2-에틸헥실 디페닐 인산

This compound is not very flammable but any fire involving this compound may produce dangerous vapors. You should evacuate the area. All firefighters should wear full-body protective clothing and use self-contained breathing apparatuses. You should extinguish any fires involving this chemical with a dry chemical, carbon dioxide, foam, or halon extinguisher. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8 °C

ACCIDENTAL RELEASE MEASURES. Personal precautions, protective equipment and emergency procedures: Avoid breathing vapours, mist or gas.; Environmental precautions: Do not let product enter drains.; Methods and materials for containment and cleaning up: Keep in suitable, closed containers for disposal.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Product: Offer surplus and non-recyclable solutions to a licensed disposal company.; Contaminated packaging: Dispose of as unused product.

Appropriate engineering controls: General industrial hygiene practice.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Eye/face protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves.

Body Protection: impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK (EU EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/

EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, flow through, 21-23 °C, pH 8.0-8.5, hardness 160-180 mg/L CaCO3, alkalinity 122-128 mg/L CaCO3, dissolved oxygen 7.5-8.0 mg/L; Concentration: 47 ug/L for 21 days; Effect: intoxication, immobilization

EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, flow through, 21-23 °C, pH 8.0-8.5, hardness 160-180 mg/L CaCO3, alkalinity 122-128 mg/L CaCO3, dissolved oxygen 7.5-8.0 mg/L; Concentration: 53 ug/L for 7 days; Effect: intoxication, immobilization

EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, flow through, 20-23 °C, pH 7.0-8.5, hardness 120-250 mg/L CaCO3, alkalinity 120-250 mg/L CaCO3, dissolved oxygen 6.0-9.3 mg/L; Concentration: 150 ug/L for 48 hr; Effect: intoxication, immobilization

EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, flow through, 20-23 °C, pH 7.0-8.5, hardness 120-250 mg/L CaCO3, alkalinity 120-250 mg/L CaCO3, dissolved oxygen 6.0-9.3 mg/L; Concentration: 600 ug/L for 24 hr; Effect: intoxication, immobilization

For more Ecotoxicity Values (Complete) data for DIPHENYL-2-ETHYLHEXYL PHOSPHATE (6 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 32,200(SRC), determined from a structure estimation method(2), indicates that diphenyl-2-ethylhexyl phosphate is expected to be immobile in soil(SRC). Volatilization of diphenyl-2-ethylhexyl phosphate from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 5.42X10-5 atm-cu m/mole(3). However, adsorption to soil is expected to attenuate volatilization(SRC). Diphenyl-2-ethylhexyl phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.3X10-5 mm Hg at 25 °C(2). Biodegradation data for diphenyl-2-ethylhexyl phosphate in soil were not available(SRC, 2014). Diphenyl-2-ethylhexyl phosphate was biodegraded 5-99% in aquatic systems(4).

AQUATIC FATE: In outdoor experiments performed in small, artificial ponds, 62% of the applied diphenyl-2-ethylhexyl phosphate was found adsorbed to sediment after 1 hr; 24% of the amount originally applied was adsorbed after 360 days(1). Volatilization from water surfaces is expected(2) based upon a Henry's Law constant of 5.42X10-5 atm-cu m/mole(1). Using this Henry's Law constant and an estimation method(2), volatilization half-lives for a model river and model lake are 36 hours and 17 days, respectively(SRC). However, in artificial pond experiments, volatilization of diphenyl-2-ethylhexyl phosphate was 8% over a 21 day period; volatilization was low due to adsorption to sediment(1). Diphenyl-2-ethylhexyl phosphate may slowly hydrolyze in the environment at high alkalinity, based on an estimated half-life of 117 days at pH 9(3). According to a classification scheme(4), BCFs of 194-735 in carp (Cyprinus carpio)(5) and 1147 and 1481 in rainbow trout fry (Salmo gairdneri)(6), suggest the bioconcentration in aquatic organisms is high to very high(SRC). Biodegradation half-lives of 5.3 and 4.5 days using river water and eutrophic pond water inoculum, respectively(7), suggest that biodegradation may be an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diphenyl-2-ethylhexyl phosphate, which has an estimated vapor pressure of 3.3X10-5 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase diphenyl-2-ethylhexyl phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 9 hours(SRC), calculated from its rate constant of 4.0X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase diphenyl-2-ethylhexyl phosphate may be removed from the air by wet and dry deposition(SRC). Diphenyl-2-ethylhexyl phosphate does not contain chromophores that absorb at wavelengths >290 nm(3) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

Diphenyl-2-ethylhexyl phosphate was identified in US Food & Drug Administration (FDA) Total Diet Studies for adults, conducted from Oct 1979 to Sept 1980, 5 of 240 total food composites contained 1.3-12 ppm, 1 meat fish and poultry composite at 2.0 ppm, and 4 oils and fats composites had 1.3-12 ppm(1). In the FDA Total Diet Studies for infants and toddlers, conducted from Oct 1979 to Sept 1980, 0 of 13 infant diet composites and 2 of 13 toddler diet composites of meat, fish, and poultry contained diphenyl-2-ethylhexyl phosphate at 0.030-0.261 ppm and 1 of 13 sugar and adjuncts composites had 0.330 ppm(2). In the FDA total diet studies for adults, conducted from Oct 1980 to Mar 1982, diphenyl-2-ethylhexyl phosphate was found in 11 of 324 total food composites at 0.070-7.10 ppm, 1 meat, fish and poultry composite at 0.070 ppm, 1 grain & cereal products composite at 0.485 ppm, and 9 oils and fats composites at 0.395-7.10 ppm(3). In the FDA Total Diet Studies for infants and toddlers conducted from Oct 1980 to Mar 1982, diphenyl-2-ethylhexyl phosphate was found in 1 of 13 infant diet composites of meat, fish and poultry products at 0.454 ppm and 3 of 13 toddler diet composites of sugar and adjuncts at 0.070-0.211 ppm(4). Diphenyl-2-ethylhexyl phosphate was found in a margarine/wrapper sample composite at 50 ppm, in margarine at 20 ppm, and in a plastic bread bag at 400 ppm but only 0.5 ppm in the bread itself(5). In a 10 year revised market basket study conducted by the FDA, diphenyl-2-ethylhexyl phosphate was detected in 146 of 17,050 samples in 41 of 230 different food types at an average of 0.5120 ug/g; the study was run from 1982 to 1991(6).

IDENTIFICATION AND USE: Diphenyl-2-ethylhexyl phosphate is a liquid. It is used as a plasticizer for food-wrapping films, for films for tubings for skinless sausages, and for other meat packaging. This compound is also the main component in certain nonflammable hydraulic fluids used in large aircraft. HUMAN EXPOSURE AND TOXICITY: The chemical was measured in paired indoor air and dust samples from daycare centers and the level was correlated with the respective metabolite levels in urine of children. In other studies diphenyl-2-ethylhexyl phosphate was given to humans. The amount of phenol (in all forms) found was 96%. The amounts in the feces and urine were respectively 83% and 13% in human subjects. The intestinal absorption of the chemical in humans was low. ANIMAL STUDIES: In a 90 day study rats were fed diphenyl-2-ethylhexyl phosphate. All doses showed changes in blood chemistry, liver and adrenals. In a one-generation reproductive study in rats F1 pup body weight gain was reduced and 21-day survival was reduced in the high-dose pup group. A dose-related increase in relative and absolute liver and adrenal weight was seen in each sex of the parental and F1 generation. Mammalian cell mutation assay with Fischer mouse lymphoma L5178Y line was negative. In a microbial cell mutation assay, Salmonella typhimurium TA-1535, TA-1537, TA-1538, TA-98, TA-100 and Saccharomyces cerevisiae D4 treated with diphenyl-2-ethylhexyl phosphate were negative for mutagenicity with and without metabolic activation. In an in vivo bone marrow chromosome study in rat no statistically significant differences in chromosome structural defects or number between treated and control animals were found. In rats the major metabolites detected in the urine were diphenyl phosphate (DPP) and phenol. p-Hydroxyphenyl phenyl phosphate (OH-DPP) and monophenyl phosphate (MPP) were also identified as minor metabolites.

The average intake of diphenyl-2-ethylhexyl phosphate as determined in US Food and Drug Administration (FDA) Total Diet Studies for adults, conducted from Oct 1979 to Sept 1980 was 126 ug/day(1). The average intake during the same time period for toddlers was 4.21 ug/day(2). Results for the FDA adult total diet study, Oct. 1980 to March 1982, included an average intake of 64.3 ug/day of diphenyl-2-ethylhexyl phosphate(3). The average intake during the same time period for infants was 0.741 ug/day and for toddlers it was 1.04 ug/day(4).

The US Food and Drug Administration market basket surveys done April 1982-April 1984(1), June 1984-April 1986(2) and July 1986- April 1991(3), found that the average intake of diphenyl-2-ethylhexyl phosphate (ng/kg body weight/day) for each of the following age groups:[Table#1126]

EPA has released the first beta version (version 0.5) of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The beta version of the iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays; See the data in Chemical Explorer/[USEPA; ICSS Dashboard Application; Available from, as of June 27, 2014: http://actor.epa.gov/dashboard/]

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of September 2, 2014: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=1241-94-7]

The concentration of diphenyl-2-ethylhexyl phosphate in sludge samples taken from 11 sewage treatment plants located throughout Sweden was 320-4600 ng/g dry weight, samples were collected 2002 to 2003(1). Diphenyl-2-ethylhexyl phosphate was not detected (detection limit not reported) in samples from three waste water treatment plants located in Galicia, Spain; samples were collected Nov 2007, Feb, Jun and Sep 2008(2).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of diphenyl-2-ethylhexyl phosphate can be estimated to be 32,200(SRC). According to a classification scheme(2), this estimated Koc value suggests that diphenyl-2-ethylhexyl phosphate is expected to be immobile in soil. In outdoor experiments performed in small, artificial ponds, 62% of the applied diphenyl-2-ethylhexyl phosphate was found adsorbed to sediment after 1 hr; 24% of the amount originally applied was adsorbed after 360 days(3).

The frequency of chromosome aberrations was determined in the bone marrow cells of Sprague-Dawley rats exposed by oral gavage to a single dose of 2-ethylhexyl diphenyl phosphate. Forty eight animals per group (24 male and 24 female) received dosages of 0, 1500, 5000 and 15000 mg/kg test article in corn oil. Statistically significant (KW-ANOVA, p < 0.05) differences in the percent aberrant cells, mean number of aberrations per cell, mean mitotic index, or mean modal number were not observed at any dose level. The dose levels were chosen based on the results of a preliminary range finding study and the previously determined LD50. Clinical observations of dose related toxicity during the test included soft feces, urine stains, depression, rough coat, red stains on nose and eyes, hunching and decreased body weights. Additionally, mortality was observed in five animals in the mid dose group.

/SURVEILLANCE/ Organophosphate (OP) flame retardants and plasticizers are chemicals that have been used in large quantities in diverse consumer and building-related products for decades. In the present study, OPs were measured in paired indoor air and dust samples from 63 daycare centers in Germany. Moreover, the urine of 312 children between 22 and 80 months old who attend these facilities was analyzed for the presence of eight OP metabolites. Tri-(2-butoxyethyl)-phosphate (TBEP), tris-(2-chloroisopropyl) phosphate (TCPP), and tri-n-butyl-phosphate (TnBP) were present in low concentrations in indoor air, with median values of 49ng/cu m, 2.7ng/cu m, and 2.2ng/cu m, respectively. In dust, median values of 225mg/kg for TBEP, 2.7mg/kg for TCPP, 1.1mg/kg for diphenyl(2-ethylhexyl) phosphate, and 0.5mg/kg for tri-phenyl-phosphate (TPhP) were found. In the urine samples, the metabolites di-phenyl-phosphate, di-n-butyl-phosphate, and di-(2-butoxyethyl)-phosphate had median values (95th percentiles) of 0.8ug/L (4.0ug/L), 0.2ug/L (0.9ug/L), and 2.0ug/L (10.7ug/L), respectively. A significant correlation was found between the dust and air samples in the levels of TnBP, tris(2-chloroethyl) phosphate (TCEP), and TBEP. For TCEP and TBEP, significant correlations were also observed between the levels in dust and the respective metabolite levels in urine. For TCEP, there was also a significant correlation between the concentration in indoor air and metabolite levels in urine. Based on the 95th percentile in dust and air in our study and data from residences in a previously published study, the daily intake of the most abundant OP (TBEP) is high (i.e., 3.2ug/kg b.w.). This level is approximately 6.4% of the reference dose (RfD) established by the NSF, U.S.A. Overall, the study shows that daycare centers are indoor environments that contribute to OP exposure.

Diphenyl-2-ethylhexyl phosphate's production and use as plasticizer(1) may result in its release to the environment through various waste streams(SRC). Diphenyl-2-ethylhexyl phosphate is approved for use in food packaging and may leach into food(1).

Diphenyl-2-ethylhexyl phosphate is an indirect food additive for use only as a component of adhesives.

Substances classified as plasticizers, when migrating from food-packaging material shall include ... diphenyl-2-ethylhexyl phosphate.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Phosphoric acid, 2-ethylhexyl diphenyl ester is included on this list. Effective date: 10/04/82; Sunset date: 10/04/92.