Tripotassium citrate

HCID 13344CAS 7778-49-6

기본 정보

표준 SMILES
O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[K+].[K+].[K+]
InChIKey
QEEAPRPFLLJWCF-UHFFFAOYSA-K
분자식
C6H5K3O7
평균 분자량
306.39 g/mol
단동위원소 질량
305.8946469

이름 및 식별자

우선 이름
Tripotassium citrate
IUPAC
tripotassium;2-hydroxypropane-1,2,3-tricarboxylate

이름 및 동의어

TRIPOTASSIUM CITRATE866-84-2KaliksirPotassium citrate anhydrousLitocitPorekalKajosUrocit KSeltz-KK citrateCitric acid, tripotassium saltPotassium tribasic citrate
이름 더 보기
ACALKA86R1NVR0HW1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium saltDTXSID8027325RefChem:933490Anhydrous, Potassium CitrateDTXCID907325212-755-5

데이터베이스 식별자

CAS
7778-49-6、866-84-2
PubChem CID
13344
DTXSID
DTXSID8027325
ChEMBL
CHEMBL1200458
ChEBI
CHEBI:64733
UNII
86R1NVR0HW
EC Number
212-755-5、231-905-0
Nikkaji
J7.148J

물성

구조 계산 물성

극성 표면적
141 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
7
회전 가능 결합 수
2
무거운 원자 수
16

실험 및 물리화학적 성질

pH · 2건

Between 7,5 and 9,0 (5 % aqueous solution)

THE AQ SOLN IS ALKALINE TO LITMUS; PH ABOUT 8.5

OdorODORLESS
TasteHAS COOLING, SALINE TASTE
Density1.98 @25 °C
Color/Form · 2건

WHITE CRYSTALS, GRANULES, OR POWDER

TRANSPARENT CRYSTALS

Solubility · 3건

1 G DISSOLVES IN 0.65 ML WATER

1 G DISSOLVES VERY SLOWLY IN 2.5 ML GLYCEROL

ALMOST INSOL IN ALCOHOL

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 96.3% (572 of 594) of all reports.

Not Classified;Reported as not meeting GHS hazard criteria by 572 of 594 companies (only 3.7% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 594 reports by companies from 4 notifications to the ECHA C&L Inventory.;Reported as not meeting GHS hazard criteria per 572 of 594 reports by companies.;There are 2 notifications provided by 22 of 594 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

This chemical does not meet GHS hazard criteria for 100% (14 of 14) of all reports.

Not Classified;Reported as not meeting GHS hazard criteria by 14 of 14 companies. For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 14 reports by companies from 2 notifications to the ECHA C&L Inventory.;Reported as not meeting GHS hazard criteria per 14 of 14 reports by companies.;There are 0 notifications provided by 0 of 14 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 5건

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 19-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14309

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Human health tier I assessment
Hazards SummaryPotassium salts by mouth in doses less than 2 mEq/kg are usually not toxic in patients with normal renal function; [HSDB] May cause irritation; [MSDSonline]
FDA Requirements121.101; LIMITATIONS: GRAS SEQUESTRANT; GRAS MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE.
EPA Safer ChemicalChemical: Potassium citrate, anhydrous; Green circle - The chemical has been verified to be of low concern based on experimental and modeled data.
Hazard Classes and Categories · 2건

Not Classified

Not Classified

안전 및 보호

Protective Action Criteria (PAC) · 3건

2.1 [mg/m3]

23 [mg/m3]

140 [mg/m3]

독성 정보

Interactions12 OF 40 HEART PT TREATED WITH POTASSIUM CITRATE SHOWED SLIGHT MALABSORPTION OF VITAMIN B12. MECHANISM OF THE DISTURBANCE APPEARED TO BE ACIDIFICATION OF CONTENTS OF THE ILEUM.
Human Toxicity ExcerptsCONGENITAL MALFORMATIONS AND SURVIVAL IN RELATION TO THE FIRST TRIMESTER USE OF SPECIFIC DRUGS AND VACCINES ARE PRESENTED.

규제 정보

Regulatory Information · 5건

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 19-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14309

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Does not have an individual approval but may be used under an appropriate group standard

FDA Requirements121.101; LIMITATIONS: GRAS SEQUESTRANT; GRAS MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE.

화학 및 산업

약리 정보

FDA Pharmacological Classification · 5건

86R1NVR0HW

POTASSIUM CITRATE ANHYDROUS

Mechanisms of Action [MoA] - Alkalinizing Activity

Established Pharmacologic Class [EPC] - Metabolic Alkalinizer

Potassium citrate anhydrous is a Metabolic Alkalinizer. The mechanism of action of potassium citrate anhydrous is as an Alkalinizing Activity.

MeSH Pharmacological Classification · 2건

Agents that promote the excretion of urine through their effects on kidney function.

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.

용도 및 제조

Uses · 6건

Used as a food additive (sequestrant, stabilizer, and buffer), a preservative for cut flowers, and a medication (potassium supplement, diuretic, expectorant, and alkalizer); [HSDB] Used as chemical intermediate; [MSDSonline]

MEDICATION

MEDICATION (VET)

SEQUESTRANT FOOD ADDITIVE

STABILIZER, BUFFER IN FOODS

IN PRESERVATION OF CUT FLOWERS

U.S. Production · 2건

2023: 75,000 - <100,000 lb;2022: 75,000 - <100,000 lb;2021: 75,000 - <100,000 lb;2020: 50,000 - <250,000 lb

2023: 1,000,000 - <2,500,000 lb;2022: 2,500,000 - <4,000,000 lb;2021: 2,500,000 - <4,000,000 lb;2020: 1,000,000 - <2,500,000 lb

Consumer UsesSoil amendments (fertilizers);Emulsifier
Industry UsespH regulating agent;Soil amendments (fertilizers);Emulsifier
Methods of ManufacturingBY ADDING POTASSIUM BICARBONATE OR CARBONATE TO A SOLN OF CITRIC ACID UNTIL EFFERVESCENCE CEASES, FILTERING THE SOLN & EVAPORATION TO GRANULATION.
Formulations/Preparations · 3건

POTASSIUM CITRATE, NF. POWDER, NF. TABLETS, 2.3 MEQ OF K+ AND 0.8 MEQ OF C6H5O7(3-) (250 MG), 2.8 MEQ OF K+ AND 0.9 MEQ OF C6H5O7(3-) (300 MG), AND 5.6 MEQ OF K+ AND 1.8 MEQ OF C6H5O7(3-) (600 MG).

IT IS AT LEAST 99% PURE.

GRADES: TECHNICAL; CP; NF; FCC.

관련 반응

21건

연결된 노트

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