알비글루타이드
Albugon
기본 정보
- CAS
782500-75-8- 표준 SMILES
CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](C)NC(=O)[C@@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C(C)C- InChIKey
JYDZPPZAYQTOIV-OTSUTHPESA-N- 분자식
- C148H224N40O45
- 평균 분자량
- 3,283.6 g/mol
- 단동위원소 질량
- 3,281.6469252
이름 및 식별자
- 우선 이름
- Albugon
- IUPAC
- (4S)-5-[[2-[[(2S,3S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2R)-1-[[(2R)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[2-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-4-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]acetyl]amino]-5-oxopentanoic acid
- 현지명
- 알비글루타이드
- 영어명
- Albiglutide
- 분자식
- C148H223N39O46
- 분자량
- 3284.58792
이름 및 동의어
AlbugonAlbiglutide [USAN:INN]UNII-5E7U48495EHSDB 8282GLXC-22544Albiglutide pound Acetate pound(c)AT41897GSK 716155PD078276Albugon, a recombinant human glucagon-like peptide 1-albumin protein알비글루타이드albiglutide
이름 더 보기
NaliglutideAlbiglutide FragmentAlbiglutide（Acetate）Albiglutide USP/EP/BPResearch Grade AlbiglutideAlbiglutide Eperzan Tanzeum
물성
구조 계산 물성
- XLogP
- -14.6
- 극성 표면적
- 1,390 Ų
- 수소 결합 공여자 수
- 49
- 수소 결합 수용자 수
- 50
- 회전 가능 결합 수
- 109
- 무거운 원자 수
- 233
- 형식 전하
- 0
- 복잡도
- 7,620
물리화학적 성질
- 저장 조건
- -20 °C · Store at -20°C
- 수용성
- 100 mg/mL · Water: 100 mg/mL (30.45 mM);
- InChIKey
- OGWAVGNOAMXIIM-VTAHJYCESA-N
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- 유해 물질 데이터
- 782500-75-8(Hazardous Substances Data)
화학 및 산업
응용 분야
일반 설명Albiglutide (also known as naliglutide, GSK 716155) isa sequential dimer of GLP-1(7–36)(Ala8→Gly) covalentlylinked to modified human serum albumin (i.e., it is a “fusionprotein” with modified HSA). This molecule is currentlywell into phase III clinical trials. Although albiglutide,if marketed (Syncria, GlaxoSmithKline), will—likeexenatide—be administered by injection, the half-life andduration of 6 to 7 days would allow for weekly administration.
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