기본 정보
- CAS
72487-32-2- 표준 SMILES
C[C@H](CCc1ccccc1)NC[C@H](O)c1ccc(O)c(C(N)=O)c1- InChIKey
SGUAFYQXFOLMHL-ACJLOTCBSA-N- 분자식
- C19H24N2O3
- 평균 분자량
- 328.4 g/mol
- 단동위원소 질량
- 328.17869263
개요
(R,R)-labetalol is a 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide that has 1R,2R-configuration. It is a conjugate base of a dilevalol(1+).
이름 및 식별자
- 우선 이름
- (+)-Labetalol
- IUPAC
- 2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-4-phenylbutan-2-yl]amino]ethyl]benzamide
- 현지명
- 딜레발롤
- 영어명
- DILEVALOL
- 분자식
- C19H24N2O3
- 분자량
- 328.41
이름 및 동의어
Dilevalol75659-07-3DilevalolumP6629XE33TBenzamide, 2-hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-, (R-(R*,R*))-Benzamide, 2-hydroxy-5-((1R)-1-hydroxy-2-(((1R)-1-methyl-3-phenylpropyl)amino)ethyl)-(+)-LabetalolR,R LabetalolR,R-LabetalolLabetalol (r,r)-Labetalol, (R,R)-RefChem:905472
이름 더 보기
딜레발롤UnicardDilevaolSch-19927DILEVALOL HCLDilevalolum [latin]
(R,R)-Labetalol2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-4-phenylbutan-2-yl)amino)ethyl)benzamide72487-32-22-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-4-phenylbutan-2-yl]amino]ethyl]benzamide2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-1-methyl-3-phenylpropyl]amino]ethyl]benzamideDilevalonLevadil2-Hydroxy-5-((1R)-1-hydroxy-2-(((1R)-1-methyl-3-phenylpropyl)amino)ethyl)benzamide
데이터베이스 식별자
- CAS
72487-32-2、75659-07-3- PubChem CID
- 134044
물성
구조 계산 물성
- XLogP
- 3.1
- 극성 표면적
- 95.6 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 8
- 무거운 원자 수
- 24
- 형식 전하
- 0
- 복잡도
- 385
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
물리화학적 성질
- 끓는 점
- 552.7 · 552.7±50.0 °C(Predicted)
- 밀도
- 1.2 · 1.200±0.06 g/cm3(Predicted)
- 산도 계수 (pKa)
- 8.21 · 8.21±0.31(Predicted)
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.
응용 분야
개요Dilevalol is a "dual-mechanism" antihypertensive reportedly suitable for a wide range of patients. Its partial beta2-agonist action is expected to induce vasodilation, whereas its beta1-antagonist component may protect against stress-induced hemodynamic charges without altering the cardiac output. Dilevalol is the R,R-isomer of labetalol.
용도Specific competitive antagonist at both α-and β-adrenergic receptor sites. Antihypertensive.
공급사19 곳
江苏艾康生物医药研发有限公司025-58851090 19370895928 · [email protected]
北京科迈启医药科技有限公司15910349257 15910349257 · [email protected]
湖北瑞玛标物科技有限公司15787879035 15787875101 · [email protected]
LGM Pharma
관련 반응
0건
현재 필터 조건에 해당하는 반응 기록이 없습니다.
화합물 노트
불러오는 중…