D-Glutamine

HCID 145815

기본 정보

CAS: 5959-95-5
표준 SMILES: NC(=O)CC[C@@H](N)C(=O)O
InChIKey: ZDXPYRJPNDTMRX-GSVOUGTGSA-N
분자식: C5H10N2O3
평균 분자량: 146.14 g/mol
단동위원소 질량: 146.06914218

개요

D-glutamine is the D-enantiomer of glutamine. It has a role as a mouse metabolite. It is a D-alpha-amino acid and a glutamine. It is a conjugate base of a D-glutaminium. It is a conjugate acid of a D-glutaminate. It is an enantiomer of a L-glutamine. It is a tautomer of a D-glutamine zwitterion.

이름 및 식별자

우선 이름: D-Glutamine
IUPAC: (2R)-2,5-diamino-5-oxopentanoic acid
영어명: D-Glutamine
분자식: C5H10N2O3
분자량: 146.14

이름 및 동의어

D-glutamine5959-95-5D-2-Aminoglutaramic acidGlutamine, D-(2R)-2-amino-4-carbamoylbutanoic acid(2R)-2,5-diamino-5-oxopentanoic acid(R)-2,5-diamino-5-oxopentanoic acidDTXSID604634563HB36CA2YDTXCID4026345CHEBI:17061RefChem:583856

이름 더 보기

D-Gln-OHD-GIn-0HCAS5959-95-5D(-)-GLUTAMINED-Glutamine>D-Glutamine99+%dextro-glutamine

673-968-0H-D-Gln-OHD-GlnMFCD00065607(r)-2-amino-4-carbamoyl-butyric acidNCGC00163333-01M02933DGN

데이터베이스 식별자

CAS: 5959-95-5
PubChem CID: 145815
DTXSID: DTXSID6046345
ChEMBL: CHEMBL1232207
ChEBI: CHEBI:17061
UNII: 63HB36CA2Y
EC Number: 673-968-0
Nikkaji: J9.211H

물성

구조 계산 물성

XLogP: -3.1
극성 표면적: 106 Å²
수소 결합 공여자 수: 3
수소 결합 수용자 수: 4
회전 가능 결합 수: 4
무거운 원자 수: 10
형식 전하: 0
복잡도: 146

실험 및 물리화학적 성질

Physical DescriptionSolid

물리화학적 성질

녹는점: 184 · 184-185 °C
끓는 점: 265.74 °C · 265.74°C (rough estimate)
밀도: 1.3394 · 1.3394 (rough estimate)
굴절률: -33 ° · -33 ° (C=5, 5mol/L HCl)
저장 조건: Keep in dark place,Inert atmosphere,Room temperature
용해도: 물(약간 용해됨, 초음파 처리)
산도 계수 (pKa): 2.27 · 2.27±0.10(Predicted)
물리적 상태: 가루
색상: 하얀색
수용성: 42.53 g/L · 42.53g/L(온도 미표시)
BRN: 1723796 · 1723796
주요 응용: 세포 분석
InChI: 1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m1/s1
InChIKey: ZDXPYRJPNDTMRX-GSVOUGTGSA-N
SMILES: N[C@H](CCC(N)=O)C(O)=O
LogP: -1.576 · -1.576 (est)

화학적 성질

white crystalline powder

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 3 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

안전 데이터

wgk: 3
HS 번호: 29241900
risk_code: 36/37/38
hazard_code: Xi
safety_code: 36/37/39-26-27-24/25
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

약리 정보

Cellular LocationsCytoplasm

용도 및 제조

UsesUse (kg; approx.) in Germany (2009): >1000

응용 분야 · 2건

용도D-Glutamine is an unnatural isomer of L-Glutamine (G597000) that is present in human plasma an is a source of liberated ammonia. D-Glutamine can be synthesized by enzymatic means or can be found in cheeses, wine and vinegars as well. It is often used to determine the activity of Glutamine synthetase, an enzyme that is commonly found in the mammalian liver and brain that controls the use of nitrogen in cells.

일반 설명Glutamine is a non-essential and the most abundant free amino acid present in the human body. It is an important component of proteins and is one of the 20 proteinogenic amino acids. It forms 5-6% of bound amino acids.