2,2,6,6-Tetramethylpiperidine (HCID 13035)

이름 및 식별자

우선 이름: 2,2,6,6-Tetramethylpiperidine
IUPAC: 2,2,6,6-tetramethylpiperidine
현지명: 2,2,6,6-테트라메틸피페리딘
영어명: 2,2,6,6-Tetramethylpiperidine
분자식: C9H19N
분자량: 141.25

이름 및 동의어

2,2,6,6-Tetramethylpiperidine768-66-1NorpempidinePIPERIDINE, 2,2,6,6-TETRAMETHYL-2,2,6,6-TETRAMETHYL PIPERIDINEMFCD00005985HTMP2,2,6,6-tetramethyl-piperidine44N9S1YCFMNSC-1028382,2,6,6-TetramethylpeperidineEINECS 212-199-3

이름 더 보기

2,2,6,6-테트라메틸피페리딘TETRAMETHYLPIPERIDINE2,2,6,6-TetramethyL2,2,6,6-Teteamethyl-piperidine6-TetraMethylpiperidine2,2,6,6-Tetramethylpiperidine(Tmp)2,2,62,2,6,6-TetramethylpMedetomidine Impurity 100

UNII-44N9S1YCFMNSC 1028382,2,6,6 Tetramethyl piperidineNSC102838SCHEMBL151002,6,6-TetramethylpiperidineSCHEMBL146951SCHEMBL210605

데이터베이스 식별자

CAS: 768-66-1
PubChem CID: 13035
DTXSID: DTXSID0061113
ChEMBL: CHEMBL2448812
UNII: 44N9S1YCFM
EC Number: 212-199-3
Nikkaji: J1.732I

물성

구조 계산 물성

XLogP: 2.1
극성 표면적: 12 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 1
회전 가능 결합 수: 0
무거운 원자 수: 10
형식 전하: 0
복잡도: 111

실험 및 물리화학적 성질

Chemical ClassesNitrogen Compounds -> Amines, Cyclic

SpringerMaterials PropertiesChemical shift

Vapor Pressure0.98 [mmHg]

Physical DescriptionLight yellow liquid; [Sigma-Aldrich MSDS]

Dissociation Constants11.1

물리화학적 성질

녹는점: -59 °C · -59°C
끓는 점: 152 °C · 152 °C (lit.)
밀도: 0.837 g/mL · 0.837 g/mL at 25 °C (lit.)
증기압: 14 hPa · 14 hPa (39 °C)
굴절률: 20 · n20/D 1.445(lit.)
인화점: 76 °F · 76 °F
저장 조건: 30 °C · Store below +30°C.
용해도: 물과 섞임
산도 계수 (pKa): 11.07 · 11.07(at 25℃)
물리적 상태: 액체
Specific Gravity: 0.837 · 0.837
색상: 무색~황색으로 투명함
수용성: 혼용 가능
BRN: 103296 · 103296
InChI: 1S/C9H19N/c1-8(2)6-5-7-9(3,4)10-8/h10H,5-7H2,1-4H3
InChIKey: RKMGAJGJIURJSJ-UHFFFAOYSA-N
SMILES: CC1(C)CCCC(C)(C)N1
NIST: 2 · Piperidine, 2,2,6,6-tetramethyl-(768-66-1)
EPA: 2 · Piperidine, 2,2,6,6-tetramethyl- (768-66-1)

화학적 성질

clear colorless to light yellow-green liquid

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H226 (97.1%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 102 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 3건

Chemical: Piperidine, 2,2,6,6-tetramethyl-

Status: Active Update: 11-05-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/19475

2,2,6,6-Tetramethylpiperidine: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 1건

Rats demonstrated effects possibly indicative of neurotoxicity in all test groups of acute inhalation study and high dose group (500 mg/kg) of acute oral study; [EPA - TSCATS] A skin and strong eye irritant; Toxic by ingestion; [Sigma-Aldrich MSDS] See Piperidine.

Hazard Classes and CategoriesFlam. Liq. 3 (97.1%)

독성 정보

Adverse EffectsNeurotoxin - Other CNS neurotoxin

Toxicity DataLC50 (rat) = 4,550 mg/m3/4hr

안전 데이터

wgk: 2
tsca: TSCA listed
rtecs: TN4220000
ridadr: UN 1992 3/PG 3
독성: LD50 orally in Rabbit: 500 mg/kg
HS 번호: 29333999
risk_code: 10-22-36/37/38
hazard_code: Xn,F,C
safety_code: 26-37/39-16
포장분류: III
위험 등급: 3
자연 발화 온도: 290 °C
Hazard Classifications: Acute Tox. 4 OralEye Dam. 1Flam. Liq. 3Met. Corr. 1Skin Corr. 1ASTOT SE 3
스토리지 클래스: 3 - Flammable liquids
함량 및 규제정보: 물질구분: 유독물질; 혼합물(제품)함량정보: 2,2,6,6-테트라메틸피페리딘 및 이를 25% 이상 함유한 혼합물
유해화학물질 필터링: 2017-1-797(신규화학물질)

화학 및 산업

용도 및 제조

General Manufacturing InformationPiperidine, 2,2,6,6-tetramethyl-: ACTIVE

응용 분야

용도권장되는 용도 실험실용 화학물질.

용도2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.

제조 방법

Many routes for the synthesis of TMP have been reported. One method starts with a conjugate addition reaction of ammonia to phorone. The intermediate triacetone amine is then reduced in a Wolff-Kishner reaction.

상·하류 제품 정보

하류 제품

2-Methoxy-6-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile 5-Fluoro-2-picolinic acid 5-Formyl-2,4-dimethoxypyrimidine 3-Bromo-2-((cyclopropylamino)methyl)benzaldehyde (E)-5-(2-Carboxyvinyl)-2,4-dimethoxypyrimidine 3-CYANOPYRIDIN-4-일보론산 5-(Trifluoromethyl)-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile 2-Chloro-6-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile 2-CYANOPYRIDIN-3-일보론산 3-Methoxy-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile 2-(3-Methoxyphenyl)cyclohexanone 4-(Trifluoromethyl)-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile

공급사50 곳

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

INTATRADE GmbH+49 3493/605464 · [email protected]

爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

연결된 노트

불러오는 중…

2,2,6,6-테트라메틸피페리딘

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