Pagoclone
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기본 정보
- CAS
133737-32-3- 표준 SMILES
CC(C)CCC(=O)CC1c2ccccc2C(=O)N1c1ccc2ccc(Cl)nc2n1- InChIKey
HIUPRQPBWVEQJJ-UHFFFAOYSA-N- 분자식
- C23H22ClN3O2
- 평균 분자량
- 407.9 g/mol
- 단동위원소 질량
- 407.1400546
개요
Pagoclone is an anxiolytic drug from the cyclopyrrolone family, which is related to other more well known drugs such as the sleeping medication zopiclone. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures.
이름 및 식별자
- 우선 이름
- Pagoclone
- IUPAC
- 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-3H-isoindol-1-one
- 영어명
- Pagoclone
- 분자식
- C23H22ClN3O2
- 분자량
- 407.89
이름 및 동의어
Pagoclone133737-32-3IP 456PagoclonaRP 62955RP-62955IP-456CI-10432-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-2,3-dihydro-1H-isoindol-1-one38VAG2SA33DTXSID40869830IP456
이름 더 보기
Pagoclone Labeled d42-(7-Chloro-2-naphthyridin-1,8-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone1H-Isoindol-1-one, 2-(7-chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-
RP62955pagoclonumRefChem:858293DTXCID908177402-(7-chloro-1.8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-1H-isoindol-1-one133737-48-1rac-Pagoclone2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one
데이터베이스 식별자
- CAS
133737-32-3、133737-48-1- PubChem CID
- 131664
- DTXSID
DTXSID40869830
물성
구조 계산 물성보충 중
- XLogP
- 4.6
- 극성 표면적
- 63.2 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 29
- 형식 전하
- 0
- 복잡도
- 613
실험 및 물리화학적 성질
LogP4.8
물리화학적 성질
- 녹는점
- 173 · 173-179°C
- 저장 조건
- -20 °C · -20°C Freezer
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 옅은 주황색에서 옅은 빨간색까지
화학 및 산업
약리 정보
Pharmacodynamics
Pagoclone was originally developed as an anti-anxiety drug, but never commercialised. It is a partial agonist acting at GABAA receptors in the brain. In contrast to zopiclone, pagoclone produces anxiolytic effects with little or no sedative or amnestic actions at low doses.
Mechanism of Action
Pagoclone is a subtype-selective drug which binds primarily to the alpha2/alpha3 subtypes of the GABAA receptor which are responsible for the anti-anxiety effects of these kind of drugs, but has relatively little efficacy at the alpha1 subtype which produces the sedative and memory loss effects.
응용 분야
용도Pagoclone is a partial GABAA agonist, used to reduce panic attacks and appear to decrease symptoms of generalized anxiety.
상·하류 제품 정보
상류 원료
관련 반응
10건
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