Tripotassium citrate
기본 정보
- CAS
7778-49-6- 표준 SMILES
O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[K+].[K+].[K+]- InChIKey
QEEAPRPFLLJWCF-UHFFFAOYSA-K- 분자식
- C6H5K3O7
- 평균 분자량
- 306.39 g/mol
- 단동위원소 질량
- 305.8946469
개요
Potassium citrate (anhydrous) is the anhydrous form of the tripotassium salt of citric acid. It has a role as a diuretic. It contains a citrate(3-).
이름 및 식별자
- 우선 이름
- Tripotassium citrate
- IUPAC
- tripotassium;2-hydroxypropane-1,2,3-tricarboxylate
- 영어명
- 1,2,3-Propanetricarboxylicacid,2-hydroxy-,potassiumsalt
- 분자식
- C6H9KO7
- 분자량
- 232.23
이름 및 동의어
TRIPOTASSIUM CITRATE866-84-2KaliksirLitocitPotassium citrate anhydrousPorekalKajosUrocit KSeltz-KK citrateCitric acid, tripotassium saltPotassium tribasic citrate
이름 더 보기
PotassiumCitrateBpTripotassium citratTripotassium Citrate,>98%PotassiumCitrate(FoodGrade)citric acid, potassium salthigh qualtiy Potassium CitrateTIANFU-CHEM CAS NO.7778-49-6 Tripotassium citrate2,3-propanetricarboxylicacid,2-hydroxy-potassiumsalt1,2,3-Propanetricarboxylicacid,2-hydroxy-,potassiumsalt2-Hydroxy-1,2,3-propanetricarboxylic acid tripotassium salt
ACALKA86R1NVR0HW1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium saltDTXSID8027325RefChem:933490Anhydrous, Potassium CitrateDTXCID907325212-755-5
데이터베이스 식별자
- CAS
7778-49-6、866-84-2- PubChem CID
- 13344
- DTXSID
DTXSID8027325- ChEMBL
CHEMBL1200458- ChEBI
CHEBI:64733- UNII
- 86R1NVR0HW
- EC Number
- 212-755-5、231-905-0
- Nikkaji
- J7.148J
물성
구조 계산 물성
- 극성 표면적
- 141 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 2
- 무거운 원자 수
- 16
- 형식 전하
- 0
- 복잡도
- 211
실험 및 물리화학적 성질
Chemical ClassesMetals -> Organic Acids, Metal Salts
CosmeticsBuffering; Chelating
pH
Between 7,5 and 9,0 (5 % aqueous solution)
THE AQ SOLN IS ALKALINE TO LITMUS; PH ABOUT 8.5
FragrancesFragrance Ingredient (1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt) -> IFRA transparency List
OdorODORLESS
TasteHAS COOLING, SALINE TASTE
Density1.98 @25 °C
Color/Form
WHITE CRYSTALS, GRANULES, OR POWDER
TRANSPARENT CRYSTALS
Solubility
1 G DISSOLVES IN 0.65 ML WATER
1 G DISSOLVES VERY SLOWLY IN 2.5 ML GLYCEROL
ALMOST INSOL IN ALCOHOL
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Physical Description
Liquid
Liquid; Large Crystals; Dry Powder
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 96.3% (572 of 594) of all reports.
Not Classified
Aggregated GHS information provided per 594 reports by companies from 4 notifications to the ECHA C&L Inventory.
This chemical does not meet GHS hazard criteria for 100% (14 of 14) of all reports.
Not Classified
Aggregated GHS information provided per 14 reports by companies from 2 notifications to the ECHA C&L Inventory.
유해성 정보
Regulatory Information
Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Tripotassium citrate (EC: 212-755-5)
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Human health tier I assessment
Hazards SummaryPotassium salts by mouth in doses less than 2 mEq/kg are usually not toxic in patients with normal renal function; [HSDB] May cause irritation; [MSDSonline]
화학 및 산업
약리 정보
Pharmacodynamics
Potassium citrate induces changes in the urine which renders urine less susceptible to the formation of crystals and stones from salts e.g. calcium oxalate, calcium phosphate and uric acid. Increased citrate levels in the urine will make complexation with calcium which decrease the calcium ion activity and decrease the chance for the formation of calcium phosphate crystals. Citrate also inhibits the spontaneous nucleation of calcium oxalate and calcium phosphate.
Mechanism of Action
After oral administration of potassium citrate, its metabolism yields alkaline load. Potassium Citrate therapy appears to increase urinary citrate mainly by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. In addition to raising urinary pH and citrate, Potassium Citrate increases urinary potassium by approximately the amount contained in the medication. In some patients, Potassium Citrate causes a transient reduction in urinary calcium.
Metabolism/MetabolitesPotassium Citrate is absorbed and the citrate is metabolised to bicarbonate.
FDA Pharmacological Classification
86R1NVR0HW
POTASSIUM CITRATE ANHYDROUS
Mechanisms of Action [MoA] - Alkalinizing Activity
Established Pharmacologic Class [EPC] - Metabolic Alkalinizer
Potassium citrate anhydrous is a Metabolic Alkalinizer. The mechanism of action of potassium citrate anhydrous is as an Alkalinizing Activity.
MeSH Pharmacological Classification
Agents that promote the excretion of urine through their effects on kidney function.
Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.
Absorption, Distribution and ExcretionUrinary; less than 5% unchanged.
용도 및 제조
관련 반응
21건
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