이드

Dimethyltin dichloride

HCID 12955
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인쇄 미리보기
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
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기본 정보

CAS
753-73-1
표준 SMILES
[CH3][Sn]([CH3])([Cl])[Cl]
InChIKey
PKKGKUDPKRTKLJ-UHFFFAOYSA-L
분자식
C2H6Cl2Sn
평균 분자량
219.68 g/mol
단동위원소 질량
219.886858

개요

Dimethyltin dichloride is an organotin compound. Tin is a chemical element with the symbol Sn and atomic number 50. It is a natural component of the earth's crust and is obtained chiefly from the mineral cassiterite, where it occurs as tin dioxide. (L307, L309)

이름 및 식별자

우선 이름
Dimethyltin dichloride
IUPAC
dichloro(dimethyl)stannane
현지명
디메틸틴 디 클로라이드
영어명
Dimethyltin dichloride
분자식
C2H6Cl2Sn
분자량
219.68

이름 및 동의어

Dimethyltin dichloride753-73-1DichlorodimethyltinDichlorodimethylstannaneDimethyldichlorotinSTANNANE, DICHLORODIMETHYL-DimethyltindichlorideDimethyldichlorostannaneCotin 210Dichlorid dimethylcinicityDimethylzinndichlorideDTXSID5027304
이름 더 보기
디메틸틴디클로라이드이염소화주석이메틸(CH3)2SnCl2DMTC50%SKL1117tin dichLTwo MethyltinDiMethyltin-di
DMTC7K42FNK7A0NSC-55159DTXCID907304RefChem:588622212-039-2dichloro(dimethyl)stannaneTin, dimethyl-, dichloride

데이터베이스 식별자

CAS
753-73-1
PubChem CID
12955
DTXSID
DTXSID5027304
UNII
7K42FNK7A0
EC Number
212-039-2

물성

구조 계산 물성

극성 표면적
0 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
0
회전 가능 결합 수
0
무거운 원자 수
5
형식 전하
0
복잡도
30.6

실험 및 물리화학적 성질

Chemical ClassesMetals -> Tin Compounds, Organic
Vapor Pressure0.2 [mmHg]
Physical Description · 2건

Wet Solid; Liquid

Produced as a solid or aqueous solution; [ECHA - Proposal for Harmonised Classification and Labelling] White crystalline solid; [Alfa Aesar MSDS]

물리화학적 성질

녹는점
101 · 101-106 °C (lit.)
끓는 점
188 · 188-190°C
밀도
1 · 1,397 g/cm3
증기압
4 Pa · 4Pa at 20℃
인화점
185 · 185-190°C
저장 조건
2 · 2-8°C
용해도
0.1 g/mL, · 메탄올: 0.1 g/mL, 투명
물리적 상태
수정 같은
색상
하얀색
Specific Gravity
1.397 · 1.397
수용성
물에 약간 용해됩니다(20g/L(20°C)). 다른 용매에 대한 용해도(메탄올 중 0.1g/ml).
BRN
3660508 · 3660508
안정성
흡습성, 수분 민감성

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 6건

Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]

P203, P260, P262, P264, P270, P271, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P318, P319, P320, P321, P330, P361+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P203, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P320, P321, P330, P361+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

유해성 정보

Regulatory Information · 4건

Chemical: Stannane, dichlorodimethyl-

Stannane, dichlorodimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Stannane, dichlorodimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Dimethyltin dichloride (EC: 212-039-2)

Dimethyltin dichloride: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Stannane, dichlorodimethyl-: Human health tier II assessment
Hazards Summary · 1건

Produced as a mixture with monomethyltin trichloride (CAS# 993-16-8); Teratogenicity observed in rats administered 20 mg/kg on days 7-17 of gestation; [Shepard's Catalog of Teratogenic Agents] Corrosive to rabbit skin; The nervous system is the target of toxicity in 90-day oral studies of rats, with neuropathological lesions observed in one study at doses as low as 25 ppm (1.6/2.2 mg/kg/day); One oral study of rats produced serious teratogenic effects not considered as related to maternal toxicity; Another study of rats demonstrated no teratogenicity; Possible developmental neurotoxicity observed in other studies of rats; [ECHA - Proposal for Harmonised Classification and Labelling] Reacts with water; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion, inhalation, and skin absorption; [Alfa Aesar MSDS] See Trimethyltin chloride and Di-n-butyltin dichloride. See Tin, organic compounds.

화학 및 산업

약리 정보

Metabolism/Metabolites · 1건

Though tin metal is very poorly absorbed, tin compounds may be absorbed via oral, inhalation, or dermal routes, with organotin compounds being much more readily absorbed than inorganic tin compounds. Tin may enter the bloodstream and bind to hemoglobin, where it is distributed and accumulates mainly in the kidney, liver, lung, and bone. Organotin compounds may undergo dealkylation, hydroxylation, dearylation, and oxidation catalyzed by cytochrome P-450 enzymes in the liver. The alkyl products of dealkylation are conjugated with glutathione and further metabolized to mercapturic acid derivatives. Tin and its metabolites are excreted mainly in the urine and feces. (L308)

용도 및 제조

Uses · 2건

Used for stabilizing PVC potable water piping, making abrasion resistant glass containers, and as a catalyst for curing electrocoated paints; [Shepard's Catalog of Teratogenic Agents] Used to make other organotin compounds and for glass coating; [OECD: SIDS Dossier]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

U.S. Production2023: 1,000,000 - <8,500,000 lb
Industry UsesIntermediate
General Manufacturing Information · 2건

All Other Basic Organic Chemical Manufacturing

Stannane, dichlorodimethyl-: ACTIVE

응용 분야

용도Used as a pharmaceutical intermediate. It is employed as a coating, plastic and rubber auxilliary agent. Used as methyl Tin stabilizer intermediates, catalysts for esterification reaction, raw material for glass coating.

상·하류 제품 정보

하류 제품

관련 반응

14건
반응 기록 만들기
HRID 86193 반응식
HRID 86193반응물로Training data from https://doi.org/10.1039/C8SC04228D (2/10)
HRID 323912 반응식
HRID 323912반응물로uspto-grants-2001_04
HRID 461427 반응식
HRID 461427반응물로uspto-grants-1977_12
HRID 613794 반응식
HRID 613794반응물로uspto-grants-1999_12
HRID 908518 반응식
HRID 908518반응물로uspto-grants-2011_09
HRID 1086911 반응식
HRID 1086911반응물로uspto-grants-1991_07
HRID 1130162 반응식
HRID 1130162반응물로Training data from https://doi.org/10.1039/C8SC04228D (7/10)
HRID 1440432 반응식
HRID 1440432반응물로uspto-grants-1996_03
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화합물 노트

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더보기
새 노트새 반응견적 요청하기
InChI
1S/2CH3.2ClH.Sn/h2*1H3;2*1H;/q;;;;+2/p-2
InChIKey
PKKGKUDPKRTKLJ-UHFFFAOYSA-L
SMILES
C[Sn](C)(Cl)Cl
LogP
-2.18 at · -2.18 at 22℃
EPA
Stannane, dichlorodimethyl- (753-73-1)

화학적 성질

white crystalline powder

Hazard Classes and Categories · 3건

Acute Tox. 3 (100%)

Acute toxicity (ingestion) - category 3

Repr. 2

안전 및 보호

Exposure Control and Personal Protection0.02 [mg/m3], as Sn[German Research Foundation (DFG)]
Threshold Limit Values (TLV)0.2 [mg/m3], as Sn
Permissible Exposure Limit (PEL)0.1 [mg/m3], as Sn
Immediately Dangerous to Life or Health (IDLH)25.0 [mg/m3], as Sn

독성 정보

Health EffectsBreathing or swallowing, or skin contact with organotins, can interfere with the way the brain and nervous system work, causing death in severe cases. Organic tin compounds may also damage the immune and reproductive system. (L307, L308)
Adverse EffectsNeurotoxin - Other CNS neurotoxin
Exposure RoutesOral (L308) ; inhalation (L308) ; dermal (L308)
Toxicity Summary · 1건

Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local release of pro-inflammatory cytokines, tumor necrosis factor-_, and/or interleukins. They may also induce apoptosis by direct action on neuronal cells. Organotin compounds stimulate the neuronal release of and/or decrease of neuronal cell uptake of neurotransmitters in brain tissue, including aspartate, GABA, glutamate, norepinephrine, and serotonin. This may be either a contributing factor to or result of the neuronal cell loss. The immunotoxic effects of organotins are characterized by thymic atrophy caused by the suppression of proliferation of immature thymocytes and apoptosis of mature thymocytes. Organotin compounds are believed to exert these effects by suppressing DNA and protein synthesis, inducing the expression of genes involved in apoptosis (such as nur77), and disrupting the regulation of intracellular calcium levels, giving rise to the uncontrolled production of reactive oxygen species, release of cytochrome c to the cytosol, and the proteolytic and nucleolytic cascade of apoptosis. The suppression of proliferation of immature thymocytes further results in the suppression of T-cell-mediated immune responses. Organotins are also endocrine disruptors and are believed to contribute to obesity by inappropriate receptor activation, leading to adipocyte differentiation. Inorganic tin triggers eryptosis, contributing to tin-induced anemia. (L308, A182, A184)

Signs and SymptomsInorganic or organic tin compounds placed on the skin or in the eyes can produce skin and eye irritation. (L308)
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Toxicity DataLC50 (rat) = 115 mg/m3/4hr

안전 데이터

wgk
3
tsca
TSCA listed
rtecs
WH7245000
ridadr
UN 2923 8/PG 2
HS 번호
29319090
risk_code
23/24/25-36/37/38-34
hazard_code
T
safety_code
26-36/37/39-45
포장분류
II
위험 등급
6.1
기존화학 물질
KE-10117
Hazard Classifications
Acute Tox. 2 InhalationAcute Tox. 3 DermalAcute Tox. 3 OralAquatic Chronic 3Eye Dam. 1Repr. 2Skin Corr. 1BSTOT RE 1
스토리지 클래스
6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
Trimethyltin chloride
디메틸주석딜라우레이트