카바민 산
카르바민산 · 카바민산 · CI 75470 · E120 · CARMINE RED · coccinic acid · CARMINE ALUMINUM LAKE · Carminic
식별자 및 물리적 특성
| CAS No. | 1260-17-9 |
|---|---|
| 분자식 | C22H20O13 |
| 평균 분자량 | 492.4 g/mol |
| 단동위원소 질량 | 492.09039069 g/mol |
| SMILES | Cc1c(C(=O)O)c(O)cc2c1C(=O)c1c(O)c([C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(O)c(O)c1C2=O |
| InChIKey | DGQLVPJVXFOQEV-NGOCYOHBSA-N |
| PubChem CID | 14749 |
| ChEMBL | CHEMBL1366408 |
| EC No. | 215-724-4 |
| 현지명 | 카바민 산 |
화학 및 물리적 성질
| XLogP | 0.5 |
|---|---|
| 극성 표면적 | 243 |
| 수소 결합 공여자 수 | 9 |
| 수소 결합 수용자 수 | 13 |
| 회전 가능 결합 수 | 3 |
| 무거운 원자 수 | 35 |
| 형식 전하 | 0 |
| 복잡도 | 864 |
| Physical Description | Red crystals in methanolbright red powderdeep red color in water[HSDB] |
| 녹는점 | 136 °C |
| 끓는 점 | 506.2°C (rough estimate) |
| 밀도 | 1.4504 (rough estimate) |
| 굴절률 | 1.6000 (estimate) |
| 인화점 | 12℃ |
| 저장 조건 | room temp |
| 용해도 | 30g/L |
| 물리적 상태 | 결정성 분말 |
| pKa(산도 계수) | 1.62±0.20(Predicted) |
| 색상 | 빨간색에서 진한 빨간색까지 |
| pH | 1.6 (10g/l, H2O, 20℃) |
| 냄새 | 냄새 없는 |
| 용해도 | 1.298g/L(상온) |
| Merck | 14,1843 |
| BRN | 71651 |
| 주요 응용 | 진단 검사 제조혈액학조직학 |
| InChIKey | DGQLVPJVXFOQEV-JNVSTXMASA-N |
| SMILES | Cc1c(C(O)=O)c(O)cc2C(=O)c3c(O)c(O)c([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(O)c3C(=O)c12 |
| LogP(분배 계수) | 1.532 (est) |
| EPA | C.I. Natural Red 4 (1260-17-9) |
화학적 성질
Cochineal extract is a concentrated solution obtained after removing alcohol from an aqueous–alcoholic extract of cochineal (Dactylopius coccus Costa, also called Coccus cati L.). This extract is used as a color additive, the primary colorant being carminic acid.
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 100% (298 of 298) of all reports.Not ClassifiedReported as not meeting GHS hazard criteria by 298 of 298 companies. For more detailed information, please visit ECHA C&L website.Aggregated GHS information provided per 298 reports by companies from 1 notifications to the ECHA C&L Inventory.Reported as not meeting GHS hazard criteria per 298 of 298 reports by companies.There are 0 notifications provided by 0 of 298 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| 규제 정보 | Chemical: CarmineStatus: Active Update: 13-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/28382Carmine: Does not have an individual approval but may be used under an appropriate group standard |
| 유해성 요약 | Anthraquinones are toxic by ingestion and may cause vomiting, diarrhea, kidney and liver damage, and comaDeaths have been reported after children ingested Rhamnus berries[HSDB] Occupational asthma confirmed in workers in dye manufacturing plant[Malo] Cochineal is the dried bodies of the female insect coccus cacti. Carminic acid is the active coloring material, and carmine is the aluminum lake of carminic acid. [HSDB] See Carminic acid and Cochineal. |
| Hazard Classes and Categories | Not Classified |
| 유해 작용 | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents. |
| 수질 위해 등급(WGK) | 2 |
| TSCA 등재 상태 | TSCA listed |
| 관세 코드 | 32129000 |
| 안전 문구(S) | 22-24/25 |
| 기존화학 물질 | KE-17707 |
| 저장 분류 | 11 - Combustible Solids |
| 유해 물질 데이터 | 1260-17-9(Hazardous Substances Data) |
용도
역사
CI Natural Red 4(CI 75470), is a red dye occurring as a glycoside in the body of the cochineal insect Dactylopius coccus of the order Homoptera, family Coccidae. This insect is native to Central and South America. The Aztecs had extracted the dye from the insect centuries before the coming of the Spaniards. For breeding purposes, the insects were collected in the autumn and carefully protected during the winter months. Cochineal was harvested after three months, and then the bugs were killed by immersion in hot water, by placing in hot ovens, or by exposure to the hot sun. The latter method produced the highest quality dye. At present, Peru and the Canary Islands are the main source of the dye. Until the advent of synthetic dyes, the principal use for carminic acid was for dyeing tin-mordanted wool or silk. Its aluminum lake, carmine, finds use in the coloring of foods.
용도
Carminic acid (C.I. 75470) For staining nuclei in histological sections. Used to prepare staining solutions. CAS 1260-17-9, pH 1.6 (10g/l, HO, 20°C).
일반 설명
Dark purplish-brown mass or bright red or dark red powder. Darkens at 248°F. Deep red color in water. Yellow to violet in acidic aqueous solutions.