염산 메트포르민
염산메트포르민 · 염산메트포르민(METFORMINHYDROCHLORIDE) · METFORMIN HCL · GLUCOPHAGE · big · MetforMin HCl USP · Metformin hydrochloride CRS · 3-(diaminomethylidene)-1,1-dimethylguanidine
식별자 및 물리적 특성
| CAS No. | 1115-70-4 |
|---|---|
| 분자식 | C4H12ClN5 |
| 평균 분자량 | 165.62 g/mol |
| SMILES | CN(C)C(=N)N=C(N)N.Cl |
| InChIKey | OETHQSJEHLVLGH-UHFFFAOYSA-N |
| PubChem CID | 14219 |
| ChEMBL | CHEMBL1703 |
| ChEBI | CHEBI:6802 |
| EC No. | 214-230-6 |
| 현지명 | 염산 메트포르민 |
화학 및 물리적 성질
| 극성 표면적 | 91.5 |
|---|---|
| 수소 결합 공여자 수 | 4 |
| 수소 결합 수용자 수 | 1 |
| 회전 가능 결합 수 | 2 |
| 무거운 원자 수 | 10 |
| 형식 전하 | 0 |
| 복잡도 | 132 |
| Human Drugs | Breast FeedingLactationMilk, HumanHypoglycemic AgentsBiguanidesFDA approved drugs -> Active ingredient |
| Decomposition | Hazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx), hydrogen chloride gas. /Metformin hydrochloride/When heated to decomposition it emits toxic fumes of /nitric oxides/. |
| Stability/Shelf Life | Stable under recommended storage conditions. /Metformin hydrochloride/ |
| Dissociation Constants | pKa = 12.4 /Metformin hydrochloride/ |
| Collision Cross Section | 123 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| Other Experimental Properties | MW: 165.63. Prisms from water, MP 232 °Ccrystals from propanol, MP 218-220 °C. Freely soluble in waterslightly soluble in alcohol. Practically insoluble in ether, chloroform, acetone, methylene chloride. /Metformin hydrochloride/MW: 315.76 /Metformin p-chlorophenoxyacetate (salt)/MW: 646.70 /Metoformin embonate/ |
| 녹는점 | 223-226 °C(lit.) |
| 밀도 | 1.36[at 20℃] |
| 증기압 | 0.001Pa at 25℃ |
| 인화점 | 9℃ |
| 저장 조건 | 2-8°C |
| 용해도 | 물에 잘 녹고, 알코올에 약간 녹고, 아세톤과 염화메틸렌에는 거의 녹지 않습니다. |
| pKa(산도 계수) | 12.4[at 20 ℃] |
| 물리적 상태 | 가루 |
| 색상 | 하얀색 |
| 용해도 | 물(50mg/ml), 에탄올 및 DMSO(50mM)에 용해됩니다. |
| Merck | 14,5938 |
| 헨리 상수 | 1.3×1010 mol/(m3Pa) at 25℃, HSDB (2015) |
| BCS Class | 3 |
| 안정성 | 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 증류수 용액은 -20°에서 최대 2개월 동안 보관할 수 있습니다. |
| InChI | 1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)1H |
| InChIKey | OETHQSJEHLVLGH-UHFFFAOYSA-N |
| SMILES | Cl[H].CN(C)C(=N)NC(N)=N |
| LogP(분배 계수) | -3.5 at 20℃ |
화학적 성질
Crystalline Solid
안전 및 규제
| GHS 분류 | WarningH302 (99.6%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 265 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H302: Harmful if swallowed [Warning Acute toxicity, oral] |
|---|---|
| 규제 정보 | Status: Active Update: 13-08-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/18705Metformin hydrochloride: Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | IMAP assessments - Imidodicarbonimidic diamide, N,N-dimethyl-, monohydrochloride: Environment tier I assessment |
| FDA 요건 | The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including metformin hydrochloride, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Metformin hydrochloride/ |
| Hazard Classes and Categories | Acute Tox. 4 (99.6%) |
| Hazardous Reactivities and Incompatibilities | Incompatible materials: Strong oxidizing agents. /Metformin hydrochloride/ |
| 소화 절차 | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. /Metformin hydrochloride/Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary. /Metformin hydrochloride/ |
| 보관 조건 | Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 °C. Storage class (TRGS 510): Non Combustible Solids. /Metformin hydrochloride/ |
| 정리 방법 | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. /Metformin hydrochloride/ |
용도
개요
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.
용도
Metformin hydrochloride may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations and human plasma samples by analytical techniques.
일반 설명
1,1-Dimethylbiguanide hydrochloride (metformin) is a strong base. It forms well defined salts and possessing excellent coordination capacity with transition metals, forming highly colored bidentate chelate complexes. Metformin (MET) exists in various forms: diprotonated (H2MET)2+ in strong acidic solution, monoprotonated (HMET)+ in weak acid, MET in neutral and deprotonated (MET)- in strong alkali solution. It is an oral antidiabetic drug. Pharmacokinetics of metformin has been studied. Determination of metformin in human plasma has been described by simple HPLC-UV method. Metformin is reported to increase plasma active glucagon-like peptide-1 (GLP-1) in humans.