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Cosmetic ingredients (Calcium Lactate) -> CIR (Cosmetic Ingredient Review)

Buffering

Soluble in water and practically insoluble in ethanol

Almost odorless, slightly efflorescent granules or powder; slowly sol in cold water; quickly sol in water; almost insol in alcohol; becomes anhydrous @ 120 °C; pH: 6-8 /Pentahydrate/

Sol in water

Dry Powder

Almost odourless, white crystalline powder or granules

White solid; Soluble in water; [HSDB] White crystalline powder; Soluble in water; [MSDSonline]

This chemical does not meet GHS hazard criteria for 3.7% (7 of 191) of reports.

Warning

H319 (96.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)

Aggregated GHS information provided per 191 reports by companies from 3 notifications to the ECHA C&L Inventory.

Warning

Chemical: Propanoic acid, 2-hydroxy-, calcium salt (2:1)

Regulation (EC) No 1831/2003 (amended)

Propanoic acid, 2-hydroxy-, calcium salt (2:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Propanoic acid, 2-hydroxy-, calcium salt (2:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Cease Manufacture Update: 05-04-2013 https://echa.europa.eu/registration-dossier/-/registered-dossier/11981

Propanoic acid, 2-hydroxy-, calcium salt (2:1): Does not have an individual approval but may be used under an appropriate group standard

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Calcium lactate used as a general purpose food additive is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Eye Irrit. 2 (96.3%)

Eye Irrit. 2 (100%)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Based on the available information included in this report, the CIR Expert Panel concludes that Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations less than or equal to 10%, at final formulation pH greater than or equal to 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations less than or equal to 30%, at final formulation pH greater than or equal to 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection...Calcium Lactate...

Safe for use in cosmetics, with qualifications

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Calcium lactate used as a general purpose food additive is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

A - Alimentary tract and metabolism

QA - Alimentary tract and metabolism

In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways. Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis.

In hepatic gluconeogenesis, lactic acid is converted to glucose. Lactic acid may be further catabolyzed in the lactic acid cycle.

RUMINAL INGESTA FROM COWS FED 2.5 L GRAIN-ALFALFA HAY MIXT PROVIDING 545 G OF SODIUM LACTATE & CALCIUM LACTATE DAILY INCUBATED WITH SODIUM LACTATE OR 17 POLY LACTIC ACID. ACETATE WAS PRIMARY END PRODUCT BUT OXIDN OF LACTATE CAUSED SYNTH OF BUTYRATE FROM ACETATE.

In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins. The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport.

Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours.

The majority of calcium absorbed (99%) is stored in the skeleton and teeth for structural integrity.

No pharmacokinetic data available.

CIR ingredient: Calcium Lactate

Used as a food preservative and calcium supplement; Also used in dentifrices, respirator filters, buffering agents, food firming agents, and gelling salts for low methoxypectin; [HSDB]

FOOD ADDITIVE

Preservative in foods and beverages; in dentifrices; calcium replenisher.

IN RESPIRATOR FILTER FOR ADSORPTION OF VAPORS

MEDICATION

(1972) 6.11X10+8 GRAMS (LACTIC ACID)

(1973) 6.25X10+8 GRAMS (LACTIC ACID)

2023: 50,000 - <250,000 lb

(1972) 8.63X10+8 GRAMS (ALL LACTIC ACID SALTS)

(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS

FERMENTATION OF CARBOHYDRATES TO LACTIC ACID, WITH PH CONTROLLED BY CALCIUM CARBONATE; REACTION OF LACTIC ACID WITH CALCIUM CARBONATE OR CALCIUM HYDROXIDE

... Commercially by neutralization of lactic acid, from fermentation of dextrose, molasses, starch, sugar or whey, with calcium carbonate.

CALCIUM LACTATE USP; POWDER USP, TABLETS USP, 325 MG (42.25 MG CALCIUM), & 650 MG (84.5 MG CALCIUM)

Commercial prepn usually contains about 25% water, and on the anhydrous basis it is at least 98% pure.

GRADES: NF; FCC.

Food additives

Food Additives -> ACIDITY_REGULATOR; FLOUR_TREATMENT_AGENT; YEAST_FOOD -> JECFA Functional Classes

Cosmetics -> Buffering

Agriculture, Forestry, Fishing and Hunting

Propanoic acid, 2-hydroxy-, calcium salt (2:1): ACTIVE

Commercial baking powder contains 2.5% calcium lactate.