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(+-)-메타돈염산염-DEA

Methadone Hydrochloride

HCID 14184
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
1095-90-5
표준 SMILES
CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1.Cl
InChIKey
FJQXCDYVZAHXNS-UHFFFAOYSA-N
분자식
C21H28ClNO
평균 분자량
345.9 g/mol
단동위원소 질량
345.1859422

개요

Methadone hydrochloride is a hydrochloride. It contains a methadone.

이름 및 식별자

우선 이름
Methadone Hydrochloride
IUPAC
6-(dimethylamino)-4,4-diphenylheptan-3-one;hydrochloride
현지명
(+-)-메타돈염산염-DEA
영어명
(+-)-Methadone hydrochloride--DEA
분자식
C21H28ClNO
분자량
345.90612

이름 및 동의어

Methadone hydrochlorideAlgolysin1095-90-5ButalginFenadoneMecodinPhenadone hydrochlorideDolofin hydrochlorideKetalgin hydrochlorideHeptadonAdanon hydrochlorideDolophine hydrochloride
이름 더 보기
(+-)-메타돈염산염-DEAtussalalgidonmacodinmiadonedepridolmephenonmoheptan
WestadoneAN-148AlthoseDTXSID20205016-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochlorideMethadone hydrochloride cii4,4-Diphenyl-6-dimethylamino-3-heptanone hydrochlorideNSC-19600

데이터베이스 식별자

CAS
1095-90-5、125-56-4
PubChem CID
14184
DTXSID
DTXSID2020501
ChEMBL
CHEMBL1200825
ChEBI
CHEBI:50140
UNII
229809935B
EC Number
214-140-7、621-092-4

물성

구조 계산 물성

극성 표면적
20.3 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
2
회전 가능 결합 수
7
무거운 원자 수
24
형식 전하
0
복잡도
346

실험 및 물리화학적 성질

Human Drugs · 3건

Breast Feeding; Lactation; Milk, Human; Analgesics, Opioid; Narcotics; Antitussive Agents

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List

물리화학적 성질

저장 조건
2 · 2-8°C
용해도
2 O: · H2O: >50 mg/mL, 투명, 무색~노란색
물리적 상태
가루
색상
흰색에서 황백색까지

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 6건

Danger

H300 (94.8%): Fatal if swallowed [Danger Acute toxicity, oral]

P203, P233, P260, P261, P262, P264, P270, P271, P272, P280, P284, P301+P316, P302+P352, P304+P340, P316, P318, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 116 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral]

유해성 정보

Regulatory InformationMethadone hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride: Environment tier I assessment
Fire Hazards · 3건

· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Health Hazards · 3건

· Highly toxic, may be fatal if inhaled, ingested or absorbed through skin.

· Highly toxic, may be fatal if inhaled, ingested or absorbed through skin.

· TOXIC; may be fatal if inhaled, ingested or absorbed through skin.

DOT ID and Guide · 3건

3249 151

1851 151

3248 131

DOT Hazard Classification · 6건

화학 및 산업

약리 정보

Metabolism/Metabolites · 1건

Hepatic. Cytochrome P450 enzymes, primarily CYP3A4, CYP2B6, and CYP2C19 and to a lesser extent CYP2C9 and CYP2D6, are responsible for conversion of methadone to EDDP and other inactive metabolites, which are excreted mainly in the urine. Route of Elimination: The elimination of methadone is mediated by extensive biotransformation, followed by renal and fecal excretion. Unmetabolized methadone and its metabolites are excreted in urine to a variable degree. Half Life: 24-36 hours

FDA Pharmacological Classification · 2건

METHADONE HYDROCHLORIDE

Full Opioid Agonists [MoA]; Opioid Agonist [EPC]

MeSH Pharmacological Classification · 3건

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.

용도 및 제조

UsesFor the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence, and pain (A308).

관련 반응

2건
반응 기록 만들기
HRID 83479 반응식
HRID 83479반응물로uspto-grants-2014_09
HRID 2396431 반응식
HRID 2396431반응물로uspto-grants-1996_02

화합물 노트

불러오는 중…

이 페이지에서기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트

Medicine, liquid, flammable, toxic, n.o.s

UN3248

Class 3 Flammable and combustible liquid (49 eCFR § 173.120)

Class 3 Flammable and combustible liquid (49 eCFR § 173.120)

PG II: the degree of danger presented by the material is medium

Medicine, liquid, toxic, n.o.s

Hazard Classes and Categories · 2건

Acute Tox. 2 (94.8%)

Acute Tox. 3 (97.5%)

안전 및 보호

Accidental Release Measures · 6건

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

First Aid · 3건

General First Aid:

General First Aid:

General First Aid:

Exposure Control and Personal Protection · 3건

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

Isolation and Evacuation · 3건

Immediate precautionary measure

Immediate precautionary measure

Immediate precautionary measure

Emergency Response Planning Guidelines · 3건

Small Fire

Small Fire

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

독성 정보

Treatment · 1건

Primary attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. If a non-tolerant person, takes a large dose of methadone, effective opioid antagonists are available to counteract the potentially lethal respiratory depression. (L1712)

Health Effects · 1건

Bradycardia and hypotension. In severe overdosage, particularly by the intravenous route, apnea, circulatory collapse, cardiac arrest, and death may occur (RxList, A308). Medical problems can include congested lungs, liver disease, tetanus, infection of the heart valves, skin abscesses, anemia and pneumonia. Death can occur from overdose.

Exposure Routes · 1건

Inhalation (MSDS, RxList, A308); dermal (MSDS, RxList, A308); ingestion (MSDS, RxList, A308); intravenous injection (MSDS, RxList, A308). Well absorbed following oral administration. The bioavailability of methadone ranges between 36 to 100%.

Toxicity Summary · 1건

Methadone is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine, the most prominent of which involves the central nervous system and organs composed of smooth muscle. The principal therapeutic uses for methadone are for analgesia and for detoxification or maintenance in opioid addiction. The methadone abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe. Some data also indicate that methadone acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor. The contribution of NMDA receptor antagonism to methadone's efficacy is unknown. Other NMDA receptor antagonists have been shown to produce neurotoxic effects in animals.

Signs and SymptomsIn severe overdosage, particularly by the intravenous route, apnea, circulatory collapse, cardiac arrest, and death may occur.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Drug Induced Liver Injury · 6건

Drug Induced Liver Injury Rank (DILIrank 2.0)

Methadone hydrochloride

Ambiguous-DILI-concern

3

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

안전 데이터

wgk
3
rtecs
MJ6300000
ridadr
UN 3249
risk_code
25
hazard_code
T
safety_code
45
포장분류
II/III
위험 등급
6.1