메틸(3-)-3-부텐-2-온

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

INHALATION: remove victim from exposure; give artificial respiration if needed; call physician.

General First Aid:

...MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL, WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED...

/Store/...at subzero temp to prevent polymerization.

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible); polymerization hazard]:

Immediate precautionary measure

Goggles or face shield; rubber gloves. (USCG, 1999)

PROTECTIVE EQUIPMENT, INCLUDING OCCLUSIVE EYE PROTECTION TO PREVENT EYE DAMAGE BY VAPORS SHOULD BE...USED.

...rubber gloves /inhibited/

...A DEFINITE SKIN IRRITANT. ...DEVELOPMENT OF BLISTERING & PAIN MAY NOT OCCUR IMMEDIATELY UPON CONTACT. SEVERAL MINUTES MAY ELAPSE BEFORE SUCH MANIFESTATIONS ARISE.

...MODERATE TO HIGH DEGREE OF TOXICITY BY SINGLE ORAL EXPOSURE. EYE CONTACT...MAY RESULT IN SEVERE DAMAGE RESULTING...IN...PERMANENT IMPAIRMENT OF VISION... VAPORS ARE ALSO HIGHLY TOXIC AS WELL AS IRRITATING TO THE RESPIRATORY PASSAGES.

METHYL ISOPROPENYL KETONE IS HIGHLY TOXIC BY THE ORAL, PERCUTANEOUS, & RESPIRATORY ROUTES. TOPICAL EXPOSURE TO THE SKIN MAY BE MODERATELY IRRITATING WHILE TOPICAL OR VAPOR EXPOSURE TO THE EYE MAY BE SEVERELY IRRITATING.

When tested by application to rabbit eyes, methyl isopropenyl ketone was found to cause severe irritation & damage. ...moderate irritant to rabbit skin particularly when applied under a wrap. ... Rats survived a 90-min exposure to nominal vapor concn of 524 ppm, but exhibited...irritation of ocular & nasal tissues. At a nominal vapor of 1455 ppm for 30 min.../irritation/ & deaths occurred in minutes. Animals dying during these exposures were cyanotic & died in convulsions.

7-hr exposures of rats, guinea pigs, & rabbits for 20 exposures in 28 days at...30 ppm resulted in...ocular & nasal irritation in all species, death & weight loss in rats, & decreased growth in guinea pigs. In rats, the lungs were severely affected &...changes were found in the kidneys & spleen. Leukocytosis was also observed. Organs of other species were not significantly affected. One hundred 7-hr exposures of 15 ppm...to rats, guinea pigs, & rabbits over 140-day period produced ocular & nasal irritation in all animals. Also, mortality, leukocytosis, & slight renal damage characterized by increased kidney weight & slight tubular damage occurred in the rats.

Short-term exposures...ranging from 0.291 to 14.5 ppm have been reported. There was a questionable odor but no irritation at 0.291 ppm. At 0.77 ppm, there was an immediate definite odor & the vapors were evident to the eyes after a few min. At 1.45 & 2.91 ppm, eye irritation was apparent. At 14.5 ppm, there was an immediate strong odor with eye irritation...after 2 min. Ocular irritation rapidly increased in severity with time. ... Industrial exposures are likely to be by inhalation, skin & eye contact. Its strong irritating & lacrimatory properties may not prevent toxicity because these effects are often not immediately sensed.